With its focus on industrial pharmaceutical research, written by international experts from the industry, this book fills in a gap in the existing literature. It reflects the combination of such pharmaceutical interests as drug delivery, drug targeting, quality and safety management, drug approval and regulation, patenting issues and biotechnology fundamentals. Thus it provides practitioners in pharmaceutical biotechnology with all the relevant information from the shelf. The first part offers a comprehensive survey and review of the rapidly increasing array of biopharmaceuticals derived from the molecular biological approaches now widely available. This is followed by an extra section devoted to the very critical patenting and drug regulation issues. The whole is rounded off by detailed monographs of biotechnologically developed drugs that are already on the market. With a foreword of by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at the Massachusetts Institute of Technology. In 2002, he received the Charles Stark Draper Prize, the highest recognition for an engineer. Professor Langer is member of all three national academies – the Institute of Medicine, the National Academy of Engineering, and the National Academy of Sciences: «The book attempts to provide a balanced view of the biotechnological industry and the number of experts from industry sharing their knowledge and experience with the audience gives the book an outstanding value. All contributors provide with each chapter an up-to-date review on key topics in pharmaceutical biotechnology. This work is not only a valuable tool for the industrial expert but also for all pharmacists and scientists from related areas who wish to work with biotech drugs.»
Comprehensive in its scope and illustrated in detail, this practical book provides a fundamental insight into the complex world of tissue development and artificial cell culture using tissue engineering. The introductory chapters cover basic cell biology and cellular development as well as cell culture, with a main emphasis on ways of differentiating tissue and the critical evaluation of the properties of maturing tissue constructs. The authors also focus on the use of stem cells from the most varied sources in tissue engineering. The whole is rounded off by an exceptionally wide-ranging glossary containing some 1,000 key words from the fields of cell biology, cell culture development and tissue engineering.
A deeper insight into the complex processes involved in this field, covering the biological, chemical and engineering fundamentals needed to further develop effective methodologies. The book devotes detailed chapters to each of the four main areas of environmental biotechnology – wastewater treatment, soil treatment, solid waste treatment, and waste gas treatment – dealing with both the microbiological and process engineering aspects. The result is the combined knowledge contained in the extremely successful volumes 11a through 11c of the «Biotechnology» series in a handy and compact form.
A unique resource for the next generation of biotech innovators Enabling everything from the deciphering of the human genome to environmentally friendly biofuels to lifesaving new pharmaceuticals, biotechnology has blossomed as an area of discovery and opportunity. Modern Biotechnology provides a much-needed introduction connecting the latest innovations in this area to key engineering fundamentals. With an unmatched level of coverage, this unique resource prepares a wide range of readers for the practical application of biotechnology in biopharmaceuticals, biofuels, and other bioproducts. Organized into fourteen sections, reflecting a typical semester course, Modern Biotechnology covers such key topics as: Metabolic engineering Enzymes and enzyme kinetics Biocatalysts and other new bioproducts Cell fusion Genetic engineering, DNA, RNA, and genes Genomes and genomics Production of biopharmaceuticals Fermentation modeling and process analysis Taking a practical, applications-based approach, the text presents discussions of important fundamentals in biology, biochemistry, and engineering with relevant case studies showing technology applications and manufacturing scale-up. Written for today's wider, more interdisciplinary readership, Modern Biotechnology offers a solid intellectual foundation for students and professionals entering the modern biotechnology industry.
A must-read for anyone working in electronics in the healthcare sector This one-of-a-kind book addresses state-of-the-art integrated circuit design in the context of medical imaging of the human body. It explores new opportunities in ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine (PET, SPECT), emerging detector technologies, circuit design techniques, new materials, and innovative system approaches. Divided into four clear parts and with contributions from a panel of international experts, Medical Imaging systematically covers: X-ray imaging and computed tomography–X-ray and CT imaging principles; Active Matrix Flat Panel Imagers (AMFPI) for diagnostic medical imaging applications; photon counting and integrating readout circuits; noise coupling in digital X-ray imaging Nuclear medicine–SPECT and PET imaging principles; low-noise electronics for radiation sensors Ultrasound imaging–Electronics for diagnostic ultrasonic imaging Magnetic resonance imaging–Magnetic resonance imaging principles; MRI technology
Correlative Learning: A Basis for Brain and Adaptive Systems provides a bridge between three disciplines: computational neuroscience, neural networks, and signal processing. First, the authors lay down the preliminary neuroscience background for engineers. The book also presents an overview of the role of correlation in the human brain as well as in the adaptive signal processing world; unifies many well-established synaptic adaptations (learning) rules within the correlation-based learning framework, focusing on a particular correlative learning paradigm, ALOPEX; and presents case studies that illustrate how to use different computational tools and ALOPEX to help readers understand certain brain functions or fit specific engineering applications.
A unique, comprehensive reference that integrates the molecular, cellular, physiological, pathological, and engineering aspects of regenerative processes Bioregenerative engineering is an emerging discipline based on applying engineering principles and technologies to regenerative medicine. It induces, modulates, enhances, and/or controls regenerative processes by using engineering approaches to improve the restoration of the structure and function of disordered or lost molecules, cells, tissues, and organs. This reference systematically summarizes bioregenerative engineering principles, technologies, and current research to help scientists understand biological regeneration and design new therapeutic strategies. Succinct and well-organized with a detailed table of contents to help readers pinpoint information, this reference: * Provides the fundamental theory and principles of molecular, cellular, and tissue regenerative engineering concurrently with experimental approaches * Presents the foundations of bioregenerative engineering, encompassing the molecular basis, the regulatory mechanism of regeneration, and the developmental aspects * Combines molecular and cell biology with potential applications * Addresses experimental design, methods, and modeling at the molecular/cellular/tissue levels * Covers the general mechanisms and technologies of bioregenerative engineering, as well as its application to the treatment of human disorders * Discusses the engineering tests and therapies for major organ systems Presenting an in-depth introduction to the biological and engineering aspects of the field and an up-to-date overview of current research, this is a one-of-a-kind resource for scientific researchers and medical practitioners, as well as for graduate and undergraduate students in biomedical engineering, bioengineering, chemical engineering, molecular biology, and cell biology.
Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.
This new, expanded and updated edition of the user-friendly and comprehensive treatise on enzyme kinetics expertly balances theory and practice. This is an indispensable aid for advanced students and professionals working with enzymes, whether biochemists, biotechnologists, chemical biologists, pharmacologists or bioengineers in academia, industry and clinical research.
Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.