John Wiley & Sons Limited
Все книги издательства John Wiley & Sons LimitedBlood and Marrow Transplantation Long Term Management
Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT), and accommodation of older and less fit recipients. The development of less toxic pretransplant conditioning regimens, more effective prophylaxis of graft-versus-host disease (GVHD), improved infection control, and other advances in transplant technology have resulted in a rapidly growing number of transplant recipients surviving long-term free of the disease for which they were transplanted. The changes over decades in the transplant recipient population and in the practice of HCT will have almost inevitably altered the composition of the long-term survivor population over time. Apart from an increasingly older transplant recipient cohort, the pattern of transplant indications has shifted from the 1990s when chronic myeloid leukemia made up a significant proportion of allo-HCT indications. Changes in cell source, donor types, conditioning regimens, GVHD prophylaxis, and supportive care have all occurred, with ongoing reductions in both relapse and non-relapse mortality (NRM) have been demonstrated. These patients have increased risks for a variety of late complications, which can cause morbidity and mortality. Most long-term survivors return to the care of their local hematologists/oncologists or primary care physicians, who may not be familiar with specialized monitoring and management of long complications after HCT for this patient population. As HCT survivorship increases, the focus of care has shifted to the identification and treatment of long-term complications that may affect quality of life and long-term morbidity and mortality. Preventive care as well as early detection and treatments are important aspects to reducing morbidity and mortality in long-term survivors after allo-HCT. This second edition, Blood and Marrow Transplantation Long-Term Management: Survivorship after Transplant , provides up-to-date information about diagnosis, screening, treatment, and long-term surveillance of long-term survivors after HCT.
BBQ For Dummies
The complete year-round guide to BBQ and smoking! The BBQing and smoking industry is heating up! No longer reserved for warm weather occasions or backyard gatherings, firing up the grill or smoker is becoming ever-more popular in everyday American cooking. Written by America’s Pit Master and award-winning restaurant owner Carey Bringle of Peg Leg Porker , one of the most famous BBQ spots in Nashville, this book features more than 50 recipes and provides tried-and-true advice on BBQing and smoking all types of meat, seafood, chicken, pork, and veggies. Choose the right wood and get the best smoker or grill Get recipes for marinades, rubs, injections, and sauces Cook up hog, ribs, brisket, and chicken, and more Work with certain cuts of meat If you’re looking for a new guide to classic barbeque and more, look no further.
What's Wrong with NATO and How to Fix it
NATO, the most successful alliance in history, is beset by unresolved tensions and divergent interests that are undermining its cohesion, credibility and capability. In this new book, Mark Webber, James Sperling and Martin Smith explore four key post-Cold War developments that threaten NATO's survival: an overextended geostrategic reach and an unwieldly security policy portfolio; a failure to address capability short-falls and meet defence spending benchmarks; US weariness and European wariness that call NATO into question; and intra-alliance discord over Russia’s place in the European security order and how to deal with Moscow’s destabilization of Georgia and Ukraine. The authors propose in response a range of policy options that could reinvigorate NATO, but conclude with a note of caution. Alliances come and go and most are cast into the dustbin of history. If NATO is to avoid this fate, it must not only address the major problems that trouble it, but also get to grips with future challenges to alliance cohesion and credibility, from Brexit to the emerging contest with China.
