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Список книг автора Группа авторовVenoms to Drugs
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
The Growing Power of Japan, 1967-1972
John Pilcher’s appointment as HM Ambassador to Japan in 1967, three years after the widely acclaimed Tokyo Olympics, was both judicious and enlightened. His role was to be that of a bridge-builder between Japan and Britain following the early post-war years of disenchantment, distrust and detachment that had earlier marked the relationship between the two countries. He brought to his role a particular understanding of Japanese civilization and a critical analysis of Japanese attitudes and way of life. Before the war he had had the good fortune to spend time as a language student in Kyoto. There he came to appreciate Japanese culture at its best but as a junior consular official he also came to see other less attractive aspects of Japan. In this volume Sir Hugh Cortazzi who was to follow in John Pilcher’s footsteps, has compiled the defining reports to Whitehall from Pilcher’s time and as such they offer a valuable record of Japan’s progress at this important point in her post-war history, as well as providing unique insights into the activities, hopes and expectations of the British government in her dealings with Japan. The collection (including essays and writings from his private papers) which has hitherto remained largely unknown or inaccessible to most researchers, provides a platform for John Pilcher as a writer and distinguished scholar-diplomat.
Britain and Japan: Biographical Portraits, Vol. IX
Published in association with the Japan Society and containing 57 essays, this ninth volume in the series continues to celebrate the life and work of the men and women, both British and Japanese, who over time played an interesting and significant role in a wide variety of different spheres relating to the history of Anglo-Japanese relations and deserve to be recorded and remembered. Read together they give a picture, even if inevitably a partial one, of important facets of modern history and Anglo-Japanese institutions. They shed light on a number of controversial issues as well as illuminate past successes and failures. Structured thematically in four Parts – Japan in Britain, Britain in Japan, Scholars and Writers, Politicians and Officials – the highlights in this volume include: The Great Japan Exhibition, 1981-82; Japanese Gardens and the Japanese Garden Society in the UK; Cricket in Late Edo and Meiji Japan; Norman Macrae, pioneering journalist of The Economist; Arthur Balfour – managing the emergence of Japan as a Great Power; Michio Morishima, an economist ‘made in Japan’; Margaret Thatcher – a pragmatist who radically improved Britain’s image in Japan.
Comprehensive Review in Vascular and Endovascular Medicine
Comprehensive Review in Vascular and Endovascular Medicine provides a primer for clinicians from various disciplines who care for patients with vascular disease. Written by a multidisciplinary panel of nationally and internationally recognized experts, this book incorporates the latest information on medical, endovascular, and surgical therapies. Features include: an evidence-based approach that emphasizes landmark trials and guidelines; key points that summarize critical knowledge; video clips that highlight significant diagnostic findings and interventional approaches; case studies or board questions to help the reader integrate material. The text has been endorsed by the Society for Vascular Medicine and Vascular Interventional Advances.
Transradial Access: Techniques for Diagnostic Angiography and Percutaneous Intervention
Transradial Access: Techniques for Diagnostic Angiography and Percutaneous Intervention offers a single source for both novice and experienced interventional cardiologists for safely and effectively performing transradial catheterization procedures. First described in 1989, the transradial approach for coronary angiography and percutaneous interventions has seen a constant and progressive increase around the world as a result of significantly reduced procedural complications, shorter hospital stays, increased patient satisfaction, and lower associated costs compared with the transfemoral approach.
Yet despite its apparent benefits, adoption of this technique in the United States has been slow, largely due to the increased technical aspects of entering a smaller artery, accessing the central circulation and engaging the coronary arteries from this approach. In addition, until recently the technique was not routinely taught in the majority of training programs. This book flattens that learning curve by highlighting the technical aspects of transradial diagnostic and interventional procedures, and includes detailed discussion of:
Normal vascular anatomy of the hand and arm Indications and contraindications for transradial access procedures Patient and catheter selection Tips and tricks for both beginner and advanced operators Procedural pitfalls and potential complications
Techniques are demonstrated in detail using both still images and video. Whether you are an experienced transfemoral operator who wants to refine and expand your technique or a new transradial operator looking to master the technique, this comprehensive text holds the key to mastering this revolutionary procedure.
The Cardiorenal Syndrome : A Clinician's Guide to Pathophysiology and Management
Cardiorenal syndrome – the presence of significant renal insufficiency and heart failure simultaneously – constitutes one of the most vexing and difficult challenges facing clinicians and researchers today. Given the fundamental role of the kidneys in maintaining fluid and electrolyte balance within the body, it comes as no surprise that renal abnormalities are inextricably linked with congestive heart failure. What is surprising is that recent data have indicated that renal dysfunction is a more critical determinant of mortality than heart failure itself.
