Spectrums of Amyotrophic Lateral Sclerosis. Группа авторов

      

      Table of Contents

      1  Cover

      2  Title Page

      3  Copyright Page

      4  Dedication Page

      5  Contributors

      6  Foreword

      7  Preface

      8  Acknowledgments

      9  CHAPTER 1: Clinical Heterogeneity of ALS – Implications for Models and Therapeutic Development INTRODUCTION CLINICAL HETEROGENEITY OF ALS PLEIOTROPY OF ALS GENES GENETIC MODELS TO STUDY ALS CONCLUSION CONFLICT OF INTEREST COPYRIGHT AND PERMISSION STATEMENT REFERENCES

      10  CHAPTER 2: Genetic Basis of ALS INTRODUCTION GENES CAUSING ALS RECENTLY DISCOVERED GENES ASPECTS OF ALS HERITABILITY NONCODING VARIATION CONCLUSIONS ACKNOWLEDGMENTS CONFLICT OF INTEREST COPYRIGHT AND PERMISSION STATEMENT REFERENCES

      11  CHAPTER 3: Susceptibility Genes and Epigenetics in Sporadic ALS INTRODUCTION ENVIRONMENTAL ASSOCIATIONS IN sALS GENETIC BASIS OF sALS IDENTIFICATION OF sALS SUSCEPTIBILITY GENES CANDIDATE sALS SUSCEPTIBILITY GENES EPIGENETIC MECHANISMS IN sALS MODIFICATIONS TO THE EPIGENOME BY ENVIRONMENTAL FACTORS CONCLUSION CONFLICT OF INTEREST COPYRIGHT AND PERMISSION STATEMENT REFERENCES

      12  CHAPTER 4: The Lessons of ALS‐PDC – Environmental Factors in ALS Etiology INTRODUCTION KOCH'S POSTULATES IN THE SEARCH OF ETIOLOGICAL ALS FACTORS NEUROLOGICAL DISEASE CLUSTERS THE NATURAL HISTORY OF ALS‐PDC INVESTIGATING ETIOLOGICAL FACTORS IDENTIFIED CYCAD TOXIN/TOXICANTS ALUMINUM AND IONIC ETIOLOGIES FOR ALS‐PDC OTHER MOLECULES THAT MIGHT HAVE BEEN INVOLVED IN ALS‐PDC A PUTATIVE VIRAL ETIOLOGY FOR ALS‐PDC ON GUAM AND ALS IN GENERAL THE CONTINUING IMPORTANCE OF ALS‐PDC SUMMARY AND CONCLUSIONS ACKNOWLEDGMENTS CONFLICT OF INTEREST COPYRIGHT AND PERMISSION STATEMENT REFERENCES

      13  CHAPTER 5: The Microbiome of ALS – Does It Start from the Gut? INTRODUCTION RECENT STUDIES HOW COULD THE MICROBIOME CONTRIBUTE TO ALS? MICROBIOME MODULATION AS A POTENTIAL THERAPEUTIC AVENUE CONCLUSION CONFLICT OF INTEREST COPYRIGHT AND PERMISSION STATEMENT REFERENCES

      14  CHAPTER 6: Protein Aggregation in Amyotrophic Lateral Sclerosis INTRODUCTION PATHOLOGICAL PROTEIN INCLUSIONS ASSOCIATED WITH ALS CONSEQUENCES OF PROTEIN AGGREGATION IN ALS THE PRIMARY AGGREGATING PROTEINS IN ALS