Медицина
Различные книги в жанре МедицинаCulture of Death
When his teenage son Christopher, brain-damaged in an auto accident, developed a 105-degree fever following weeks of unconsciousness, John Campbell asked the attending physician for help. The doctor refused. Why bother? The boy’s life was effectively over. Campbell refused to accept this verdict. He demanded treatment and threatened legal action. The doctor finally relented. With treatment, Christopher’s temperature—which had eventually reached 107.6 degrees—subsided almost immediately. Soon afterward the boy regained consciousness and was learning to walk again.This story is one of many Wesley J. Smith recounts in his award-winning classic critique of the modern bioethics movement, Culture of Death. In this newly updated edition, Smith chronicles how the threats to the equality of human life have accelerated in recent years, from the proliferation of euthanasia and the Brittany Maynard assisted suicide firestorm, to the potential for “death panels” posed by Obamacare and the explosive Terri Schiavo controversy.Culture of Death reveals how more and more doctors have withdrawn from the Hippocratic Oath and how “bioethicists” influence policy by posing questions such as whether organs may be harvested from the terminally ill and disabled. This is a passionate yet coolly reasoned book about the current crisis in medical ethics by an author who has made “the new thanatology” his consuming interest.
Recent Advances in Innovative Magnetic Nanomaterials for Cancer Theranostics
In this book, cancer theranostics applications of magnetic iron oxide nanoparticles are overviewed in details. Moreover, their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity have been briefly highlighted. Finally, we have mentioned the current examples of clinical trials of magnetic nanoparticles in cancer theranostics along with their future scopes and challenges.
Cobert's Manual Of Drug Safety And Pharmacovigilance (Third Edition)
Completely revised and updated, Cobert's Manual of Drug Safety and Pharmacovigilance, Third Edition , is a how-to manual for those working in the fields of drug safety, clinical research, pharmacology, regulatory affairs, risk management, quality/compliance, and in government and legal professions. This comprehensive and practical guide discusses the theory and the practicalities of drug safety (also known as pharmacovigilance), and provides essential information on drug safety and regulations in the United States, Europe Union, and more, including: recognizing, monitoring, reporting, and cataloging serious adverse drug reactions. Cobert's Manual of Drug Safety and Pharmacovigilance , Third Edition, teaches the daily practice of drug safety in industry, hospitals, the FDA and other health agencies — both in the United States and around the world — and provides critical information about what to do when confronted with a drug safety problem. Contents: The Theory and Definitions of Drug Safety — PharmacovigilanceClinical Trials, Clinical Research Organizations, Phases I–IV, and Investigator-Initiated TrialsSpontaneous Post-marketing Adverse EventsThe Theory of Drug Safety — PharmacovigilanceThe Mathematics of Adverse Events and a Brief Note on PharmacoepidemiologyEpidemiology and Pharmacoepidemiology: What Are They? What Are Their Limitations and Advantages?Regulations, Directives, Guidance, Laws and Consensus DocumentsThe United States Food and Drug AdministrationThe European Medicines AgencyThe EU Qualified Person for PharmacovigilanceThe Uppsala Monitoring CentreCouncil for International Organizations of Medical SciencesWhere Data ResideInformation Technology, Databases, and ComputersAdverse Events with New Chemical Entities, Generics, Excipients, Placebos, and CounterfeitsChildren, Elderly, and Other Special (Vulnerable) GroupsPregnancy and LactationAcute and Chronic (Late Occurring) Adverse Events, Adverse Events That Disappear (Bendectin) and DiethylstilbesterolDrug InteractionsProduct Quality IssuesAE Volume, Quality, Good Documentation Procedures, and Medical RecordsSeriousness, Expectedness, and CausalityCoding of Adverse Events and Drug NamesExpedited and Aggregate Reporting in Clinical TrialsPost-marketing Spontaneous ICSR/SAE ReportingPeriodic Adverse Drug Experience Reports, and Periodic Safety Update Reports/Periodic Benefit Risk Evaluation ReportsSignals and Signaling in the Context of Risk ManagementRisk: What Is It? Risk Management and Assessment, Risk Evaluation and Mitigation Strategies, and Risk Management PlansData Monitoring Committees and Investigational Review Boards/Ethics CommitteesPharmaceutical CompaniesOrganization of a Typical Drug Safety DepartmentHow an Individual Case Safety Report (ICSR) is Handled from Start to FinishPV Quality SystemTrainingAudits and InspectionsPharmacovigilance System Master FileEthical Issues and Conflicts of InterestThe Safety Department's Role in Clinical Research, CROs, Marketing and Sales, Labeling, Regulatory, Quality, Due Diligence, Legal Issues, Toxicology, Epidemiology, Medical Information and ManufacturingDrug LabelingUniversities and Academic Medical CentersVaccinovigilanceBusiness Partners and Exchange of Safety DataData Privacy and SecurityThe Roles and Interactions of Companies, Governments, Non-governmental Organizations, and Others in the World of PharmacovigilanceReal-World Issues: Case StudiesMedical Marijuana and PharmacovigilanceInternational Council for Harmonisation (ICH) Readership: Students, Medical professionals and others working in the field of pharmaceuticals. Physicians, nurses, pharmacists, PharmDs, PhDs, podiatrists, dentists, clinical researchers. In particular those who are involved in the safety and efficacy of drugs both in research and already on the market.Drugs;Side Effects;Adverse Reactions;Adverse Drug Reactions;Adverse Drug Effects;Adverse Drug Experiences;Toxicity;Drug Toxicity;Drug Safety;Safety00
Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies
Replicating and Repairing the Genome provides a concise overview of the fields of DNA replication and repair. The book is particularly appropriate for graduate students and advanced undergraduates, and scientists entering the field or working in related fields. The breadth of information regarding DNA replication and repair is vast and often difficult to absorb, with terminology that differs between experimental systems and with complex interconnections of these processes with other cellular pathways. This book provides simple conceptual descriptions of replication and repair pathways using mostly generic protein names, laying out the logic for how the pathways function and highlighting fascinating aspects of the underlying biochemical mechanisms and biology. The book incorporates extensive and informative diagrams and figures, as well as descriptions of a number of carefully chosen experiments that had major influences in the field. The process of DNA replication is explained progressively by starting with the system of a simple bacterial virus that uses only a few proteins, followed by the well-understood bacterial ( E coli ) system, and then culminating with the more complex eukaryotic systems. In the second half of the book, individual chapters cover key areas of DNA repair — postreplication repair of mismatches and incorporated ribonucleotides, direct damage reversal, excision repair, and DNA break repair, as well as the related areas of DNA damage tolerance (including translesion DNA polymerases) and DNA damage responses. The book closes with chapters that describe the huge impact of DNA replication and repair on aspects of human health and on modern biotechnology. Contents: The Challenges of Maintaining and Duplicating the GenomeThe Simple DNA Replication System of a Bacterial VirusThe Highly Efficient Replication System of BacteriaEukaryotic DNA ReplicationReplication Dynamics — Initiating, Regulating and Terminating Cellular DNA ReplicationPostreplication Repair of Mismatches and RibonucleotidesDNA Topology and the Enzymes That Alter ItDNA Damage — A Persistent Threat to the GenomeDirect Reversal of DNA DamageExcision Repair — Taking Advantage of the Complementary StrandRepair of Double-Strand BreaksDNA Damage Tolerance and Translesion DNA PolymerasesDNA Damage Response PathwaysDNA Replication and Repair in Human DiseaseEnzymes of DNA Replication and Repair Fuel Modern Genomic Technologies Readership: Graduate students, advanced undergraduates and scientists in the field of oncology/cancer biology.Replication;DNA Repair;Recombination;DNA;Biotechnology;Basic Research;DNA Damage;DNA Polymerase;DNA Helicase;Topoisomerase0 Key Features: As described above, the book provides a broad overview of the fields of DNA replication and repair without diving deeply into the many complexities of mechanism and terminology that are common in review articles and other books in these areas. The book carefully builds up a sophisticated understanding of the detailed mechanisms in replication and repair by introducing simple systems first, and adding layers of complexity without resorting to excessive technical jargon. Throughout the book, mechanisms and principles are illustrated with informative Figures and TablesThe process of discovery in science and the construction of informative and rigorous experiments are, for many, the most compelling aspects of being a scientist. In this book, experimental approaches are integrated into the text at times, and also augmented with side boxes that illustrate particularly interesting and/or historically important experiments. These side boxes are called «How was that tested?», and a subset illustrate the progression of scientific methodology with a «Then and Now» theme. Side boxes also highlight experimental findings that resulted in Nobel Prizes. These various side boxes are very useful when the book is adopted for a course — the course work can expand on the side box by discussing more of the experiments in that particular study, they can be used as an introduction to modern technologies in genetics, biochemistry and cell biology, and they can be used as jumping-off points for student presentations (oral or written) or for group discussionsThe author is an accomplished scientist/educator who has published over 100 research articles in the fields of DNA replication and repair, funded by extensive research grants from the NIH and other agencies. Dr Kreuzer is a Fellow of the American Academy of Microbiology and the American Association for the Advancement of Science. He has mentored high school, college, graduate and post-graduate students, and has taken a very active role in recruiting and mentoring students from underrepresented groups. Most relevant to this book, Dr Kreuzer has taught the principles of DNA replication and repair to undergraduate, graduate and medical students during his 30-year career at Duke University. In honor of his teaching and mentoring, he won the first Duke University Faculty Award for Graduate Teaching in the Basic Biomedical Sciences (2001)
Is it possible to overcome aging? Today and tomorrow cell therapy
Humanity’s dream of eternal life can come true. Russia has developed the world’s first “General Theory of Rejuvenation of Organisms”. This discovery is akin to the flight into space of the first satellite of the Earth and the first cosmonaut Yuri Gagarin. You will be one of the first to have this knowledge when you read this book by the author – Dr. in Biology, gerontologist, a specialist in cell technology. The book provides evidences justification of the human desire to live long.