Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураSulphur in Biology
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Carbon-Fluorine Compounds
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Isotopes in Biochemistry
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Telomeres and Telomerase
Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.
Vitamin D Handbook
A Comprehensive Reference On Vitamin D CHEMISTRY This hands-on, comprehensive reference provides accessible, organized information on the structures and applications of Vitamin D and its related chemicals. The most extensive published list of Vitamin D molecules, it provides a record for approximately 950 derivatives of Vitamins D2 and D3. Information provided of each compound includes: * Structure, chemical name, synonyms, and properties * Information on bioactivities, structure-activity relationships (SAR), synthesis, and toxicity data * CAS registry number and/or NLM PubChem chemical identification number * References to published work on the compound This unique, full perspective on the chemistry of Vitamin D includes detailed indexes that facilitate the search for a specific compound. With monographs of all the chemicals related to Vitamin D in published literature, Vitamin D Handbook: Structures, Synonyms, and Properties is an invaluable resource for anyone conducting research on Vitamin D, including chemists, biochemists, research directors, and clinical directors. It is also an excellent resource for graduate students. G. W. A. MILNE spent thirty-five years as a senior researcher at the National Institutes of Health where he worked on spectroscopy for structure determination of organic compounds and on molecular modeling in the design of drugs for the treatment of cancer and AIDS. He is a former editor of the ACS Journal of Chemical Information and Computer Sciences. In addition, he is the editor of seventeen Ashgate Handbooks, including the Ashgate Handbook of Pesticides and Agricultural Chemicals; Gardner's Chemical Synonyms and Trade Names, Eleventh Edition; Drugs: Synonyms and Properties, Second Edition; and Gardner's Commercially Important Chemicals (all published by Wiley). In 1999, he was one of two recipients of the Skolnik Award from the Chemical Information Division of the American Chemical Society. MICHAEL DELANDER is a biotechnology consultant and the founder and research librarian for MDs Research Library, a literature and Internet sources research firm.
Drug Discovery Research
Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy The progress towards the identification of susceptibility genes and phenotype-determining genes The pharmacogenetics of IBD Mucosal immunology and therapeutic strategies stemming therefrom
Percept, Decision, Action
Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored models (short-term and long-term memory), decision-making and planning of actions were treated by most neuroscientists as separate areas of research. This was not because the neuroscience community believed these operations to act independently—it is intuitive that any common cognitive process seamlessly interweaves these operations—but because too little was known about the individual processes constituting the full behaviour, and experimental paradigms and data collection methods were not sufficiently well developed to put the processes in sequence in any controlled manner. These limitations are now being overcome in the leading cognitive neuroscience laboratories, and this book is a timely summary of the current state of the art. The theme of the book is how the brain uses sensory information to develop and decide upon the appropriate action, and how the brain determines the appropriate action to optimize the collection of new sensory information. It addresses several key questions. How are percepts built up in the cortex and how are judgments of the percept made? In what way does information flow within and between cortical regions, and what is accomplished by successive (and reverberating) stages of processing? How are decisions made about the percept subsequently acted upon, through their conversion to a response according to the learned criterion for action? How does the predicted or expected sensation interact with the actual incoming flow of sensory signals? The chapters and discussions in the book reveal how answering these questions requires an understanding of sensory–motor loops: our perception of the world drives new actions, and the actions undertaken at any moment lead to a new ‘view’ of the world. This book is a fascinating read for all clinical and experimental psychologists and neuroscientists, as well as anyone interested in how we perceive the world and act within it.
Funding Ranking 2006
Deutsche Forschungsgemeinschaft (DFG)
Following on from previous publications in 1997, 2000 and 2003, the Deutsche Forschungsgemeinschaft (German Research Foundation) presents its fourth «Funding Ranking», an overview of the distribution of awards to universities and non-university research institutions in Germany. The scope of the report has increased considerably compared to previous editions. Alongside the report's central indicator – DFG awards per individual research institution – the document also covers a wide range of additional indicators regarding publicly financed research in one of the world's leading industrial countries. For the first time, the report also includes information on R&D funding for selected federal programmes, for thematic priorities within the European Union's Sixth Framework Programme, and for collaborative industrial research funded by the German Federation of Industrial Cooperative Research Associations «Otto von Guericke». The third party funding indicators, which each depict individual aspects of publicly financed research, represent in total approximately 80 percent of all public third party funding for university research.
Advances in Chemical Physics
Providing the chemical physics field with a forum for critical, authoritative evaluations in every area of the discipline, the latest volume of Advances in Chemical Physics continues to provide significant, up-to-date chapters written by internationally recognized researchers. This volume is essentially devoted to helping the reader obtain general information about a wide variety of topics in chemical physics. Advances in Chemical Physics, Volume 117 includes chapters addressing laser photoelectron spectroscopy, nonadiabatic transitions due to curve crossings, multidimensional raman spectroscopy, birefringence and dielectric relaxation in strong electric fields, and crossover formulae for Kramers Theory of thermally activated escape rates.