Epilepsy in childhood presents a profound challenge Epilepsy is an unsettling, complex condition. There is no ‘one size fits all’ option. For effective treatment a full understanding of each patient’s situation and clinical history is needed. Recent remarkable improvements in our ability to image brain structures, to define physiological patterns and in treatment options has made the task of care of the child with epilepsy potentially more effective. Epilepsy in Children and Adolescents provides the contemporary, caring guidance you need to diagnose and manage seizures in a young patient. Beginning with an overview of the classification of epilepsy syndromes, the experienced authors cover: Diagnostic evaluation of childhood epilepsies Principles of treatment Generalized seizures and generalized epilepsy syndromes Partial onset seizures and localization-related epilepsy syndromes Epilepsies relative to age, etiology or duration The full range of treatment options: medical, dietary, surgical Epilepsy in Children and Adolescents takes a practical approach to a common but complex clinical challenge.
This latest addition to the successful Network Biology series presents current methods for determining the entropy of networks, making it the first to cover the recently established Quantitative Graph Theory. An excellent international team of editors and contributors provides an up-to-date outlook for the field, covering a broad range of graph entropy-related concepts and methods. The topics range from analyzing mathematical properties of methods right up to applying them in real-life areas. Filling a gap in the contemporary literature this is an invaluable reference for a number of disciplines, including mathematicians, computer scientists, computational biologists, and structural chemists.
Expert guidance from internationally recognized authorities, who provide clear and current updates on all aspects of interventional cardiology. This new edition; Contains a radically expanded chapter contents list presented in four clear sections; coronary interventions, interventional pharmacology, structural heart interventions, and endovascular therapy Includes 46 new chapters, including the latest advances in bioresorbable coronary stents, advanced transcatheter aortic valve replacement, MitraClip, new transcatheter mitral valve interventions, and more Chapters are templated for rapid referral, beginning with pathophysiological background and relevant pathology, moving to mechanisms of treatment, device description, procedural techniques, follow-up care, and ending with risks, contraindications and complications Multiple choice questions at the end of each chapter for self-assessment, a total of more than 400 MCQs in the book Features 19 procedural videos, hosted on a companion website
Qualitative Methods in Public Health: A Field Guide for Applied Research, 2nd Edition provides a practical orientation to conducting effective qualitative research in the public health sphere. With thorough examination and simple explanations, this book guides you through the logic and workflow of qualitative approaches, with step-by-step guidance on every phase of the research. Students learn how to identify and make use of theoretical frameworks to guide your study, design the study to answer specific questions, and achieve their research goals. Data collection, analysis, and interpretation are given close attention as the backbone of a successful study, and expert insight on reporting and dissemination helps you get your work noticed. This second edition features new examples from global health, including case studies specifically illustrating study design, web and mobile technologies, mixed methods, and new innovations in information dissemination. Pedagogical tools have been added to help enhance your understanding of research design and implementation, and extensive appendices show you how these concepts work in practice. Qualitative research is a powerful tool for public health, but it's very easy to get it wrong. Careful study design and data management are critical, and it's important to resist drawing conclusions that the data cannot support. This book shows you how to conduct high-quality qualitative research that stands up to review.
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Updated to reflect the latest developments in the field, Concise Review of Veterinary Microbiology, 2nd Edition, presents essential information on veterinary microbiology for students and those requiring a refresher on key topics relating to microbial diseases in animals. Morphological, cultural and other descriptive features of pathogenic microorganisms are described, together with their habitats and aetiological roles in disease production in animals and, where appropriate, in the human population. Key features: • There are five sections covering bacteriology, mycology, virology, biosecurity and other aspects of infectious diseases • Provides concise, yet comprehensive information on pathogenic microorganisms of importance in veterinary medicine, the diseases which they cause, their diagnosis and control • The 79 short chapters in this book include 13 new chapters on antibacterial resistance, structure and function of the immune system, antifungal chemotherapy, antiviral chemotherapy, principles of biosecurity and a number of topics related to the control and prevention of infectious diseases • This latest edition uses updated nomenclature and includes detailed diagrams now in full colour, and comprehensive tables
Clinical Radiology of the Horse is the best-selling, practical guide to all areas of equine radiography and radiology written by an experienced group of clinicians with a broad range of backgrounds. Offers an atlas of normal and clinical images, as well as a comprehensive guide to techniques, equipment, positioning, and interpretation for general veterinary practitioners and specialists in imaging and orthopaedics Updates to this fourth edition fully reflect the move to digital imaging with many new figures in the book and major revisions to the chapters on the head, thorax, and abdomen Contains expanded coverage of the foot, pastern, and fetlock (now in separate chapters) Includes a password-protected website with all the images from the book as well as over 200 additional images with examples of more subtle lesions, more fractures, correct technique and positioning versus incorrect, immature horses, progression of disease, and pathological images
Clinical Radiology of the Horse is the only book dedicated to the horse which provides a comprehensive overview of radiography and radiology of all areas of the horse. It provides a thorough guide both to the techniques used to obtain radiographs of the horse and to radiographic interpretation. With almost 600 superb annotated radiographs and more than 120 line diagrams, the book combines the best features of a high quality atlas and those of a detailed reference book. The normal radiographic anatomy of immature and mature horses is presented with normal variations, incidental findings and details of significant abnormalities. Remarks on clinical prognosis and treatment are also included. The emphasis throughout is on practical tips, common pitfalls, and the techniques used to obtain the best radiographs of specific areas and conditions. Changes for the third edition: Significantly enlarged to include a chapter on digital radiography Includes descriptions of several new radiographic projections Many of the images have been replaced by digital images A wealth of new illustrations have been added Presents expanded information on processing and image quality Updated to include new information, knowledge gained from continued clinical experience and the most relevant references from recent literature CD included with the book presents all the radiographic images in electronic format Since publication of the Second Edition, there have been major advances in other imaging techniques, including scintigraphy, ultrasonography, computed tomography and magnetic resonance imaging. This third edition still focuses on radiography and radiology, but acknowledges the limitations of radiography in some circumstances. In these situations, reference is made to other imaging techniques which may be appropriate, along with suggestions for further reading.
While many high-income countries observe a relative decline in the population impact of heart disease and deal with the problem of an older patient population who readily survive earlier non-fatal encounters with the condition, Africa contends with a typically younger population with frequently advanced and often fatal heart disease. While high-income countries exclusively deal with non-communicable forms of heart disease, Africa contends with both communicable and non-communicable forms of heart disease. Designed to provide anyone with an interest in heart disease in Africa with an immediate sense of how the area is progressing from a clinical to research perspective in responding to this evolving epidemic Presents salient research uncovering the evolving burden of communicable and non-communicable forms of heart disease, Includes content on maternal heart disease, infant and childhood heart disease, risk and prevention, heart failure and other common forms of heart disease in rural and urban communities in Africa.
Packed with Board-focused hints, case studies and an online Board-standard MCQ test offering CME credits, this fantastic book covers every gastroenterology disease and symptom you’re likely to encounter and is the perfect tool to prepare for Board exams and certification.