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Скачивание или чтение онлайн электронных книг.Human Drug Targets. A Compendium for Pharmaceutical Discovery
The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.
Video Art Theory. A Comparative Approach
Video Art Theory: A Comparative Approach demonstrates how video art functions on the basis of a comparative media approach, providing a crucial understanding of video as a medium in contemporary art and of the visual mediations we encounter in daily life. A critical investigation of the visual media and selected video artworks which contributes to the understanding of video as a medium in contemporary art The only study specifically devoted to theorizing the medium of video from the perspective of prominent characteristics which result from how video works deal with time, space, representation, and narrative The text has emerged out of the author’s own lectures and seminars on video art Offers a comparative approach which students find especially useful, offering new perspectives
Buddhist Philosophy. A Comparative Approach
Buddhist Philosophy: A Comparative Approach presents a series of readings that examine the prominent thinkers and texts of the Buddhist tradition in the round, introducing contemporary readers to major theories and debates at the intersection of Buddhist and Western thought. Takes a comparative, rather than oppositional, approach to Buddhist philosophy, exploring key theories and debates at the intersection of Eastern and Western thought Addresses a variety of topics that represent important points of convergence between the Buddhist and Western philosophical traditions Features contributions from a wide array of acclaimed international scholars in the discipline Provides a much-needed cross-cultural treatment of Buddhist philosophy appropriate for undergraduate students and specialists alike
Stereoelectronic Effects. A Bridge Between Structure and Reactivity
Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science
Writing for Earth Scientists. 52 Lessons in Academic Publishing
The time has come. You are an Earth scientist. You’ve spent weeks, months, years working on this project – now is the time to pull it together for publication. You might be writing an undergraduate or graduate thesis, a research paper for a leading journal, a note for the newsletter of the local amateur scientific society, a book review or an abstract for a specialist geological conference. How do you make the transition from promising unpublished researcher to established academic author? Of course, the phrase ‘academic publishing’ covers a multitude of sins; monographs, research papers, book reviews, conference abstracts or whatever each requires a different approach. You have to decide what it is you are going to write and where to publish it. There are co-authors, supervisors of your degree, peer reviewers and editors to deal with on the way. But the only way to write like an academic is to write like an academic. . . where do you start? You could do much worse than start here. There are many books on how to write and be published aimed at research students and other aspiring academics. Many of these are readable, comprehensive and provide good advice. This book is composed of numerous short chapters on this subject, all directly relevant to one or more aspects of academic publishing and aimed particularly at the Earth scientists in the broadest sense. Geologists will be encouraged to use the book as much as a reference as a reader, ‘dipping in’ to the chapters that contain relevant tips, hints and comments to enable them to improve the paper that they are currently writing. The book is intended to be informative, readable and, above all, of practical application for all readers. In summary, the volume will be a readable compilation investigating many facets of academic publishing relevant to the Earth sciences. It will be of particular interest to postgraduate students, postdocs and new academics
LTE & LTE Advanced. 4G Network Radio Interface
This book presents the technical characteristics of the two radio network interfaces of mobile 4G, LTE and LTE Advanced, based on Release 8, 9 and 10 of the 3GPP specifications. Points covered include a detailed description of various components of the radio interface. RRC signaling messages used to establish the connection, enabling the security, the paging, the establishment and the release of dedicated and default support and the handover. The PDCP ensures the security of the transmission and allows the recovery during handover and the compression of the headers. The RLC protocol defines the transmission modes with or without acknowledgment. The MAC protocol determines the random access, the data transfer, the timing advance, the scheduling and the discontinuous reception. The physical layer includes a description of the methods of multiplexing (time, frequency and space) and the various signals and physical channels.
Cable-Stayed Bridges. 40 Years of Experience Worldwide
The need for large-scale bridges is constantly growing due to the enormous infrastructure development around the world. Since the 1970s many of them have been cable-stayed bridges. In 1975 the largest span length was 404 m, in 1995 it increased to 856 m, and today it is 1104 m. Thus the economically efficient range of cable-stayed bridges is tending to move towards even larger spans, and cable-stayed bridges are increasingly the focus of interest worldwide. This book describes the fundamentals of design analysis, fabrication and construction, in which the author refers to 250 built examples to illustrate all aspects. International or national codes and technical regulations are referred to only as examples, such as bridges that were designed to German DIN, Eurocode, AASHTO, British Standards. The chapters on cables and erection are a major focus of this work as they represent the most important difference from other types of bridges. The examples were chosen from the bridges in which the author was personally involved, or where the consulting engineers, Leonhardt, Andra and Partners (LAP), participated significantly. Other bridges are included for their special structural characteristics or their record span lengths. The most important design engineers are also presented. Note: The lecture videos which are attached to the print book on DVD are not part of the e-book.
Modern Spain. 1808 to the Present
Modern Spain: 1808 to the Present is a comprehensive overview of Spanish history from the Napoleonic era to the present day. Places a large emphasis on Spain's place within broader European and global history The chronological political narrative is enriched by separate chapters on long term economic, social and cultural developments This presentation of modern Spanish history incorporates the latest thinking on key issues of modernity, social movements, nationalism, democratization and democracy
England and its Rulers. 1066 - 1307
This is an updated and expanded edition of a classic introduction to medieval England from the reign of William the Conqueror to Edward I. Includes a new chapter on family and gender roles, revisions throughout to enhance the narrative flow, and further reading sections containing the most up-to-date sources Offers engaging and clear discussion of the key political, economic, social, and cultural issues of the period, by an esteemed scholar and writer Illustrates themes with lively, pertinent examples and important primary sources Assesses the reigns of key Norman, Angevin, and Plantagenet monarchs, as well as the British dimension of English history, the creation of wealth, the rise of the aristocracy, and more
Advertising by Design. Generating and Designing Creative Ideas Across Media
A real-world introduction to advertising design in today's industry Advertising by Design is the most comprehensive, up-to-date guide to concept generation and design for advertising. Step-by-step instructions and expert discussion guide you through the fundamentals, as you develop the deeper understanding that connects the dots and sparks your creativity. Interviews with leading creative directors provide a glimpse into the real-world idea generation process, and case studies of successful ads allow you to dissect both the process and result to discover the keys to effective advertising. This new third edition has been thoroughly updated to reflect the industry's shift from print and TV ads to fully integrated transmedia campaigns, giving you invaluable insight into a broad range of media channels. New concepts and strategies for social media, digital media, pull marketing, creative content, and more are discussed in depth to help you tell an engaging story using every tool at your disposal. Ancillaries include PowerPoint slides and quizzes bring this book right into the classroom for a complete introduction to advertising design. Students seeking a career in advertising need the ability to generate idea-driven campaigns and adapt them for use in print, mobile, television, and social media formats. This book provides the well-rounded instruction required to succeed in the digital age. Master the fundamentals of advertising design for a range of media channels Integrate print, web, social media, and more to convey an engaging story Jumpstart your creativity with lessons from top creative directors Build your knowledge base around the reality of modern advertising Effective advertisers blend ideas, information, and entertainment in a way that reaches a range of audiences through a range of media types; this requires deep mastery of idea generation, copywriting, and graphic design. Advertising by Design helps you develop the skills and knowledge today's advertising industry demands.