Selected by Choice as a 2013 Outstanding Academic Title
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
A cutting-edge survey of contemporary thought at the intersection of science and Christianity. Provides a cutting-edge survey of the central ideas at play at the intersection of science and Christianity through 54 original articles by world-leading scholars and rising stars in the discipline Focuses on Christianity's interaction with Science to offer a fine-grained analysis of issues such as multiverse theories in cosmology, convergence in evolution, Intelligent Design, natural theology, human consciousness, artificial intelligence, free will, miracles, and the Trinity, amongst many others Addresses major historical developments in the relationship between science and Christianity, including Christian patristics, the scientific revolution, the reception of Darwin, and twentieth century fundamentalism Divided into 9 Parts: Historical Episodes; Methodology; Natural Theology; Cosmology & Physics; Evolution; The Human Sciences; Christian Bioethics; Metaphysical Implications; The Mind; Theology; and Significant Figures of the 20th Century Includes diverse perspectives and broadens the conversation from the Anglocentric tradition
A must-have reference to more than 100 common residential conditions—from accessibility issues to working with zinc Practical information that the architect, engineer, contractor and homeowner can access quickly, with over 230 supporting tables photos and details Identifies frequently used reference standards, acceptable practices, and other relevant resources Quick, reliable answers to your most common on-site questions When you're in the field, you never know what you'll come across. Graphic Standards Field Guide to Residential Construction gives you fast access to the information you need when you're on-site and under pressure. Presented in a highly visual and easily portable format, Graphic Standards Field Guide to Residential Construction is organized by CSI's MasterFormat and is coordinated with the 2009 International Residential Code, as well as current sustainable practices. It addresses issues pertaining to residential construction by covering every aspect of the process, such as the use of materials, structural concerns, finishes, thermal and moisture protection, accessible design applications, and more. Graphic Standards Field Guide to Residential Construction extends beyond the studio, with: Quick access to essential information wherever you are Graphic Standards-quality details accompanied by photographs and tables Illustrations that help you troubleshoot problems, along with on-the-spot solutions Compact format that's easy to reference and carry along Graphic Standards Field Guide to Residential Construction is a handy companion that offers the essential tools that time-crunched professionals can turn to in an instant when dealing with clients, or when handling the many complex demands surrounding construction management.
This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging. • Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure • Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information • Focuses on an emerging and important area for pharmaceutical and medical applications • Encompasses technical, regulatory, and application aspects • Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control
Pick up any hydrology textbook and it will not be long before you encounter pages listing sequences of equations representing complex mathematical concepts. Students and practitioners of hydrology will not find this very helpful, as their aim, generally, is to study and understand hydrology, and not to find themselves confronted with material that even students of mathematics would find challenging. Often, equations appear to be copied and pasted into hydrological texts in an attempt to give a more rigorous scientific basis to the narrative. However, they are commonly wrong, poorly explained, without context or background, and more likely to confuse and distance the reader than to enlighten and engage them in the topic. Understanding Mathematical and Statistical Techniques in Hydrology provides full and detailed expositions of such equations and mathematical concepts, commonly used in hydrology. In contrast to other hydrological texts, instead of presenting abstract mathematical hydrology, the essential mathematics is explained with the help of real-world hydrological examples.
Suicide is the second-leading cause of death among college students. Further, one in ten college students has considered suicide in the past year. Experts have called for a comprehensive, systemic approach to campus suicide prevention that addresses both at-risk groups and the general campus population. Since 2005, 138 colleges and universities have received funding under the Garrett Lee Smith Memorial Act to develop and implement campus suicide prevention programs. This volume highlights successful strategies implemented by grantee campuses. These approaches can serve as models to address student suicide and prevention on other campuses. This is the 141st volume of this Jossey-Bass higher education quarterly series. An indispensable resource for vice presidents of student affairs, deans of students, student counselors, and other student services professionals, New Directions for Student Services offers guidelines and programs for aiding students in their total development: emotional, social, physical, and intellectual.
Achieving Cultural Competency: A Case-Based Approach to Training Health Professionals provides the necessary tools to meet the ever-growing need for culturally competent practitioners and trainees. Twenty-five self-study cases cover a variety of medical topics, including cardiovascular, pulmonary, neurology, oncology, hematology, immunology, and pediatric disorders. Actual scenarios that occurred in clinical settings help the user gain direct insight into the realities of practice today. Cultural factors covered within the cases include cultural diversity plus gender, language, folk beliefs, socioeconomic status, religion, and sexual orientation. This book is an approved CME-certifying activity to meet physicians’ cultural competency state requirements. Get 25 pre-approved self-study American Dietetic Association credits at no additional charge when you purchase the book. Email [email protected] for further instructions.
The Blackwell Companion to the Economics of Housing will help students and professionals alike to explore key elements of the housing economy: home prices, housing wealth, mortgage debt, and financial risk. Features 24 original essays, including an editorial introduction and three section overviews Includes 39 world-class authors from a mix of educational and financial organizations in the UK, Europe, Australia, and North America Broadly-based, scholarly, and accessible, serving students and professionals who wish to understand how today’s housing economy works Profiles the role and relevance of housing wealth; the mismanagement of mortgage debt; and the pitfalls and potential of hedging housing risk Key topics include: the housing price bubble and crash; the subprime mortgage crisis in the US and its aftermath; the links between housing wealth, the macroeconomy, and the welfare of home-occupiers; the mitigation of credit and housing investment risks Specific case studies help to illustrate concepts, along with new data sets and analyses to illustrate empirical points
Rendering High Dynamic Range (HDR) scenes on media with limited dynamic range began in the Renaissance whereby painters, then photographers, learned to use low-range spatial techniques to synthesize appearances, rather than to reproduce accurately the light from scenes. The Art and Science of HDR Imaging presents a unique scientific HDR approach derived from artists’ understanding of painting, emphasizing spatial information in electronic imaging. Human visual appearance and reproduction rendition of the HDR world requires spatial-image processing to overcome the veiling glare limits of optical imaging, in eyes and in cameras. Illustrated in full colour throughout, including examples of fine-art paintings, HDR photography, and multiple exposure scenes; this book uses techniques to study the HDR properties of entire scenes, and measures the range of light of scenes and the range that cameras capture. It describes how electronic image processing has been used to render HDR scenes since 1967, and examines the great variety of HDR algorithms used today. Showing how spatial processes can mimic vision, and render scenes as artists do, the book also: Gives the history of HDR from artists' spatial techniques to scientific image processing Measures and describes the limits of HDR scenes, HDR camera images, and the range of HDR appearances Offers a unique review of the entire family of Retinex image processing algorithms Describes the considerable overlap of HDR and Color Constancy: two sides of the same coin Explains the advantages of algorithms that replicate human vision in the processing of HDR scenes Provides extensive data to test algorithms and models of vision on an accompanying website www.wiley.com/go/mccannhdr