Neonatal Haematology. Irene Roberts

      

      Table of Contents

      1  Cover

      2  Title Page

      3  Copyright Page

      4  Preface

      5  Abbreviations

      6  1 The full blood count and blood film in healthy term and preterm neonates Introduction Red blood cell production and development in the fetus and neonate Leucocytes in the fetus and newborn Platelets and megakaryocytes in the fetus and neonate Practical problems in interpreting neonatal blood counts and films References

      7  2 Red cell disorders Neonatal anaemia Neonatal polycythaemia Haematological causes of cyanosis Principles of red cell transfusion in neonates Illustrative cases Abbreviations used in the illustrative cases References

      8  3 Neonatal infection and leucocyte disorders Leucocyte abnormalities in neonatal systemic disease Neonatal neutropenia Haematological features of neonates with Down syndrome Congenital leukaemia Illustrative cases References

      9  4 Disorders of platelets and coagulation, thrombosis and blood transfusion Thrombocytopenia overview Causes of neonatal thrombocytopenia: a practical classification based on age at onset Conditions leading to clinically significant thrombocytopenia in the neonate Investigation of neonatal thrombocytopenia Management of neonatal thrombocytopenia Platelet function disorders Thrombocytosis Abnormalities of coagulation Thrombosis General principles of neonatal platelet and plasma component transfusion Illustrative cases References

      10  Index

      11  End User License Agreement

      List of Tables

      1 Chapter 1Table 1.1 Features of fetal and neonatal red cells compared with adult red ...Table 1.2 Impact of gestational age at birth on the principal blood count p...Table 1.3 Impact of postnatal age on Hb and Hct values in healthy term and ...Table 1.4 Causes of increased numbers of circulating nucleated red blood ce...

      2 Chapter 2Table 2.1 Mechanisms of fetal and neonatal anaemiaTable 2.2 Diagnostic clues to red cell aplasia in neonates with anaemiaTable 2.3 Causes of failure of red cell production in neonates with anaemia...Table 2.4 Diagnostic clues to haemolysis in neonates with anaemia and/or ja...Table 2.5 Causes of neonatal haemolytic anaemiasTable 2.6 Laboratory features of ABO and Rh haemolytic disease of the fetus...Table 2.7 Red cell membrane disorders presenting with anaemia and/or jaundi...Table 2.8 Genes mutated in autosomal recessive and autosomal dominant or sp...Table 2.9 Red cell enzymopathies presenting with neonatal anaemia and/or ja...Table 2.10 Drugs and chemicals that may precipitate haemolysis in neonates ...Table 2.11 Haemoglobinopathies presenting with anaemia and/or jaundice in t...Table 2.12 Causes of neonatal microcytic anaemiaTable 2.13 Useful diagnostic tests in neonatal anaemia due to blood lossTable 2.14 Haematological causes of hydrops fetalisTable 2.15 Causes of neonatal polycythaemiaTable 2.16 Haematological causes of cyanosisTable 2.17 Indications for red cell transfusion in the neonatal period^*

      3 Chapter 3Table 3.1 Haematological features of infection in neonatal blood filmsTable 3.2 Causes of neutrophilia in neonatesTable 3.3 Causes of lymphocytosis in neonatesTable 3.4 Causes of eosinophilia in neonatesTable 3.5 Causes of monocytosis in neonatesTable 3.6 Causes of increased blast cells in neonatal blood filmsTable 3.7 Cytological abnormalities in metabolic and storage disorders and ...Table 3.8 Causes of neonatal neutropenia^* Table 3.9 Inherited causes of severe congenital neutropenia that present in...Table 3.10 Haematological abnormalities in neonates with Down syndromeTable 3.11 Congenital leukaemias excluding those associated with Down syndr...Table 3.12 Causes of a ‘blueberry muffin’ rash in a neonate

      4 Chapter 4Table 4.1 Causes of fetal thrombocytopeniaTable 4.2 Causes of early‐onset neonatal thrombocytopenia (presenting befor...Table 4.3 Causes of late‐onset neonatal thrombocytopenia (presenting after ...Table 4.4 Inherited thrombocytopenias that may present in neonates as isola...Table 4.5 Syndromic inherited thrombocytopenias that may present in the neo...Table 4.6 Inherited thrombocytopenias associated with predisposition to leu...Table 4.7 Suggested thresholds of platelet count for neonatal platelet tran...Table 4.8 Causes of abnormal neonatal platelet