Aspartic Acid Proteases as Therapeutic Targets. Hugo Kubinyi
Медицина.
Aspartic Acid Proteases as Therapeutic Targets
Год выпуска 0
isbn 9783527630950
Автор произведения Hugo Kubinyi
Жанр Медицина
Издательство John Wiley & Sons Limited
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.