Practical Breast Pathology. Tibor Tot

entire TDLU is filled by the monomorphous small cells, the lesion is considered to be ductal carcinoma in situ (DCIS) grade I. ADH differs from DCIS grade I through extent and distribution, not through cellular features.

      Fig. 3.8

      During the evolution of DCIS, different cell clones may appear within the initially monoclonal tumor cell population leading to a multiclonal malignant cell population. These lesions are grade II or grade III DCIS and consist of a population of large polymorphous cells (Fig. 3.9).

      Fig. 3.9

      

      Architectural Features