Practical and conceptual, the Responsible Research and Innovation set of books contributes to the clarification of this new requirement for all sciences and technological innovation. It covers the multiple and international responsibilities, by using various philosophical resources, mostly discussing the following topics: ethics, contingency, normative economy, freedom, corporate social responsibility (CSR), participative technological evaluation, sustainable development, geoengineering, the precautionary principle, standards, interdisciplinarity, and climate management. The ethics of efficiency must be considered with regard to the logic of action or to economic, political, legal or scientific systems. This book presents a question on the central theme of responsible research and innovation (RRI), which has an ethical influence on effective logics. The issue is to question the opportunity and modularities of an ethical effective influence on the logics of efficiency of research and innovation. From the distinction of efficiency and effectiveness, lies the problem of efficacy, the ethical accord between the two. Thus appears the possibility of taking effective responsibility with respect to systematic injustices potentially linked to this efficiency. This book proposes categories to understand the ethical implications of research and innovation processes, under the aspect of their efficacy.
Religious Conversion: Religion Scholars Thinking Together explores various issues relating to the nature, methods, and effects of religious conversion in the major world faiths. Presents the results of an innovative ten-year project initiated the World Council of Churches Features contributions from religious scholars and leaders of Buddhist, Christian, Hindu, Jewish, and Muslim traditions Considers myriad issues relating to the nature, methods, and effects of religious conversion in the major world faiths Addresses questions on religious freedom, legal considerations, and the future for religious conversion
An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley's Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biophar- maceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.
This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals. Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.
Building information modelling (BIM) is revolutionising building design and construction. For architects, BIM has the potential to optimise their creativity while reducing risk in the design and construction process, thus giving them a more significant role in the building process. This book demonstrates how innovative firms are using BIM technologies to move design away from the utilitarian problems of construction, engaging them in a stunning new future in the built environment. Whereas recent books about BIM have tended to favour case-study analyses or instruction on the use of specific software, BIM Design highlights how day-to-day design operations are shaped by the increasingly generative and collaborative aspects of these new tools. BIM strategies are described as operations that can enhance design rather than simply make it more efficient. Thus this book focuses on the specific creative uses of information modelling at the operational level, including the creative development of parametric geometries and generative design, the evaluation of environmental performance and the simulation and scheduling of construction/fabrication operations. This book also engages BIM’s pragmatic efficiencies such as the conflict checking of building systems and the creation of bills of quantities for costing; and in so doing it demonstrates how BIM can make such activities collaborative. Throughout, projects are used to illustrate the creative application of BIM at a variety of scales. These buildings showcase work by fi rms executing projects all over the world: SHoP Architects and Construction (New York), Morphosis (Los Angeles), Populous (London), GRO Architects (New York), Reiser + Umemoto (New York), Gensler (Shanghai) and UNStudio (Amsterdam).
Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. • Surveys methods used for preparing arene compounds and their transformations • Connects reactivity and methodology with mechanism • Helps readers apply aromatic reactions in a practical context by designing syntheses • Provides essential information about techniques used to determine reaction mechanisms
The book bridges the gap between existing health physics textbooks and reference material needed by a practicing health physicist as the 21st century progresses. This material necessarily encompasses emerging radiation-generating technologies, advances in existing technology, and applications of existing technology to new areas. The book is written for advanced undergraduate and graduate science and engineering courses. It is also be a useful reference for scientists and engineers.
Theories and practices to assess critical information in a complex adaptive system Organized for readers to follow along easily, The Fitness of Information: Quantitative Assessments of Critical Evidence provides a structured outline of the key challenges in assessing crucial information in a complex adaptive system. Illustrating a variety of computational and explanatory challenges, the book demonstrates principles and practical implications of exploring and assessing the fitness of information in an extensible framework of adaptive landscapes. The book’s first three chapters introduce fundamental principles and practical examples in connection to the nature of aesthetics, mental models, and the subjectivity of evidence. In particular, the underlying question is how these issues can be addressed quantitatively, not only computationally but also explanatorily. The next chapter illustrates how one can reduce the level of complexity in understanding the structure and dynamics of scientific knowledge through the design and use of the CiteSpace system for visualizing and analyzing emerging trends in scientific literature. The following two chapters explain the concepts of structural variation and the fitness of information in a framework that builds on the idea of fitness landscape originally introduced to study population evolution. The final chapter presents a dual-map overlay technique and demonstrates how it supports a variety of analytic tasks for a new type of portfolio analysis. The Fitness of Information: Quantitative Assessments of Critical Evidence also features: In-depth case studies and examples that characterize far-reaching concepts, illustrate underlying principles, and demonstrate profound challenges and complexities at various levels of analytic reasoning Wide-ranging topics that underline the common theme, from the subjectivity of evidence in criminal trials to detecting early signs of critical transitions and mechanisms behind radical patents An extensible and unifying framework for visual analytics by transforming analytic reasoning tasks to the assessment of critical evidence The Fitness of Information: Quantitative Assessments of Critical Evidence is a suitable reference for researchers, analysts, and practitioners who are interested in analyzing evidence and making decisions with incomplete, uncertain, and even conflicting information. The book is also an excellent textbook for upper-undergraduate and graduate-level courses on visual analytics, information visualization, and business analytics and decision support systems.