In The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management, experts from around the world clearly outline the current issues associated with this increasingly prevalent condition, provide invaluable insight into its pathophysiology, and highlight the risks, benefits, and rationales for both practical and promising prevention and treatment strategies, including: • Diuretics • Role of ACE inhibitors/ angiotensin receptor blockers in renal dysfunction • New «designer» peptides for heart failure • Inotropes and neurohormonal blockade • Dialysis and ultrafiltration • Renal cell therapy • Left ventricular assist device implantation • Renal and/or heart transplantation
While recognition of the role of renal dysfunction in the progression of heart failure is a pivotal advance, many questions about the scope and impact of this condition remain. This book serves as a touchstone for cardiovascular specialists and internists as they encounter the diverse varieties of cardiorenal syndrome and attempt to navigate the radically different and evolving therapeutic options in their quest to provide optimal individualized care for their patients.
Transseptal Catheterization and Interventions
The first comprehensive resource on transseptal catheterization.
Although the transseptal technique was described half a century ago, it has remained essentially unchanged. Recent advances in cardiac electrophysiology and left heart interventions have led to renewed interest in the technique as a means of delivering modern therapeutic interventions.
Until now, the knowledge required for safely gaining access to the left atrium to perform catheter ablation for atrial fibrillation or other interventions has existed only in original publications and review articles. This textbook brings all of the relevant information about this technique under one cover, with top experts in each area addressing anatomy, indications, transseptal puncture, visualization technologies, interventional devices, challenging cases, complications, and emerging tools. Electrophysiologists and interventional cardiologists will find Transseptal Catheterization and Interventions invaluable for their work. For teachers and trainees, it will be a welcome teaching tool and resource.
Transseptal Catheterization and Interventions was listed by the American Journal of Cardiology as one of the «Good Books in Cardiovascular Disease in 2010». – American Journal of Cardiology Vol. 107, Issue 8, Pages 1250-1251
Transseptal left heart catheterization is here to stay. It already plays an important role in the repertoire of both interventional cardiologists and clinical electrophysiologists, and it will play an increasingly important role in the future.
Perinatal Cardiology: A Multidisciplinary Approach
Perinatal cardiology is an important developing field as high quality ultrasound is used on a growing number of pregnant women, and diagnosis prior to birth will become a more common occurrence. In addition, highly sensitive noninvasive diagnostic tools, advances in neonatal care and anesthesia, evolution of transcatheter interventional procedures and performance of complicated surgical procedures in the neonate and young infant have advanced to such an extent that almost all congenital cardiac defects can be diagnosed and “corrected.” Illustrated with over 500 figures, this book by leaders in the fields of pediatric cardiology, neonatology, pediatric cardiovascular surgery and interventional pediatric cardiology focuses on congenital heart defect issues during the perinatal period: prenatal (before birth) and neonatal (first month after birth). This book discusses the three major areas of perinatal cardiology: 1. Provides an overview of advances in perinatology, neonatology, cardiology and cardiac surgery in making early diagnosis and offering treatment options for patients with CHD. 2. The concept of the multidisciplinary approach to managing infants with congenital cardiac lesion. 3. Evidence-based therapeutic approaches to successfully treat the fetus and the newborn with congenital cardiac lesions.
Hot Topics in Financial and Legal Matters for General Practice
Medical practice is not only a specialist occupation but also a business. Practice finance and law are complex matters and it is becoming increasingly difficult to run a successful practice in the present climate. With the pressures facing GPs and practice managers at an all-time high it is now essential to work ‘on’ as well as ‘in’ the practice. To do this practices need to reorganise to create time to undertake these hugely important tasks. This compendium of hot topics around accounting, banking and legal issues will be of enormous use to practice managers and GPs. The topics have been carefully selected to be as up to date and applicable to current issues as possible. The topics include: changes to the GP contract and their financial impact, tax returns, partnership roles, disputes and changes, incorporation, practice mergers and federations, GP property ownership, loans, security and overdrafts, recruitment of partners, salaried GPs and locums, retirement and pensions, the types of private work available. The easy-to-read topics are support by worked examples and tables throughout. This book will assist with the success of a practice in terms of earnings, quality of life and indeed patient care. It will help GPs and practice managers find and take the time to work ‘on’ as well as ‘in’ the business.
The Good GP Training Guide
The Good GP Training Guide is a travel guide-style book for trainees in general practice. Written by over a hundred contributors assembled from five continents, it includes contributions from leading writers in primary care. It is written in an accessible style with down-to-earth tips and anecdotes, sometimes irreverent, from real life. There is an emphasis on the reality of general practice. It also contains humorous or touching vignettes with accompanying linocut artwork from the Red Roses exhibition. The book's first section covers hospital placements. It is intended to show trainees how to get the most out of their training posts. Beginning with basic information on behaviour required in the hospital setting, there are chapters looking at cardiology, ophthalmology, rheumatology, etc. These chapters are split up into handy lists, covering the basics, tips on patients and PDP pointers. The second section covers GP rotations. It gives information on passing the various RCGP exams as well as realistic advice on other facets of general practice. The third section looks at finding a job and making the transition to an independent practitioner. Options for broadening a doctor's career are looked here, with chapters on event medicine, academia, teaching, etc. There is information on how stay out of trouble and how to use social media safely and without running foul of the GMC. The book offers the ultimate guide to the training process. It covers the entire training experience and the practicalities of what comes after.