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A comprehensive guide to optimizing the lifecycle management of pharmaceutical brands The mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand drugs essential for pharmaceutical companies looking to maximize the value of their products. Demonstrating how different measures can be combined to create winning strategies, Pharmaceutical Lifecycle Management: Making the Most of Each and Every Brand explores this increasingly important field to help readers understand what they can—and must—do to get the most out of their brands. Offering a truly immersive introduction to LCM options for pharmaceuticals, the book incorporates numerous real-life case studies that demonstrate successful and failed lifecycle management initiatives, explaining the key takeaway of each example. Filled with practical information on the process of actually writing and presenting an LCM plan, as well as how to link corporate, portfolio, and individual brand strategies, the book also offers a look ahead to predict which LCM strategies will continue to be effective in the future. While the development of new drugs designed to address unmet patient needs remains the single most important goal of any pharmaceutical company, effective LCM is invaluable for getting the greatest possible value from existing brands. Pharmaceutical Lifecycle Management walks you through the process step by step, making it indispensable reading for pharmaceutical executives and managers, as well as anyone working in the fields of drug research, development, and regulation.
Zizek Now. Current Perspectives in Zizek Studies
Arguably the most prolific and most widely read philosopher of our time, Slavoj Zizek has made indelible interventions into many disciplines of the so-called human sciences that have transformed the terms of discussion in these fields. Although his work has been the subject of many volumes of searching criticism and commentary, there is no assessment to date of the value of his work for the development of these disciplines. Zizek Now brings together distinguished critics to explore the utility and far-ranging implications of Zizek's thought and provide an evaluation of the difference his work makes or promises to make in their chosen fields. As such, the volume offers chapters on quantum physics and Zizek's transcendentalist materialist theory of the subject, Hegel's absolute, materialist Christianity, postcolonial violence, eco-politics, ceremonial acts, and the postcolonial revolutionary subject. Contributors to the volume include Adrian Johnston, Ian Parker, Todd McGowan, Bruno Bosteels, Erik Vogt, Verena Conley, Joshua Ramey, Jamil Khader, and Zizek himself.
American Idol After Iraq. Competing for Hearts and Minds in the Global Media Age
This dazzling little book explores the role of US media in foreign policy, not only at the present moment, but with an eye to the future. Written by a veteran Hollywood film executive and an internationally known columnist in foreign affairs Explains how American movies, TV shows, and pop music provide the images of America to the rest of the world, and the rest of the world to Americans Includes discussions of the cartoons of the Prophet Mohammed Danish daily newspapers, Tibetan monks censored out of Chinese TV news reports only to show up on You Tube, and the Vatican's assault on the Da Vinci Code movie Argues that Hollywood is a key player in the 'deep coalition' required to support a 'smart power' foreign policy and build a global cultural infrastructure that will make the world safe for interdependence
Coaching Skills for Nonprofit Managers and Leaders. Developing People to Achieve Your Mission
The only nonprofit orientation to coaching skills available, Coaching Skills for Nonprofit Leaders will provide nonprofit managers with an understanding of why and how to coach, how to initiate coaching in specific situations, how to make coaching really work, and how to refine coaching for long-term success. Coaching Skills for Nonprofit Leaders offers practical steps for coaching leaders to greatness and complements the academic and theoretical work in nonprofit leadership theory. The book can be used by the coaching novice as a thorough topical overview or by those more experienced with coaching as a quick reference or refresher. Based on the Inquiry Based Coaching? approach, Coaching Skills will strengthen and expand the reader?s ability to drive organization mission, while retaining the intrinsic values of the nonprofit culture and working towards outcomes that create a culture of discipline and accountability and empower others to be even more responsible, accountable, and self-motivated. This book uses accessible language, examples, case studies, key questions, and exercises to help: Promote better relationships Know when to delegate, direct and coach. Balance directive and supportive styles of leadership for productive partnerships Overcome fears and deal head-on with difficult situations and conflict. Use coaching for performance improvement and on-the-job development. Support independent thinking and personal reflection Gain commitment and accountability from others and build teams
Principles of Communications Networks and Systems
Addressing the fundamental technologies and theories associated with designing complex communications systems and networks, Principles of Communications Networks and Systems provides models and analytical methods for evaluating their performance. Including both the physical layer (digital transmission and modulation) and networking topics, the quality of service concepts belonging to the different layers of the protocol stack are interrelated to form a comprehensive picture. The book is designed to present the material in an accessible but rigorous manner. It jointly addresses networking and transmission aspects following a unified approach and using a bottom up style of presentation, starting from requirements on transmission links all the way up to the corresponding quality of service at network and application layers. The focus is on presenting the material in an integrated and systematic fashion so that students will have a clear view of all the principal aspects and of how they interconnect with each other. A comprehensive introduction to communications systems and networks, addressing both network and transmission topics Structured for effective learning, with basic principles and technologies being introduced before more advanced ones are explained Features examples of existing systems and recent standards as well as advanced digital modulation techniques such as CDMA and OFDM Contains tools to help the reader in the design and performance analysis of modern communications systems Provides problems at the end of each chapter, with answers on an accompanying website
