Compassionate missions constitutes a growing focus among evangelical denominations and agencies. Because of this, there exists a growing need to be guided by sound principles and best practices. This edited volume sets forth both the biblical foundations and preferred methods for churches wanting to engage in compassion as part of their missionary efforts. The aim throughout is that compassionate missions would be guided by indigenous principles that help establish autonomous local churches, capable of being salt and light in their communities. The contributors to this volume have over 200 years of missions experience. Through their first-hand knowledge of the challenges and pitfalls faced by missionaries engaging in compassion, these authors set forth foundational principles and practical guidelines related to some of the most pressing issues confronting missionaries today. These include HIV/AIDS, UPGs, human trafficking, orphans and vulnerable children, gender issues, and many more. Pastors, missionaries, missions boards, and educators will find this a valuable resource as the church in the twenty-first century continues to engage in the Great Commission.