Caries Management - Science and Clinical Practice. Группа авторов

E, Pelliniemi L, Foidart JM. Immunohistochemical localization of types I and III collagen and fibronectin in the dentine of carious human teeth. Arch Oral Biol 1986; 31(12):801–806

      42. Zavgorodniy AV, Rohanizadeh R, Bulcock S, Swain MV. Ultra-structural observations and growth of occluding crystals in carious dentine. Acta Biomater 2008;4(5):1427–1439

      43. Fish EW. Surgical pathology of the mouth. London: Pitman and Sons; 1948

      44. Shovelton DS. The maintenance of pulp vitality. Br Dent J 1972;133(3):95–101

      45. Langeland K. Tissue response to dental caries. Endod Dent Traumatol 1987;3(4):149–171

      46. Reeves R, Stanley HR. The relationship of bacterial penetration and pulpal pathosis in carious teeth. Oral Surg Oral Med Oral Pathol 1966;22(1):59–65

      47. Hoshino E. Predominant obligate anaerobes in human carious dentin. J Dent Res 1985;64(10):1195–1198

      48. Martin FE, Nadkarni MA, Jacques NA, Hunter N. Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis. J Clin Microbiol 2002;40(5): 1698–1704

      49. Fusayama T, Okuse K, Hosoda H. Relationship between hardness, discoloration, and microbial invasion in carious dentin. J Dent Res 1966;45(4):1033–1046

      50. Ogawa K, Yamashita Y, Ichijo T, Fusayama T. The ultrastructure and hardness of the transparent layer of human carious dentin. J Dent Res 1983;62(1):7–10

      51. Buchalla W, Imfeld T, Attin T, Swain MV, Schmidlin PR. Relationship between nanohardness and mineral content of artificial carious enamel lesions. Caries Res 2008;42(3):157–163

      52. Stübel H. Die Fluoreszenz tierischer Gewebe in ultraviolettem Licht. Arch Ges Physiol 1911;142:1–14

      53. Alfano RR, Yao SS. Human teeth with and without dental caries studied by visible luminescent spectroscopy. J Dent Res 1981; 60(2):120–122

      54. Buchalla W. Comparative fluorescence spectroscopy shows differences in noncavitated enamel lesions. Caries Res 2005;39(2): 150–156

      55. Buchalla W, Lennon ÁM, Attin T. Comparative fluorescence spectroscopy of root caries lesions. Eur J Oral Sci 2004;112(6): 490–496

      56. de Josselin de Jong E, Sundström F, Westerling H, Tranaeus S, ten Bosch JJ, Angmar-Månsson B. A new method for in vivo quantification of changes in initial enamel caries with laser fluorescence. Caries Res 1995;29(1):2–7

      57. Hibst R, Paulus R. New approach on fluorescence spectroscopy for caries detection. In: Featherstone JDB, Rechman P, Fried D, eds. Lasers in Dentistry V. Proc SPIE 1999;3593:41–147

      58. Lennon ÁM. Fluorescence-aided caries excavation (FACE) compared to conventional method. Oper Dent 2003;28(4):341–345

      59. Lennon ÁM, Buchalla W, Stookey GK. A new fluorescence method to detect residual caries. Caries Res 2001;35:265 (Abstract)

      60. van der Veen MH, ten Bosch JJ. The influence of mineral loss on the auto-fluorescent behaviour of in vitro demineralised dentine. Caries Res 1996;30(1):93–99

      61. Lennon AM, Buchalla W, Brune L, Zimmermann O, Gross U, Attin T. The ability of selected oral microorganisms to emit red fluorescence. Caries Res 2006;40(1):2–5

      62. Buchalla W, Attin T, Niedmann Y, Lennon ÁM. Porphyrins are the cause of red fluorescence of carious dentin: Verified by gradient reversed-phase HPLC. Caries Res 2008;42:223 (Abstract)

      63. Lennon AM, Buchalla W, Rassner B, Becker K, Attin T. Efficiency of 4 caries excavation methods compared. Oper Dent 2006;31(5): 551–555

      64. Micheelis W, Schiffner U. Vierte Deutsche Mundgesundheitsstudie – (DMS IV): neue Ergebnisse zu oralen Erkrankungensprävalenzen, Risikogruppen und zum zahnärztlichen Vorsorgungsgrad in Deutschland 2005. Institut der Deutschen Zahnärzte (IDZ). IDZ Materialreihe Band 31. Köln: Deutscher Ärzte-Verlag; 2006

      65. Schüpbach P, Guggenheim B, Lutz F. Human root caries: histopathology of initial lesions in cementum and dentin. J Oral Pathol Med 1989;18(3):146–156

      66. Schüpbach P, Guggenheim B, Lutz F. Human root caries: histopathology of advanced lesions. Caries Res 1990;24(3):145–158

      67. Ekstrand KR, Ricketts DN, Kidd EAM. Reproducibility and accuracy of three methods for assessment of demineralization depth of the occlusal surface: an in vitro examination. Caries Res 1997;31(3):224–231

      68. Lussi A, Jaeggi T. Erosion—diagnosis and risk factors. Clin Oral Investig 2008;12(Suppl 1):S5–S13

      69. Attin T. Methods for assessment of dental erosion. Monogr Oral Sci 2006;20:152–172

      70. Addy M, Shellis RP. Interaction between attrition, abrasion and erosion in tooth wear. Monogr Oral Sci 2006;20:17–31

      71. Attin T, Knöfel S, Buchalla W, Tütüncü R. In situ evaluation of different remineralization periods to decrease brushing abrasion of demineralized enamel. Caries Res 2001;35(3):216–222

      72. Lagerweij MD, Buchalla W, Kohnke S, Becker K, Lennon AM, Attin T. Prevention of erosion and abrasion by a high fluoride concentration gel applied at high frequencies. Caries Res 2006; 40(2):148–153

      73. Wiegand A, Attin T. Influence of fluoride on the prevention of erosive lesions—a review. Oral Health Prev Dent 2003;1(4): 245–253

      74. Schlueter N, Ganss C, Hardt M, Schegietz D, Klimek J. Effect of pepsin on erosive tissue loss and the efficacy of fluoridation measures in dentine in vitro. Acta Odontol Scand 2007;65(5): 298–305

      75. van Strijp AJ, Jansen DC, DeGroot J, ten Cate JM, Everts V. Host-derived proteinases and degradation of dentine collagen in situ. Caries Res 2003;37(1):58–65

      76. Magalhães AC, Wiegand A, Rios D, Hannas A, Attin T, Buzalaf MA. Chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ. J Dent 2009;37(12):994–998

      4 Paradigm Shift in Cariology

      Sebastian Paris, Hendrik Meyer-Lueckel

       Scientific Paradigms

       How Paradigms Influence Our Clinical Approach

       The Specific Plaque Hypothesis

       The Ecological Plaque Hypothesis

       A Current Model of Caries

      The previous chapters have addressed the etiology, pathogenesis, and clinical appearance of caries. This brief chapter will discuss the effects of scientific caries models and paradigms as well as approaches to treat the disease. Furthermore, pathogenesis will be illustrated in a model that will allow us to categorize the various options for intervention in Chapter 9. This chapter addresses the following topics:

      • The influence of scientific paradigms on dentists’ approaches to treat caries

      • The specific and ecological plaque hypotheses

      • A current model of the pathogenesis of caries

      Scientific Paradigms

      Paradigms are understood to be the generally accepted scientific concepts and the worldview in a