The explanation and implementation of statistical methods for the medical researcher or statistician remains an integral part of modern medical research. This book explains the use of experimental and analytical biostatistics systems. Its accessible style allows it to be used by the non-mathematician as a fundamental component of successful research. Since the third edition, there have been many developments in statistical techniques. The fourth edition provides the medical statistician with an accessible guide to these techniques and to reflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to its subject. There has been a radical reorganization of the text to improve the continuity and cohesion of the presentation and to extend the scope by covering many new ideas now being introduced into the analysis of medical research data. The authors have tried to maintain the modest level of mathematical exposition that characterized the earlier editions, essentially confining the mathematics to the statement of algebraic formulae rather than pursuing mathematical proofs. Received the Highly Commended Certificate in the Public Health Category of the 2002 BMA Books Competition.
This comprehensive, well referenced text provides an up to date review of what is known scientifically about occupational and environmental causes of sickness, disability, and death. It also includes information on the scientific methods used in acquiring this knowledge, making it a complete reference for both clinicians in occupational medicine, and researchers.
This new edition of the benchmark text on clinical pediatric endocrinology still remains at the forefront of world clinical opinion. Furthermore, the style, which has been the hallmark of the book for the last 20 years, has been maintained for this Fifth Edition. New features of this Fifth Edition include: Special new chapters cover the fetal origins of adult disease and the endocrine consequences and management of critical illness Now opens with a basic science section summarizing the mechanisms of hormone action, genomics, proteomics and the application of molecular biology to clinical practice Two new co-editors have been introduced – Peter Clayton and Rosalind Brown Every chapter has been updated
Not just another overview book on endocrinology,How the Endocrine System Works presents a humorous and highly informative collection of nine easy-to-digest «lectures» discussing the fundamental workings of the endocrine system in health and disease. This absorbing addition to the «How it Works» series provides a concise and scientifically reliable introduction to endocrinology without the use of broad glossary terms and extraneous detail that can make a text hard to follow. This book focuses on function rather than anatomy and definition, so that you can reach an appreciation and a clearer understanding of this intricate system. Students will find this book to be the perfect introduction to their entry-level courses, as well as a quick review for exams. Professionals will enjoy the simple approach to a complex topic, and the general reader will satisfy a basic curiosity about the glands and hormones of the human body.
This brand new title in the Lecture Notes series covers a core element of the medical school curriculum. It presents the basic science needed to understand mechanisms of disease and describes the clinical presentations of the disorders associated with different glands, concluding with the relevant investigations and management. Focusing on conditions commonly encountered on the wards and in exams, with key points to aid revision and recall, this new title is perfect as a course companion and is the ideal revision tool for medical students, specialist nurses, and doctors working on endocrinology rotations. Lecture Notes: Endocrinology and Diabetes is also essential for endocrinology trainees approaching the new Knowledge Based Assessment (KBA).
Gastrointestinal function represents an important, and hitherto inappropriately neglected, aspect of diabetes management. Disordered gastrointestinal motor and sensory function occurs frequently in both type 1 and type 2 diabetes and may be associated with gastrointestinal symptoms that adversely affect quality of life. During the last two decades there has been a rapid expansion in knowledge in this area. It is now recognised that upper gastrointestinal motility is pivotal to the regulation of postprandial blood glucose concentrations in both health and patients with diabetes. This book is the first of its kind and was stimulated by the need to consolidate these recent advances, which dictate that a knowledge of gastroenterology as it relates to diabetes is now required of the clinician/diabetologist. Features an organ-specific overview of the epidemiology and pathophysiology of disordered gastrointestinal (including hepatobiliary and pancreatic) function in diabetes mellitus Contains guidelines for the clinician, diabetologist and gastroenterologist for both diagnosis and management Includes a comprehensive description of the relation between gastrointestinal function, gastrointestinal hormones, autonomic nerve function and glycaemic control in animal models Covers the development of new treatment options, particularly those targeted at the reduction of postprandial hyperglycaemia, to optimise glycaemic control This book will be of interest to gastroenterologists, diabetologists, specialist nurses and clinical researchers.
Many foot problems in diabetes can be prevented and often the patients are misdiagnosed, or inappropriately referred or treated. This title will be of immense use to the audience as work of reference. Diabetes mellitus is the lack of insulin leading to uncontrolled carbohydrate metabolism, the breakdown of starches and sugars into smaller units that can be used by the body for energy. Foot ulcers occur in about 15% of diabetic patients in their lifetime and hospital admissions due to foot ulcers are very common. Foot problems mostly occur when there is nerve damage in the feet or when there is poor blood flow. * Contains colour photos and pictures * Examples for identification of the patients at risk for foot ulceration * Prompt diagnosis and treatment.
This book provides a unique and comprehensive synopsis of the prevention and early diagnosis of Type 2 Diabetes. It features articles by key opinion leaders in diabetes from North America, Europe and the Asia-Pacific region who describe the gravity of the problem and the important issue of screening, including contributions on the perspectives of the International Diabetes Federation and the World Health Organization. Once patients at risk have been identified, the key issue is to prevent their progression to full-blown diabetes. Several chapters address this, particularly the difficult task of changing people’s behaviour. Prevention of the complications associated with diabetes involves more targeted interventions, which are discussed by experts in the relevant areas. This book offers both a global perspective and local solutions. Key contributors include Paul Zimmet and Pierre Lefèbvre, President of the International Diabetes Federation who has written a chapter and a foreword. Praise from the reviews: “[A]n excellent resource for professionals who want a good means for getting up to speed on the prevention angle. It is all-inclusive from many perspectives – authorship of chapters, rich reference lists, and content (…). This book is a one-stop source for understanding the state of current prevention knowledge about type 2 diabetes.” DIABETES TECHNOLOGY & THERAPEUTICS «This is a timely and helpful treatment of an important public health topic. I am unaware of any other contemporary books which address exactly this issue.» DOODY'S HEALTH SERVICES «An ambitious title, written by some of the world’s leading diabetologists, it takes a very careful approach ( …)» PEDIATRIC ENDOCRINOLOGY REVIEWS (PER)
This volume outlines what is meant by terms such as 'evidence based practice', 'systematic review', 'efficacy', 'effectiveness'. It summarises, in a systematic fashion, the current evidence on diabetes prevention and care to enable the reader to improve their professional practice. Furthermore, it promotes a critical attitude to the assessment of evidence and engenders enthusiasm for 'lifelong learning'. It also advises clinicians on what to do when there is little available evidence. Chapters consider the evidence base for the definition and classification of diabetes, as well as prevention, identification, treatment, education in IDDM and NIDDM. The final chapters look at the practical implications of translating this evidence into practice in different environments with different health care systems and different economic levels. This is the first book to present an evidence-based approach to diabetes Examines the evidence base for the definition and classification of diabetes, as well as prevention, iden tification, treatment, and education in IDDM and NIDDM Looks at the practical implications of translating this evidence into practice in different environments The editors are leaders in the move towards evidence-based diabetes care
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.