Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal

      

      Table of Contents

      1  COVER

      2  TITLE PAGE

      3  COPYRIGHT PAGE

      4  LIST OF CONTRIBUTORS

      5  FOREWORD

      6  PREFACE

      7  CHAPTER 1: INTRODUCTION: AN OVERVIEW OF NANOSIZED EMULSIONS 1.1. INTRODUCTION 1.2. CONCLUSION REFERENCES

      8  CHAPTER 2: FORMULATION DEVELOPMENT OF OIL‐IN‐WATER NANOSIZED EMULSIONS 2.1. INTRODUCTION 2.2. FDA‐APPROVED OILS, EMULSIFIERS, AND AUXILIARY OR MISCELLANEOUS EXCIPIENTS 2.3. CURRENT AND NEAR FUTURE DIRECTION 2.4. LIPOPHILIC API INCORPORATION PATTERN INTO NANOSIZED EMULSIONS 2.5. QbD APPROACH TO OPTIMIZE EMULSION 2.6. CONCLUSION REFERENCES

      9  CHAPTER 3: CHARACTERIZATION AND SAFETY ASSESSMENT OF OIL‐IN‐WATER NANOSIZED EMULSIONS 3.1. INTRODUCTION 3.2. PHYSICAL AND VISUAL EVALUATIONS 3.3. CHEMICAL AND BIOLOGICAL EVALUATIONS 3.4. SAFETY AND EFFICACY ASSESSMENTS 3.5. CONCLUSION REFERENCES

      10  CHAPTER 4: MANUFACTURING AND POSITIONING (GENERATIONS) OF OIL‐IN‐WATER NANOSIZED EMULSIONS 4.1. INTRODUCTION 4.2. GENERATIONS OF O/W NANOSIZED EMULSIONS 4.3. PREPARATION METHODS FOR API‐FREE/LOADED O/W NANOSIZED EMULSIONS 4.4. CONCLUSION REFERENCES

      11  CHAPTER 5: BIOFATE OF NANOSIZED EMULSIONS 5.1. INTRODUCTION 5.2. BIOFATE OF O/W NANOSIZED EMULSIONS 5.3. CLINICAL ISSUES OF FIRST‐GENERATION NANOSIZED EMULSIONS 5.4. CONCLUSION REFERENCES

      12  CHAPTER 6: MEDICAL OR THERAPEUTICAL APPLICATIONS OF OIL‐IN‐WATER NANOSIZED EMULSIONS 6.1. INTRODUCTION 6.2. MEDICAL OR THERAPEUTICAL APPLICATIONS OF O/W NANOSIZED EMULSIONS 6.3. CONCLUSION REFERENCES

      13  PART I: OVERVIEW OF TOCOL‐BASED EMULSIONS, OXYGEN‐CARRYING EMULSIONS, EMULSIONS WITH DOUBLE OR TRIPLE CARGOS AND EMULSION‐LIKE DISPERSIONS CHAPTER 7: OVERVIEW OF TOCOL‐BASED EMULSIONS, OXYGEN‐CARRYING EMULSIONS, EMULSIONS WITH DOUBLE OR TRIPLE CARGOS AND EMULSION‐LIKE DISPERSIONS CHAPTER 7.1: TOCOL‐BASED NANOSIZED EMULSIONS 7.1.1. INTRODUCTION 7.1.2. FORMULATION DEVELOPMENT USING TOCOL 7.1.3. NON‐ AND PRE‐CLINICAL SAFETY STUDIES 7.1.4. THERAPEUTIC APPLICATIONS 7.1.5. CONCLUSION REFERENCES CHAPTER 7.2: OXYGEN‐CARRYING EMULSIONS 7.2.1. INTRODUCTION 7.2.2. RATIONALE FOR SELECTING PERFLUOROCARBON FOR IN VIVO OXYGEN TRANSPORT 7.2.3. FORMULATION OF STABLE INJECTABLE PERFLUOROCARBON EMULSIONS 7.2.4. MULTIFUNCTIONAL PERFLUOROCARBON‐BASED EMULSIONS 7.2.5. GENERATIONS AND HURDLES OF PERFLUOROCARBON‐BASED NANOSIZED EMULSIONS AS OXYGEN CARRIERS 7.2.6. PROPOSED SOLUTIONS TO OVERCOME THE HURDLES OF PERFLUOROCARBON‐BASED NANOSIZED EMULSIONS USED AS OXYGEN CARRIERS 7.2.7. CONCLUSION REFERENCES CHAPTER 7.3: NANOSIZED EMULSIONS FOR MULTIPLE MEDICAMENT LOADINGS, IMAGING, AND THERANOSTIC PURPOSES 7.3.1. INTRODUCTION 7.3.2. BRIEF REVIEW OF RESEARCH REPORTS ON NANOSIZED EMULSIONS FOR IMAGING AND THERANOSTIC PURPOSE 7.3.3. VARIOUS TOPOLOGIES OBSERVED IN DISPERSED OIL DROPLETS OF THE EMULSIONS 7.3.4.