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This comprehensive and unique handbook of split and splitless injection techniques has been completely revised and updated. This new edition offers: – New insights concerning sample evaporation in the injector – Information about matrix effects – A new chapter on injector design The real processes within the injector are for the first time visualized and explained by the CD-ROM included in the book. Furthermore the reader will understand the concepts of injection techniques and get a knowledge of the sources of error. The handbook also includes many practical guidelines. From reviews of former editions: «This substantial book is on injection techniques alone, which … demonstrates this can have many pitfalls … no one should be allowed to direct a laboratory doing quantitative analysis by GC without first being thoroughly familar with this book …» The Analyst «This is a detailed reference volume filled with practical suggestions and techniques for managing split and splitless injection in the day-to-day world of the working gas chromatographer. It will be useful … for anyone who must work hands-on with GC.» Journal of High Resolution Chromatography
Analytical Methods in Supramolecular Chemistry
An overview of the techniques used to examine supramolecular aggregates from a methodological point of view. Edited by a rising star in the community and an experienced author, this is a definitive survey of useful modern analytical methods for understanding supramolecular chemistry, from NMR to single-molecule spectroscopy, from electron microscopy to extraction methods. A definitive study of this field touching many interdisciplinary areas such as molecular devices, biology, bioorganic chemistry, material science, and nanotechnology.
Quality Assurance in Analytical Chemistry
This best-selling title both in German and English is now enhanced by a new chapter on the important topical subject of measurement uncertainty, plus a CD-ROM with interactive examples in the form of Excel-spreadsheets. These allow readers to gain an even better comprehension of the statistical procedures for quality assurance while also incorporating their own data. Following an introduction, the text goes on to elucidate the 4-phase model of analytical quality assurance: establishing a new analytical process, preparative quality assurance, routine quality assurance and external analytical quality assurance. Besides updating the relevant references, the authors took great care to incorporate the latest international standards in the field.
High-Resolution Continuum Source AAS
High-resolution continuum source atomic absorption spectrometry (HR-CS AAS) is the most revolutionary innovation since the introduction of AAS in 1955. Here, the authors provide the first complete and comprehensive discussion of HR-CS AAS and its application to the analysis of a variety of difficult matrices. Published just in time with the first commercial instrument available for this new technique, the book is a must for all those who want to know more about HR-CS AAS, and in particular for all future users. The advantages of the new technique over conventional line-source AAS are clearly demonstrated using practical examples and numerous figures, many in full color. HR-CS AAS is overcoming essentially all the remaining limitations of established AAS, particularly the notorious problem of accurate background measurement and correction. Using a continuum radiation source and a CCD array detector makes the spectral environment visible to several tenths of a nanometer on both sides of the analytical line, tremendously facilitating method development and elimination of interferences. Conceived as a supplement to the standard reference work on AAS by B. Welz and M. Sperling, this book does not repeat such fundamentals as the principles of atomizers or atomization mechanisms. Instead, it is strictly focused on new and additional information required to profit from HR-CS AAS. It presents characteristic concentration for flame atomization and characteristic mass data for electrothermal atomization for all elements, as well as listing numerous secondary lines of lower sensitivity for the determination of higher analyte concentrations. The highly resolved molecular absorption spectra of nitric, sulfuric and phosphoric acids, observed in an air-acetylene flame, which are depicted together with the atomic lines of all elements, make it possible to predict potential spectral interferences.
Method Validation in Pharmaceutical Analysis
Adopting a practical approach, the authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book thus allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness. Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the whole analytical quality assurance system. The whole is rounded off with a look at future trends. With its first-hand knowledge of the industry as well as regulating bodies, this is an invaluable reference for analytical chemists, the pharmaceutical industry, pharmaceutists, QA officers, and public authorities.
Statistical Treatment of Analytical Data
Statistical techniques have assumed an integral role in both the interpretation and quality assessment of analytical results. In this book the range of statistical methods available for such tasks are described in detail, with the advantages and disadvantages of each technique clarified by use of examples. With a focus on the essential practical application of these techniques the book also includes sufficient theory to facilitate understanding of the statistical principles involved. Statistical Treatment of Analytical Data is written for professional analytical chemists in industry, government and research institutions who require a practical understanding of the application of statistics in day to day activities in the analytical laboratory. It is also for students who require further and detailed information that may not be available directly in a typical undergraduate course.
Modern HPLC for Practicing Scientists
A comprehesive yet concise guide to Modern HPLC Written for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers. Topics covered include: HPLC operation Method development Maintenance and troubleshooting Modern trends in HPLC such as quick-turnaround and «greener» methods Regulatory aspects While broad in scope, this book focuses particularly on reversed-phase HPLC, the most common separation mode, and on applications for the pharmaceutical industry, the largest user segment. Accessible to both novice and intermedate HPLC users, information is delivered in a straightforward manner illustrated with an abundance of diagrams, chromatograms, tables, and case studies, and supported with selected key references and Web resources. With intuitive explanations and clear figures, Modern HPLC for Practicing Scientists is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology.
