Principles in Microbiome Engineering. Группа авторов

      13  9 Maternal Microbiota as a Therapeutic Target 9.1 Introduction 9.2 Human Maternal Microbiota 9.3 Maternal Microbiota and Health 9.4 Human Milk Microbiota and Infant Health 9.5 Drug Treatment, Unhealthy Conditions, and Microbiome 9.6 Probiotic and Prebiotic Therapies as Modulators of Microbiome References

      14  10 Transcription Factor‐Based Biosensors and Their Application in Microbiome Engineering Summary 10.1 Design: TF‐Based Biosensors 10.2 Build: TF‐Based Biosensors 10.3 Test: TF‐Based Biosensors Application in Microbiome 10.4 Learn: Strategies for TF‐Based Biosensor Improvement 10.5 Conclusions Acknowledgments References Note

      15  Index

      16  Wiley End User License Agreement

      List of Tables

      1 Chapter 1Table 1.1 Effects of dietary protein on host‐gut microbiota.Table 1.2 Effects of natural and artificial sugar on gut microbiota.Table 1.3 Effect of non‐digestible carbohydrates on gut microbiota.Table 1.4 Effect of dietary fat on gut microbiota.Table 1.5 Infrastructures supporting microbiome research.

      2 Chapter 2Table 2.1 Examples of gut microbiome and metabolites associated with psychi...Table 2.2 Preclinical studies for different diseases with the probiotics us...Table 2.3 Clinical studies for different diseases with the probiotics used ...

      3 Chapter 3Table 3.1 Microbial diagnostics for the detection of disease states.

      4 Chapter 5Table 5.1 Summary of the popular tools for analyzing ‐omics data.

      5 Chapter 6Table 6.1 Recent examples of engineered biosensing probiotics.

      6 Chapter 8Table 8.1 A list of FMT donor‐screening studies.

      7 Chapter 9Table 9.1 Gut microbiota during pregnancy.Table 9.2 Factors that influence the breast milk microbiota.

      8 Chapter 10Table 10.1 Transcription factor (TF)‐based biosensors for microbiome applic...

      List of Illustrations

      1 Chapter 1Figure 1.1 The average adult human microbiota composition of five body sites...Figure 1.2 The socioeconomic impact on dietary habits. (a) The schematic of ...Figure 1.3 The composition of the gut microbiome in people at different age ...Figure 1.4 Dietary perturbation of the microbiome to improve human health. T...Figure 1.5 Protocol of FMT. Stool from healthy donors are screened and teste...

      2 Chapter 2Figure 2.1 (a) Number of publications over the years with keywords shown in ...Figure 2.2 Engineering approaches to modulate microbiome functions and vario...Figure 2.3 Integrated metabolism of key metabolites by the host and gut micr...Figure 2.4 Pathway for the translation of live biotherapeutic products (LBPs...

      3 Chapter 3Figure 3.1 Impacts of gut microbiota on human metabolism and physiology. (a)...Figure 3.2 Notable characteristics essential for efficient colonization of B...Figure 3.3 Use of microbes for diagnostic and therapeutic purposes. (a) E. c...Figure 3.4 Systems biology approaches to characterize the gut microbiome. Me...

      4 Chapter 4Figure 4.1 Highlighted strategies to modulate probiotic delivery site and re...

      5 Chapter 5Figure 5.1 Schematic illustrating the “Design–Build–Test–Learn” approach use...

      6 Chapter 6Figure 6.1 General schematics of riboswitch regulatory mechanisms. Bacterial...Figure 6.2 Schematics of the transcription factor regulatory mechanisms. The...Figure 6.3 General schematic of a TCS. Upon ligand binding, the sensor kinas...Figure 6.4 General schematic of a GPCR‐based sensor in yeast. The endogenous...Figure 6.5 Schematic of the cell‐free protein expression process using a cru...Figure 6.6 The gut‐on‐a‐chip model is constructed using the Emulate Bio micr...Figure 6.7 Potential molecular discovery analyses or characterization utiliz...

      7 Chapter 7Figure 7.1 (a) Top‐down approaches take consortia with their full complexity...Figure 7.2 (a) In a single‐cell system, the cell must produce all components...Figure 7.3 Tools that have enabled rapid development and improvement in cons...

      8 Chapter 8Figure 8.1 Mechanisms of FMT in patients with recurrent, severe, or therapy‐...

      9 Chapter 10Figure 10.1 A design–build–test–learn (DBTL) cycle of genetically encoded bi...

      Guide

      1  Cover

      2  Table of Contents

      3  Title Page

      4  Copyright

      5  Preface

      6  Begin Reading

      7  Index