Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.
A complete guide to understanding cluster randomised trials Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials. The book contains clear technical descriptions of the models used, and considers in detail the ethics involved in such trials and the problems in planning them. For readers and students who do not intend to run a trial but wish to be a critical reader of the literature, there are sections on the CONSORT statement, and exercises in reading published trials. Written in a clear, accessible style Features real examples taken from the authors’ extensive practitioner experience of designing and analysing clinical trials Demonstrates the use of R, Stata and SPSS for statistical analysis Includes computer code so the reader can replicate all the analyses Discusses neglected areas such as ethics and practical issues in running cluster randomised trials How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research provides an excellent reference tool and can be read with profit by statisticians, health services researchers, systematic reviewers and critical readers of cluster randomised trials.
A definitive manual covering everything you need to know about the core procedures in dentistry The Manual of Clinical Procedures in Dentistry comprehensively explains the core procedures in dentistry, how to do them, and the rationale that underpins them. Full of useful and easy-to-access information, it acts as a compendium of practical procedures in primary dental care, supporting students and dental practitioners in their daily professional and academic lives. This manual is a complete, practical guide to the delivery of effective, state of the art oral healthcare—the ‘what, when, and how’ of clinical practice. It compiles chapters written by expert clinicians on topics such as dental imaging, the management of dental pain, conscious sedation, operative dentistry, implant dentistry, oral medicine and surgery, paediatric dentistry, periodontics, prosthodontics, special care dentistry, dental trauma, aesthetic dentistry, and much more. Provides step-by-step guidance on procedures in primary dental care Comprehensive coverage of all dental disciplines, from endodontics to orthodontics Compiled by two highly experienced editors with contributions from expert authors Covers essential non-clinical areas, such as communicating with patients, obtaining valid consent, audit procedures, and handling of complaints The Manual of Clinical Procedures in Dentistry is an invaluable text for dental students and new graduates, as well as a definitive guide for the whole dental team.
Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease offers hepatologists practical, up-to-date and expert guidance on the most topical dilemmas, difficulties and areas of controversy/difficulty surrounding this ever-increasing area of liver disease they face in daily practice. Roger Williams and Simon Taylor-Robinson, two of Europe’s leading hepatologists, have recruited leading figures from across the world to assist them, resulting in a truly international approach. Each chapter covers a specific area of difficulty, containing clear learning points and providing evidence-based expert guidance on the latest hot topics in clinical management such as: Is NAFLD different in absence of Metabolic Syndrome? Are the pros outweighed by the cons of obtaining a liver biopsy? Is progression to cirrhosis more likely in children with NAFLD? What are the dangers as well as the true benefits of bariatric surgery? How is it best to use antifibrotic agents in clinical practice? Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease provides the answers to the questions and challenges that clinicians face every day in this area. It is essential reading for hepatologists of all levels and researchers in hepatology, as well as all those involved in the care of patients with NAFLD, including gastroenterologists, pathologists and specialist hepatology nurses.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
How to Succeed on Primary Care and Community Placements offers practical advice on how to get the most from your time on community visits, within patient consultations, and with the practice team. It highlights the unique opportunities and challenges you will face on placement, from using clinical information systems, to home visits and long term patient relationships, and how to take advantage of new ways of learning with web-based tools, mobile devices and social networking. Key features include: • Learning outcomes at the start of each chapter with links to web-based learning, case examples, and tasks to undertake whilst on placement • An evidence-based, practical approach to improving learning, teaching, assessment and feedback in community settings Written by a team of experienced community-based medical education specialists, it is ideal for all medical students, whether on early clinical placements or later in training, and for tutors and preceptors looking for novel ways to engage their students.
Mentoring in Nursing and Healthcare: Supporting career and personal development is an innovative look into mentoring within nursing, and its implications for career success. It provides an up-to-date review of the current research and literature within mentoring in nursing and healthcare, drawing together the distinctive challenges facing nurses and their career development. It proposes new directions and practical ways forward for the future development of formal mentoring programmes in nursing. Offering fresh insight into mentoring principles and how these can be used beyond pre-registration nurse education to support personal career development. This is an essential book for all those commencing, continuing or returning to a nursing career. Key features: Addresses mentoring as a career development tool Focuses on the individual benefits of being a mentee and mentor and how this can aid professional development Both theoretical and practical material is presented Features case studies throughout book Supports nurses to develop their careers It is sector specific but has transferability across disciplines A summary chapter draws together common threads or theoretical perspectives. The book concludes with strategies for future research and progress
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present «best practice» methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Life-Threatening Cardiac Emergencies for the Small Animal Practitioner offers a quick reference to recognizing and treating common cardiac arrhythmias and emergent cardiac conditions in canine and feline patients, designed for fast access during an emergency. Offers quick and easy access to key information for diagnosing and managing arrhythmias and cardiac conditions in dogs and cats Designed for ease of use in the fast-paced emergency setting Presents clear, reproducible ECGs, radiographs, and echocardiograms for reference and comparison Part of the Rapid Reference series providing small animal practitioners with ideal quick references for patient-side guidance
Now in its third edition, and for the first time in full-color, Exotic Animal Medicine for the Veterinary Technician is a comprehensive yet clear introduction to exotic animal practice for technicians in the classroom and clinic setting alike. With an emphasis on the exotic species most likely to present to a veterinary practice, coverage includes avian, reptiles, amphibians, fish, small mammals, and wildlife. Now in full color Features anatomy, restraint, common diseases to radiology, surgical assisting, and parasitology New chapter on fish medicine Companion website offering review questions and images from the text in PowerPoint