Statistical Methods in Analytical Chemistry
This new edition of a successful, bestselling book continues to provide you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate experimental design and data evaluation methods. Unlike other books on the subject, Statistical Methods in Analytical Chemistry, Second Edition presents and solves problems in the context of a comprehensive decision-making process under GMP rules: Would you recommend the destruction of a $100,000 batch of product if one of four repeat determinations barely fails the specification limit? How would you prevent this from happening in the first place? Are you sure the calculator you are using is telling the truth? To help you control these situations, the new edition: * Covers univariate, bivariate, and multivariate data * Features case studies from the pharmaceutical and chemical industries demonstrating typical problems analysts encounter and the techniques used to solve them * Offers information on ancillary techniques, including a short introduction to optimization, exploratory data analysis, smoothing and computer simulation, and recapitulation of error propagation * Boasts numerous Excel files and compiled Visual Basic programs-no statistical table lookups required! * Uses Monte Carlo simulation to illustrate the variability inherent in statistically indistinguishable data sets Statistical Methods in Analytical Chemistry, Second Edition is an excellent, one-of-a-kind resource for laboratory scientists and engineers and project managers who need to assess data reliability; QC staff, regulators, and customers who want to frame realistic requirements and specifications; as well as educators looking for real-life experiments and advanced students in chemistry and pharmaceutical science. From the reviews of Statistical Methods in Analytical Chemistry, First Edition: «This book is extremely valuable. The authors supply many very useful programs along with their source code. Thus, the user can check the authenticity of the result and gain a greater understanding of the algorithm from the code. It should be on the bookshelf of every analytical chemist.»-Applied Spectroscopy «The authors have compiled an interesting collection of data to illustrate the application of statistical methods . . . including calibrating, setting detection limits, analyzing ANOVA data, analyzing stability data, and determining the influence of error propagation.»-Clinical Chemistry «The examples are taken from a chemical/pharmaceutical environment, but serve as convenient vehicles for the discussion of when to use which test, and how to make sense out of the results. While practical use of statistics is the major concern, it is put into perspective, and the reader is urged to use plausibility checks.»-Journal of Chemical Education «The discussion of univariate statistical tests is one of the more thorough I have seen in this type of book . . . The treatment of linear regression is also thorough, and a complete set of equations for uncertainty in the results is presented . . . The bibliography is extensive and will serve as a valuable resource for those seeking more information on virtually any topic covered in the book.»-Journal of American Chemical Society "This book treats the application of statistics to analytical chemistry in a very practical manner. [It] integrates PC computing power, testing programs, and analytical know-how in the context of good manufacturing practice/good laboratory practice (GMP/GLP) . . .The book is of value in many fields of analytical chemistry and should be available in all r
Quadrupole Ion Trap Mass Spectrometry
A definitive reference, completely updated Published in 1989, the First Edition of this book, originally entitled Quadrupole Storage Mass Spectrometry, quickly became the definitive reference in analytical laboratories worldwide. Revised to reflect scientific and technological advances and new applications in the field, the Second Edition includes new chapters covering: * New ion trap instruments of high sensitivity * Peptide analysis by liquid chromatography/ion trap tandem mass spectrometry * Analytical aspects of ion trap mass spectrometry combined with gas chromatography * Simulation of ion trajectories in the ion trap One additional chapter discusses the Rosetta mission, a «comet chaser» that was sent on a ten-year journey in 2004 to study the comet Churyumov-Gerasimenko using, among other instruments, a GC/MS system incorporating a specially designed ion trap mass spectrometer. This comprehensive reference also includes discussions of the history of the quadrupole ion trap, the theory of quadrupole mass spectrometry, the dynamics of ion-trapping chemistry in the quadrupole ion trap, the cylindrical ion trap, miniature traps, and linear ion traps. Complete with conclusions and references, this primer effectively encapsulates the body of knowledge on quadrupole ion trap mass spectrometry. With its concise descriptions of the theory of ion motion and the principles of operation, Quadrupole Ion Trap Mass Spectrometry, Second Edition is ideal for new users of quadrupole devices, as well as for scientists, researchers, and graduate and post-doctoral students working in analytical laboratories.
The Electron Capture Detector and The Study of Reactions With Thermal Electrons
Broad in scope, this book describes the general theory and practice of using the Electron Capture Detector (ECD) to study reactions of thermal electrons with molecules. It reviews electron affinities and thermodynamic and kinetic parameters of atoms, small molecules, and large organic molecules obtained by using various methods. * Summarizes other methods for studying reactions of thermal electrons with molecules * Discusses applications in analytical chemistry, physical chemistry, and biochemistry * Provides a data table of electron affinities