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      Routes to Essential Medicines

      A Workbook for Organic Synthesis

       Peter J. Harrington

       Better Pharma Processes, LLC

       Louisville, CO, USA

      This edition first published 2022

      © 2022 John Wiley & Sons, Inc.

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Peter J Harrington to be identified as the author of this work has been asserted in accordance with law.

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       Library of Congress Cataloging‐in‐Publication Data applied for:

      ISBN: 9781119722861

      Cover image: [Production Editor to insert]

      Cover design by [Production Editor to insert]

       This workbook is dedicated to everyone who made it their mission in life to discover and manufacture Essential Medicines and to: Professor Louis S. Hegedus

       Who inspired this workbook project with a lesson learned at Colorado State University: An hour in the library will save you from two weeks of floundering around in the laboratory.

      About the Companion Website

       www.wiley.com/go/Harrington/routes_essential_medicine

      Introduction

While teaching undergraduate Organic Chemistry at University of Colorado, I was asked if I could teach a course in organic synthesis. I have worked as synthetic organic chemist and educator for my entire career (Princeton University, Colorado State University, SUNY Binghamton, Syntex, Roche, University of Denver, University of Colorado, and Better Pharma Processes, LLC) but I realized I was not prepared to teach the course. This workbook project began with that missed opportunity.

      In my first Organic Chemistry class at Canisius College more than forty years ago, I recognized the power synthetic organic chemists have to create new medicines to improve human healthcare. With great power comes great responsibility. The synthetic organic chemistry community accepted this responsibility: the result is our World Health Organization (WHO) Model List of Essential Medicines.

      Routes to Essential Medicines: A Workbook for Organic Synthesis highlights the synthetic organic chemistry in the manufacturing routes of nearly three hundred medicines on the World Health Organization (WHO) Model List of Essential Medicines (20th List from March 2017). The workbook includes all the medicines on the list for which synthetic organic chemistry plays an important role in the manufacturing process.

      Routes to Essential Medicines: A Workbook for Organic Synthesis is intended for use by upper‐level undergraduate students and graduate students participating in a course in organic synthesis or medicinal chemistry. Students using this workbook will become familiar with the structures and synthetic challenges associated with nearly three hundred essential medicines and gain an appreciation for the manufacture of specialty chemical starting materials. Students who use this workbook will develop a solid foundation for their academic and postacademic research: an extensive favorites list of key journal and information sites and a personal library of reagents,