Медицина
Различные книги в жанре МедицинаTargets and Emerging Therapies for Schizophrenia
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Label-Free Technologies For Drug Discovery
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Hematology Techniques and Concepts for Veterinary Technicians
Now in full color, Hematology Techniques and Concepts for Veterinary Technicians, Second Edition is a thorough update to this introduction to the fundamental concepts of collecting, handling, and preparing hematology samples. Covering the basics of blood composition, cell morphology, and sample collection, handling, and preparation, the book is designed specifically for veterinary technicians and students to gain a full understanding of why each test is performed and ensure accurate test results. In addition to addressing advances in technology, equipment, and test techniques throughout, a new chapter covers automated testing, and a companion website provides review questions and images from the book for download at www.wiley.com/go/voigt. Key concepts have also been added to each chapter to better promote learning, and terms are now defined throughout the text, with the definitions collected into a glossary. User-friendly and well-illustrated with charts, reference values, algorithms and photomicrographs, Hematology Techniques and Concepts for Veterinary Technicians, Second Edition is a key reference for veterinary technicians and veterinary technology students.
Cultural Competence in Health Education and Health Promotion
Cultural Competence in Health Education and Health Promotion, 2nd edition, examines the importance of ethnic and cultural factors for community health practice. Edited and written by a stellar list of contributors who are experts in field, this book describes essential theories, models, and practices for working with race, ethnicity, gender, and social issues. The authors cover a wide range of topics including demographics, disparities, complementary and alternative medicine, spiritually grounded approaches, multicultural populations, culturally competent needs assessment and planning, communication, workforce, program planning, aging, sexual orientation, and future challenges. This edition has substantially expanded coverage on working with diverse groups, social determinants of health, spirituality, theoretical models for multicultural populations, planning and program evaluation, and aging, with new content includes coverage of disability and health literacy. This edition also reflects the latest standards for Certified Health Education Specialist certification and national standards on Culturally and Linguistically Appropriate Services (CLAS), from Department of Health and Human Services, Office of Minority Health
Clinical Cases in Avian and Exotic Animal Hematology and Cytology
Clinical Cases in Avian and Exotic Animal Hematology and Cytology demonstrates how to use hemic cytology and cytodiagnosis as part of the assessment of an exotic animal patient, taking the reader through nearly 100 actual clinical cases. With a focus on cytological interpretation, the hands-on, practical approach facilitates learning, teaching, and comprehension. Well illustrated throughout, Clinical Cases in Avian and Exotic Animal Hematology and Cytology is a helpful guide for exotics veterinarians, zoo and aquarium veterinarians, and veterinary hematologists.
Fungal Infection. Diagnosis and Management
Fungal Infection: Diagnosis and Management, 4th Edition is a concise and up-to-date guide to the clinical manifestations, laboratory diagnosis and management of superficial, subcutaneous and systemic fungal infections. This highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by Pneumocystis jirovecii has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections. Clinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections.
Environmental Health Law. An Introduction
This important resource offers a comprehensive overview of the major U.S. environmental laws and approaches, strategies, standards, and enforcement techniques by which American law protects our environment and our health. Written for the non-lawyer, the book puts the spotlight on general concepts that go a long way to demystify the American legal system (what law consists of, who makes it, how it is made, and how it is enforced). The authors also introduce the major environmental laws and evaluate issues, controversies and developments in environmental policy.
Complications in Cardiothoracic Surgery. Avoidance and Treatment
Written to supplement standard textbooks and operative atlases, this updated reference concentrates on the issue of complication prevention and treatment. By challenging the contributors to address specific issues related to both intraoperative techniques and post-operative care that will reduce the incidence of complications, Drs. Little and Merrill present a book that reinforces the commitment to excellence in cardiothoracic surgery. The book opens with a section on general topics with regard to cardiothoracic surgical complications, including thoracic incisions, postoperative arrhythmias, and myocardial preservation. Then Drs. Little and Merrill draw on their expertise in thoracic and cardiac surgery, respectively. They have assembled a team of experts to address specific diseases encountered and operations performed by cardiac and general thoracic surgeons. With advice developed through years of experience by some of the most respected names in the field, Complications in Cardiothoracic Surgery: Avoidance and Treatment, 2nd Edition makes an ideal introduction for the new trainee and the perfect refresher for the practicing surgeon.
Getting that Medical Job. Secrets for Success
Confused and stressed by the latest round of Foundation Programme recruitment? Looking to bag that Specialty Training position? Applying for your first consultant’s post? This fully updated short guide covers recruitment at each step of the medical career, and helps you plan an effective strategy to get the job you want. The authors advise on the basics from choosing your ideal specialty, preparing a strong CV, and what to do to get shortlisted, through the application process, and the interview itself. New features include: Chapters tackling online application for the Foundation Programme, and the new structured interview in Specialty Training recruitment How to deal with the academic interview Advice on how to explain time out from training Real examples of successful and unsuccessful answers to interview questions Step-by-step key points to consider when working on your own application With advice on successfully moving and settling into your new medical job, this is the ideal aid for medical students applying for Foundation Programme training, recently qualified junior doctors applying for Specialty Training, and those applying for their first consultant post.
Hemovigilance. An Effective Tool for Improving Transfusion Safety
* Hemovigilance is a «quality process» which aims to improve quality and increase safety of blood transfusion, by surveying all activities of the blood transfusion chain, from donors to recipients. Hemovigilance programmes have now been in existence for over 15 years, but many countries and centers are still at the development stage. This valuable resource brings together the main elements of such programmes and shows the different types of models available. A general introduction includes Chapters on hemovigilance as a quality tool for transfusion as well as concepts of and models for hemovigilance. The core of the book describes how Hemovigilance systems have been set up and how they work in hospitals, blood establishments, and at a national level. These Chapters are written according to a structured template: products and processes, documentation of jobs, monitoring and assessment, implementation and evaluation of measures for improvement, education and training. Chapters on Hemovigilance at the International level, Achievements and new developments complete the picture. Hemovigilance is above all a practical guide to setting up and improving hemovigilance systems, whilst raising awareness for reporting adverse events and reactions. This is the first international book on hemovigilance, assembling all the vital issues in one definitive reference source – essential reading for all staff involved in the transfusion process.