Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.
This book details the rapidly advancing research on the development of the cerebral cortex. Topics covered include: new physiological data showing patterns in developing cortical organization; abnormalities of cortical development associated with psychiatric disorders; and research on cell identity and regionalization of the cortex.
Written for psychologists, educational psychologists and developmental biologists, this volume explores the concept of giftedness, including its definition, origins and development. The author offers a balanced view of the topic and presents optimal educational strategies for various kinds of high ability. The effects of both environmental and biological/genetic factors on a student's level of giftedness are also discussed, as is the question of whether gifted people can be created.
Details the application of positron emission tomography (PET) to the mapping of human cerebral cortical function. Coverage includes all aspects of PET technology. Includes chapters on somatosensory, motor and visual systems, and higher-order processes such as attention, memory, learning, intention and language. The clinical usefulness of PET is discussed in relation to psychiatric illness and to functional recovery after brain injury.
The term «unconventional virus» refers to virus-like agents that differ from conventional viruses in significant respects–resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained through new techniques in molecular genetics. The work as a whole focuses on the implications of animal data for research on human disorders, such as the possible connection between unconventional viruses and Alzheimer's Disease. The discussions represent the work of specialists from a broad spectrum of fields including virology, neuropathology, and molecular biology.
This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails – a challenge that clinicians will face for many years to come. It is split into three sections: Section 1: A compilation of the major brain lesions typically seen in PD Section 2: Treatment options in PD Section 3: 25 cases designed to test the reader and the practical application of the information supplied in the other sections.
The European Handbook of Neurological Management, published in collaboration with the European Federation of Neurological Societies (EFNS), is a unique book that brings together peer-reviewed guidelines for the treatment and management of neurological disease. For the first time, neurologists can find advice on management aspects of most neurological disorders that is either evidence-based or, where the evidence is inadequate, the consensus guidance of an international European panel of experts. The guidelines fall naturally into sections that cover: Investigation: cerebrospinal fluid analysis, imaging, diagnostic antibodies and skin biopsy Major neurological diseases: stroke, migraine, Parkinson’s disease, dystonia, mild traumatic brain injury, multiple sclerosis and Alzheimer’s disease Neuromuscular diseases: motor neuron disease, inflammatory neuropathy, muscular dystrophy and myasthenia gravis Infections: HIV infection and encephalitis Neurological problems: treatment of neuropathic pain, acute relapses of multiple sclerosis and status epilepticus, to name but a few Sleep disorders: Narcolepsy, other sleep disorders and restless legs syndrome Cognitive rehabilitation. The European Handbook of Neurological Management is a book that any neurologist, without regard to national boundaries, will find a useful aid in the day-to-day management of neurological disease.
The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.
This book is a foundation for further study into childhood headache and serve as a quick, up-to-date reference for the recognition, diagnosis, basic understanding, evaluation and management of headache disorders in children and adolescents. Covers primary headache disorders including migraine Covers secondary headaches, including sinus, and post traumatic headache Provides thoughtful guidelines on behavioural management strategies as well as pharmacologic therapies
Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence