Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураDynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science
Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover: Basic theory Approaches to binding in proteins and nucleic acids Molecular recognition Self-sorting Catalyst discovery Materials discovery Analytical chemistry challenges A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.
Electrospray and MALDI Mass Spectrometry. Fundamentals, Instrumentation, Practicalities, and Biological Applications
Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.
Practical Relativity. From First Principles to the Theory of Gravity
The book is intended to serve as lecture material for courses on relativity at undergraduate level. Although there has been much written on special relativity the present book will emphasize the real applications of relativity. In addition, it will be physically designed with the use of box summaries so as to allow easy access of practical results. The book will be composed of eight chapters. Chapter 1 will give an introduction to special relativity that is the world without gravity. Implications will be presented with emphasis on time dilation and the Doppler shift as practical considerations. In Chapter 2, the four-vector representation of events will be introduced. The bulk of this chapter will deal with flat space dynamics. This will require the generalization of Newton's first and second laws. Some important astronomical applications will be discussed in Chapter 3 and in Chapter 4 some engineering applications of special relativity such as atomic clocks will be presented. Chapter 5 will be dedicated to the thorny question of gravity. The physical motivation of the theory must be examined and the geometrical interpretation presented. Chapter 6 will present astronomical applications of relativistic gravity. These include the usual solar system tests; light bending, time delay, gravitational red-shift, precession of Keplerian orbits. Chapter 7 will be dedicated to relativistic cosmology. Many of the standard cosmological concepts will be introduced, being mathematically simple but conceptually subtle. The concluding chapter will be largely dedicated to the global positioning system as an engineering problem that requires both inertial and gravitational relativity. The large interferometers designed as gravitational wave telescopes will be discussed here.
Introducing Proteomics. From Concepts to Sample Separation, Mass Spectrometry and Data Analysis
Introducing Proteomics gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences. This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study. The text covers the following: Separation Technologies Analysis of Peptides/Proteins by Mass Spectrometry Strategies in Proteomics This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, Introducing Proteomics includes extensive references and a list of relevant proteomics information sources; essential for any student. This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems. «I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues.» —Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website www.wiley.com/go/lovric
Blog Theory. Feedback and Capture in the Circuits of Drive
Blog Theory offers a critical theory of contemporary media. Furthering her account of communicative capitalism, Jodi Dean explores the ways new media practices like blogging and texting capture their users in intensive networks of enjoyment, production, and surveillance. Her wide-ranging and theoretically rich analysis extends from her personal experiences as a blogger, through media histories, to newly emerging social network platforms and applications. Set against the background of the economic crisis wrought by neoliberalism, the book engages with recent work in contemporary media theory as well as with thinkers such as Giorgio Agamben, Jean Baudrillard, Guy Debord, Jacques Lacan, and Slavoj ?i?ek. Through these engagements, Dean defends the provocative thesis that reflexivity in complex networks is best understood via the psychoanalytic notion of the drives. She contends, moreover, that reading networks in terms of the drives enables us to grasp their real, human dimension, that is, the feelings and affects that embed us in the system. In remarkably clear and lucid prose, Dean links seemingly trivial and transitory updates from the new mass culture of the internet to more fundamental changes in subjectivity and politics. Everyday communicative exchangesÑfrom blog posts to text messagesÑhave widespread effects, effects that not only undermine capacities for democracy but also entrap us in circuits of domination.
Ethnography Essentials. Designing, Conducting, and Presenting Your Research
A comprehensive and practical guide to ethnographic research, this book guides you through the process, starting with the fundamentals of choosing and proposing a topic and selecting a research design. It describes methods of data collection (taking notes, participant observation, interviewing, identifying themes and issues, creating ethnographic maps and tables and charts, and referring to secondary sources) and analyzing and writing ethnography (sorting and coding data, answering questions, choosing a presentation style, and assembling the ethnography). Although content is focused on producing written ethnography, many of the principles and methods discussed here also apply to other forms of ethnographic presentation, including ethnographic film. Designed to give basic hands-on experience in the overall ethnography research process, Ethnography Essentials covers a wealth of topics, enabling anyone new to ethnography research to successfully explore the excitement and challenges of field research.
Making Sense of Agile Project Management. Balancing Control and Agility
The book is intended to provide a much deeper understanding of agile principles, methodologies, and practices to enable project managers to develop a more agile approach and understand how to blend and tailor agile and traditional principles, methodologies, and practices to create an appropriate balance of control and agility to fit a business environment as well as the risks and complexities of any individual project. The book will also provide business managers and leaders an understanding of how to fit agile methodologies into an overall business strategy that provides the right balance of control and agility for their business.
Mirror-Image Asymmetry. An Introduction to the Origin and Consequences of Chirality
An overview of the importance and consequences of asymmetry from molecules to the macroscopic world As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features: An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.
Organic Reaction Mechanisms 2006. An annual survey covering the literature dated January to December 2006
Organic Reaction Mechanisms 2006 is the 42nd volume in this classical series. Every year, an experienced team of authors compiles these reviews, so that the reader can rely on a continuing quality of selection and presentation. Detailed author and subject indexes help the reader to find the information they are looking for. As a new service to the reader, all reaction mechanisms leading to stereospecific products are highlighted. This reflects the interest of synthetic organic chemists in such reactions and the pharmaceutical role of chiral molecules.
The Weather Almanac. A Reference Guide to Weather, Climate, and Related Issues in the United States and Its Key Cities
The Weather Almanac, 12th Edition is a resource for a variety of climate and meteorological data including both domestic and international weather trends, historical weather patterns dating back 1000 years, natural disasters, and a 20 page glossary of weather terminology. The book is complete with detailed maps, pictures, and tables compiling climate data from a variety of sources, including the National Weather Service and the US Geological Survey. Separate sections in The Weather Almanac are devoted to tornadoes, hurricanes, thunderstorms, and lightening, flash floods, and winter storms, and they have been edited from official reports by governmental agencies. The new edition has been updated to include recent disasters such as the 2004 Indian Ocean Tsunami that devastated Indonesia as well as 2005’s Hurricane Katrina. These chapters serve as a basic reference for severe weather and extreme conditions, which can assist in preparing for a weather emergency.