Discusses the evolution of WHOIS and how policy changes will affect WHOIS’ place in IT today and in the future This book provides a comprehensive overview of WHOIS. The text begins with an introduction to WHOIS and an in-depth coverage of its forty-year history. Afterwards it examines how to use WHOIS and how WHOIS fits in the overall structure of the Domain Name System (DNS). Other technical topics covered include WHOIS query code and WHOIS server details. The book also discusses current policy developments and implementations, reviews critical policy documents, and explains how they will affect the future of the Internet and WHOIS. Additional resources and content updates will be provided through a supplementary website. Includes an appendix with information on current and authoritative WHOIS services around the world Provides illustrations of actual WHOIS records and screenshots of web-based WHOIS query interfaces with instructions for navigating them Explains network dependencies and processes related to WHOIS utilizing flowcharts Contains advanced coding for programmers Visit the book's companion website http://whois.knujon.com for technical and policy documents concerning WHOIS, WHOIS code examples, internet locations for WHOIS databases and more. WHOIS Running the Internet: Protocol, Policy, and Privacy is written primarily for internet developers, policy developers, industry professionals in law enforcement, digital forensic investigators, and intellectual property attorneys. Garth O. Bruen is an Internet policy and security researcher whose work has been published in the Wall Street Journal and the Washington Post. Since 2012 Garth Bruen has served as the North American At-Large Chair to the Internet Corporation of Assigned Names and Numbers (ICANN). In 2003 Bruen created KnujOn.com with his late father, Dr. Robert Bruen, to process and investigate Internet abuse complaints (SPAM) from consumers. Bruen has trained and advised law enforcement at the federal and local levels on malicious use of the Domain Name System in the way it relates to the WHOIS record system. He has presented multiple times to the High Technology Crime Investigation Association (HTCIA) as well as other cybercrime venues including the Anti-Phishing Working Group (APWG) and the National Center for Justice and the Rule of Law at The University of Mississippi School of Law. Bruen also teaches the Fisher College Criminal Justice School in Boston where he develops new approaches to digital crime.
Research into cellulose nanocrystals is currently in an exponential growth phase, with research into potential applications now strengthened by recent advances in nanomanufacturing. The possibility of routine commercial production of these advanced materials is now becoming a reality. Cellulose Nanocrystals: Properties, Production and Applications provides an in-depth overview of the materials science, chemistry and physics of cellulose nanocrystals, and the technical development of advanced materials based on cellulose nanocrystals for industrial and medical applications. Topics covered include: • A comprehensive treatment of the structure, morphology and synthesis of cellulose nanocrystals. • The science and engineering of producing cellulose nanocrystals and the challenges involved in nanomanufacturing on a large industrial scale. • Surface/interface modifications of cellulose nanocrystals for the development of novel biomaterials with attractive structural and functional properties. • The scientific bases for developing cellulose-based nanomaterials with advanced functionalities for industrial/medical applications and consumer products. • Discussions on the (i) reinforcing potential of cellulose nanocrystals in polymer nanocomposites, (ii) utilization of these nanocrystals as efficient templates for developing tunable photonic materials, as well as (iii) applications in sustainable electronics and biomedicine. Cellulose Nanocrystals: Properties, Production and Applications will appeal to audiences in the physical, chemical and biological sciences as well as engineering disciplines. It will be of critical interest to industrialists seeking to develop sustainable new materials for the advanced industrial economies of the 21st century, ranging from adaptive “smart” packaging materials, to new chiral, mesoporous materials for optoelectronics and photonics , to high-performance nanocomposites for structural applications.