Медицина
Различные книги в жанре МедицинаLead Generation Approaches in Drug Discovery
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
How to Manage Your GP Practice
The business side of running a medical practice may be unappealing but it's crucial How to Manage Your GP Practice is written for GPs and other health professionals running their own practices. It tells you in simple, engaging style what the pitfalls are and how to avoid them. It illustrates the good and bad ways of negotiating through management issues, using case examples and lightening the messages with witty cartoons. Written by a GP with over 10 years' experience editing a leading GP magazine, and an accountant whose firm advises over 2500 GPs, the information here is sound, relevant and up to date. It provides reliable and reassuring information for doctors starting out in their careers as well as those looking to refresh their management skills.
Fundamentals of Anatomy and Physiology for Student Nurses
The mind and the body, when working in harmony, is a fantastic system capable of extraordinary things. With an applied, interactive, and highly visual approach, Fundamentals of Anatomy and Physiology for Student Nurses provides students with an exciting and straightforward understanding of anatomy and physiology, enabling them to deliver high quality care in any setting. This book covers the structure and functions of the human body, with clinical applications throughout. Key features: A clear, straightforward book on anatomy and physiology for all students in nursing and allied health. Fully interactive, with an activity section at the end of each chapter, featuring multiple choice questions, diagram labelling, test your learning questions, crosswords, and 'find out more'. Generous, full colour illustrations throughout Clinical considerations and scenarios throughout showing how the material can be applied to daily practice A companion website where you'll find further exercises, illustrations, and interactive MCQs www.wiley.com/go/peate
Practical Manual of Echocardiography in the Urgent Setting
Practical Manual of Echocardiography in the Urgent Setting covers the essentials of echocardiography in the acute setting, from ultrasound basics to descriptions of all pertinent echocardiographic views to clear stepwise advice on basic calculations and normal/abnormal ranges. This compact new reference: • Provides step-by-step guidance to acquiring the correct views and making the necessary calculations to accurately diagnose cardiac conditions commonly encountered in urgent settings. • Presents information organized by complaint/initial presentation so that readers can work from this first knowledge of the patient through the steps required to pinpoint a diagnosis. • Covers echo basics, from sound wave characteristics/properties to common device settings to basic ultrasound formulas. • Includes diagnostic algorithms fitted to address the differential diagnosis in the most commonly-encountered clinical scenarios. Designed and written by frontline clinicians with extensive experience treating patients, Practical Manual of Echocardiography in the Urgent Setting is the perfect pocket-sized guide for residents in cardiology, emergency medicine, and hospital medicine; trainees in echocardiography; medical students on cardiology or emergency medicine rotations; technicians, nurses, attending physicians – anyone who practices in the urgent setting and who needs reliable guidance on echocardiographic views, data and normal/abnormal ranges to aid rapid diagnosis and decision-making at the point of care.
A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim
The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to pressing global health problems, it is critically important to remain vigilant about moral and ethical safeguards for every patient enrolled in a trial. Those who study this manual will be well aware of how to ensure patient safety along with fiscal responsibility, trial efficiency, and research integrity. —Robert Harrington, Professor of Medicine, Director, Duke Clinical Research Institute, Durham, North Carolina, USA The Duke Clinical Research Institute (DCRI) is one of the world's leading academic clinical research organizations; its mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research. This concise handbook provides a practical «nuts and bolts» approach to the process of conducting clinical trials, identifying methods and techniques that can be replicated at other institutions and medical practices. Designed for investigators, research coordinators, CRO personnel, students, and others who have a desire to learn about clinical trials, this manual begins with an overview of the historical framework of clinical research, and leads the reader through a discussion of safety concerns and resulting regulations. Topics include Good Clinical Practice, informed consent, management of subject safety and data, as well as monitoring and reporting adverse events. Updated to reflect recent regulatory and clinical developments, the manual reviews the conduct of clinical trials research in an increasingly global context. This new edition has been further expanded to include: In-depth information on conducting clinical trials of medical devices and biologics The role and responsibilities of Institutional Review Boards, and Recent developments regarding subject privacy concerns and regulations. Ethical documents such as the Belmont Report and the Declaration of Helsinki are reviewed in relation to all aspects of clinical research, with a discussion of how researchers should apply the principles outlined in these important documents. This graphically appealing and eminently readable manual also provides sample forms and worksheets to facilitate data management and regulatory record retention; these can be modified and adapted for use at investigative sites.
Practical Osseous Surgery in Periodontics and Implant Dentistry
Practical Osseous Surgery in Periodontics and Implant Dentistry is a step-by-step manual that guides readers through osseous surgery procedures for treating periodontal issues as well as for ensuring proper anchorage of dental implants. Dibart and Dibart use hundreds of color photographs and succinct text to illustrate and explain the most recent advances and techniques for creating the ideal bone structure for each patient. This book covers periodontal therapies including resective surgery, and regenerative surgery, as well as implant therapies, including socket perseveration, correcting bony deficiencies, bone grafts, minimally invasive surgical procedures, and the latest technologies such as Piezosurgery. It also devotes chapters to growth-factor enhanced bone grafts, PiezocisionTM, and restoration of the placed implant. Practical Osseous Surgery in Periodontics and Implant Dentistry focuses on clinical applications of surgical procedures, making it an essential tool for both specialists and generalists with an interest in implant dentistry and osseous surgery procedures.
Carbohydrate Recognition. Biological Problems, Methods, and Applications
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Respiratory Medicine, eTextbook. Clinical Cases Uncovered
Rehearse for life in clinical practice with this easy-to-use and unique series, which combines cases drawn from real-life experiences with a refreshing approach to presentations as you would see them in day-to-day situations. Get the most from clinical practice, with Clinical Cases Uncovered This essential title in the Clinical Cases Uncovered series includes many important scenarios in respiratory medicine that feature in real-life clinical practice. Everything is covered, from respiratory arrest and asthma to environmental effects and abnormal chest X-rays. Anatomy, physiology and the relevant pathological background feature in the basic science section, with important advice on the approach to the patient. The self-assessment section at the end is crucial to testing your understanding, giving you the best possible preparation. For further information, visit www.clinicalcasesuncovered.com
Oral Rehabilitation. A Case-Based Approach
This book provides its readers with a structured approach to decision-making and case management in oral rehabilitation. It is built around actual patient cases from simple prosthodontics to complex full-mouth reconstructions, demonstrating a formal process by which a diagnosis and treatment plan is reached. Grounded firmly in evidence-based principles, the book also includes a chapter on literature searching in dentistry, which is critical for acquiring a knowledge-base for informed decisions in clinical treatment. Featuring an approach to prosthodontics and oral rehabilitation that is both instructional and practical, Oral Rehabilitation: A Case-Based Approach will help clinicians to develop the necessary skills to make consistent, evidence-based clinical decisions. KEY FEATURES • Presents a case-based process showing how diagnosis and treatment is achieved • Covers a range of clinical scenarios from simple to complex presentations • Illustrates each case fully, with stages documented by colour photographs • Emphasises inter-disciplinary management in prosthodontics • Accompanied by a website containing illustrative video clips