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    Veterinary Comparative Hematopathology

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    Hematopoietic neoplasms are the most common animal tumors for which chemo- or radiation therapy are now given. New research, information, and images unavailable in any previous publication now make it possible to examine these diseases, categorize for treatment, and in some cases ascertain the impact on survival. A ground-breaking book in veterinary medicine, Veterinary Comparative Hematopathology is a heavily illustrated comprehensive reference on hematopoietic neoplasms in domestic and laboratory animals. The book enables veterinary pathologists and oncologists to provide more specificity in both diagnosis and therapy, and will serve as a seminal reference for future work in the field. The book offers a unique comparative approach based on the WHO classification of these tumors in humans. Known animal tumors are described and compared to their counterparts in humans. Those tumors now defined in humans but without a recognized animal counterpart are described in the human context, thus better facilitating future identification in animals. Ground-breaking book in veterinary medicine Over 1400 color images Comprehensive reference for veterinary pathologists and oncologists Unique comparative approach makes this a seminal text on animal tumors

    Measuring Health Care

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    This invaluable guide shows students and professionals how measurements and data can be used to balance quality services and financial viability and how measures can help to evaluate and improve organizational, clinical, and financial processes. The book explains the various performance measurement methods used in health care and shows their practical impact on clinical patient outcomes.

    Continuing Professional Development

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    Therapists must increase their understanding of Continuing Professional Development (CPD) to maintain and improve competence. Every practitioner will need to take steps to maintain and demonstrate continued competence under the provisions of the new Health Act 1999. This book considers current policy on CPD and discusses the theoretical basis for maintaining competence and for adult learning. Primarily, however, it provides practical guidance on how to develop a strategy for professional and career development, and on portfolio preparation that shows evidence of professional updating and CPD. Many examples are given of activities in the areas of clinical work, management, education and research that can be used for CPD. The development and use of learning skills such as reflection and critical evaluation is considered central to the process. Written specifically with the therapist in mind, this book will provide invaluable practical advice to occupational therapists, physiotherapists, radiographers, speech and language therapists, and podiatrists.

    Introduction to Syndemics

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    This book explains the growing field of syndemic theory and research, a framework for the analysis and prevention of disease interactions that addresses underlying social and environmental causes. This perspective complements single-issue prevention strategies, which can be effective for discrete problems, but often are mismatched to the goal of protecting the public's health in its widest sense. «Merrill Singer has astutely described why health problems should not be seen in isolation, but rather in the context of other diseases and the social and economic inequities that fuel them. An important read for public health and social scientists.» —Michael H. Merson, director, Duke Global Health Institute «Not only does this book provide a persuasive theoretical biosocial model of syndemics, but it also illustrates the model with a wide variety of fascinating historical and contemporary examples.» —Peter J. Brown, professor of Anthropology and Global Health and director, Center for Health, Culture, and Society, Emory University «The concept of syndemics is Singer's most important contribution to critical medical anthropology as it interfaces with an ecosocial approach to epidemiology.» —Mark Nichter, Regents Professor, Department of Anthropology, University of Arizona «Merrill Singer offers the public the most comprehensive work ever written on this key area of research and policy making.» —Francisco I. Bastos, chairman of the graduate studies on epidemiology, Fundacao Oswaldo Cruz «Exquisitely describes how this new approach is a critical tool that brings together veterinary, medical, and social sciences to solve emerging infectious and non-infectious diseases of today's world.» —Bonnie Buntain, MS, DVM, diplomate, American College of Veterinary Preventive Medicine «For too long the great integrative perspectives on modern biomedicine and public health disease ecology and social medicine-have remained more or less separate. In this innovative and provocative book, Merrill Singer develops a valuable synthesis that will reshape the way we think about health and disease.» —Warwick H. Anderson, MD, PhD, professorial research fellow, Department of History and Centre for Values, Ethics, and the Law in Medicine, University of Sidney

    Health Information Management

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    This is the fifth edition of the definitive reference source on the management of health records. Health Information Management provides the basic guidelines on content and structure, analysis, assessment, and improvement of information critical to every health care organization. This thoroughly revised and updated edition reflects the significant changes in the field and the most current and successful practices most notably, the computerization of record operations and systems, and of the record itself.

    Public Health Genomics

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    The Centers for Disease Control (CDC) has recognized genomics as a priority area in public health education. To help public health students and professionals achieve proficiency in the language of genetics and attain genomics competencies delineated by the CDC, this book offers an introduction to basic molecular genetics and discusses the relevance of genomics to such key public health issues as environmental health, ethnic health disparities, health policy and law, research ethics, maternal and child health, clinical preventive medicine, health behavior, health economics, and communicable disease control. Presented in a context that is easy to understand, the book serves as an accessible portal of entry into the world of public health genomics.

    Human Drug Metabolism

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    Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine. This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.

    Preclinical Development Handbook

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    A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

    Preclinical Development Handbook

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    A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

    High Content Screening

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    The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.