Biopharmaceutics. Группа авторов

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ADVANCES IN PHARMACEUTICAL TECHNOLOGY

       A Wiley Book Series

      Series Editors: Dennis Douroumis, University of Greenwich, UK Alfred Fahr, Friedrich–Schiller University of Jena, Germany Jurgen Siepmann, University of Lille, France Martin Snowden, University of Greenwich, UK Vladimir Torchilin, Northeastern University, USA

       Titles in the Series

      Hot‐Melt Extrusion: Pharmaceutical Applications Edited by Dionysios Douroumis

      Drug Delivery Strategies for Poorly Water‐Soluble Drugs Edited by Dionysios Douroumis and Alfred Fahr

      Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery Edited by Defang Ouyang and Sean C. Smith

      Pulmonary Drug Delivery: Advances and Challenges Edited by Ali Nokhodchi and Gary P. Martin

      Novel Delivery Systems for Transdermal and Intradermal Drug Delivery Edited by Ryan Donnelly and Raj Singh

      Drug Delivery Systems for Tuberculosis Prevention and Treatment Edited by Anthony J. Hickey

      Continuous Manufacturing of Pharmaceuticals Edited by Peter Kleinebudde, Johannes Khinast, and Jukka Rantanen

      Pharmaceutical Quality by Design Edited by Walkiria S Schlindwein and Mark Gibson

      In Vitro Drug Release Testing of Special Dosage Forms Edited by Nikoletta Fotaki and Sandra Klein

      Characterization of Pharmaceutical Nano‐ and Microsystems Edited by Leena Peltonen

      Biopharmaceutics: From Fundamentals to Industrial Practice Edited by Hannah Batchelor

      Forthcoming Titles:

      Process Analytics for Pharmaceuticals Edited by Jukka Rantanen, Clare Strachan and Thomas De Beer

      Mucosal Drug Delivery Edited by Rene Holm

Biopharmaceutics

      From Fundamentals to Industrial Practice

       Edited by

       HANNAH BATCHELOR

       Strathclyde Institute of Pharmacy and Biomedical Sciences

       University of Strathclyde Glasgow, United Kingdom

This edition first published 2022 © 2022 John Wiley & Sons Ltd

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      The right of Hannah Batchelor to be identified as the author of the editorial material in this work has been asserted in accordance with law.

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      Limit of Liability/Disclaimer of Warranty In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

       Library of Congress Cataloging‐in‐Publication Data

      Names: Batchelor, Hannah, editor.

      Title: Biopharmaceutics : from fundamentals to industrial practice / edited by Hannah Batchelor.

      Other titles: Biopharmaceutics (Batchelor) | Advances in pharmaceutical technology.

      Description: First edition. | Chichester, UK ; Hoboken, NJ : John Wiley & Sons, 2022. | Series: Advances in pharmaceutical technology | Includes bibliographical references and index.

      Identifiers: LCCN 2021050446 (print) | LCCN 2021050447 (ebook) | ISBN 9781119678281 (cloth) | ISBN 9781119678274 (adobe pdf) | ISBN 9781119678373 (epub)

      Subjects: MESH: Biopharmaceutics–methods | Drug Design

      Classification: LCC RM301.5 (print) | LCC RM301.5 (ebook) | NLM QV 35 | DDC 615.7–dc23/eng/20211101

      LC record available at https://lccn.loc.gov/2021050446 LC ebook record available at https://lccn.loc.gov/2021050447

      Cover Design: Wiley

      Cover Image: © SCIEPRO/Getty Images

List of Contributors

      Precious Akhuemokhan Institute of Pharmaceutical Sciences, King’s College London, London, United Kingdom

      Abdul W. Basit Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom

      Hannah Batchelor Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

      Shanoo Budhdeo Seda Pharmaceutical Development Services, Alderley Edge,