Spatial and Spatio-temporal Bayesian Models with R - INLA
Spatial and Spatio-Temporal Bayesian Models with R-INLA provides a much needed, practically oriented & innovative presentation of the combination of Bayesian methodology and spatial statistics. The authors combine an introduction to Bayesian theory and methodology with a focus on the spatial and spatio-temporal models used within the Bayesian framework and a series of practical examples which allow the reader to link the statistical theory presented to real data problems. The numerous examples from the fields of epidemiology, biostatistics and social science all are coded in the R package R-INLA, which has proven to be a valid alternative to the commonly used Markov Chain Monte Carlo simulations
Verbindungen im Stahl- und Verbundbau
Zentrale Themen des Buches sind geschweißte und geschraubte Verbindungen im Stahl- und Verbundbau. Darüber hinaus werden auch andere Verbindungstechniken und Verbindungsmittel behandelt, wie z. B.: Kontakt, Kopfbolzendübel, Setzbolzen, Niete, Augenstäbe, Bolzen, Hammerschrauben, Zuganker, Dübel und Ankerschienen. Auf die Methoden und Vorgehensweisen zur Bemessung und konstruktiven Durchbildung von Verbindungen wird ausführlich eingegangen. Neben den allgemeingültigen Grundlagen werden die Regelungen der DIN 18800 und der Eurocodes behandelt und Erläuterungen zum Verständnis gegeben. Zahlreiche Konstruktions- und Berechnungsbeispiele auf Grundlage der Eurocodes zeigen die konkrete Anwendung und Durchführung der Tragsicherheitsnachweise.
Advanced Mobility and Transport Engineering
Multimodal transport network customers need to be directed during their travels. A travel support tool can be offered by a Multimodal Information System (MIS), which allows them to input their needs and provides them with the appropriate responses to improve their travel conditions. The goal of this book is to design and develop methodologies in order to realize a MIS tool which can ensure permanent multimodal information availability before and during travel, considering passengers’ mobility. The authors propose methods and tools that help transport network customers to formulate their requests when they connect to their favorite information systems through PC, laptop, cell phone, Portable Digital Assistant (PDA), etc. The MIS must automatically identify the websites concerning the customer’s services. These sites can, in fact, represent transport services, cultural services, tourist services, etc. The system should then be able to collect the necessary travel information from these sites in order to construct and propose the most convenient information according to the user’s requests. Contents 1. Agent-oriented Road Traffic Simulation, René Mandiau, Sylvain Piechowiak, Arnaud Doniec and Stéphane Espié. 2. An Agent-based Information System for Searching and Creating Mobility-aiding Services, Slim Hammadi and Hayfa Zgaya. 3. Inter-vehicle Services and Communication, Sylvain Lecomte, Thierry Delot and Mikael Desertot. 4. Modeling and Control of Traffic Flow, Daniel Jolly, Boumediene Kamel and Amar Benasser. 5. Criteria and Methods for Interactive System Evaluation: Application to a Regulation Post in the Transport Domain, Houcine Ezzedine, Abdelwaheb Trabelsi, Chi Dung Tran and Christophe Kolski.
Neural-Based Orthogonal Data Fitting. The EXIN Neural Networks
The presentation of a novel theory in orthogonal regression The literature about neural-based algorithms is often dedicated to principal component analysis (PCA) and considers minor component analysis (MCA) a mere consequence. Breaking the mold, Neural-Based Orthogonal Data Fitting is the first book to start with the MCA problem and arrive at important conclusions about the PCA problem. The book proposes several neural networks, all endowed with a complete theory that not only explains their behavior, but also compares them with the existing neural and traditional algorithms. EXIN neurons, which are of the authors' invention, are introduced, explained, and analyzed. Further, it studies the algorithms as a differential geometry problem, a dynamic problem, a stochastic problem, and a numerical problem. It demonstrates the novel aspects of its main theory, including its applications in computer vision and linear system identification. The book shows both the derivation of the TLS EXIN from the MCA EXIN and the original derivation, as well as: Shows TLS problems and gives a sketch of their history and applications Presents MCA EXIN and compares it with the other existing approaches Introduces the TLS EXIN neuron and the SCG and BFGS acceleration techniques and compares them with TLS GAO Outlines the GeTLS EXIN theory for generalizing and unifying the regression problems Establishes the GeMCA theory, starting with the identification of GeTLS EXIN as a generalization eigenvalue problem In dealing with mathematical and numerical aspects of EXIN neurons, the book is mainly theoretical. All the algorithms, however, have been used in analyzing real-time problems and show accurate solutions. Neural-Based Orthogonal Data Fitting is useful for statisticians, applied mathematics experts, and engineers.
Vascular and Endovascular Surgery at a Glance
Following the popular and accessible at a Glance format, Vascular and Endovascular Surgery at a Glance demystifies the important concepts of vascular disease and vascular surgery. Featuring in-depth details of common vascular topics, to rarer presentations, this is an ideal guide for those interested in a variety of subjects relating to this rapidly expanding area. This is a must-read for any specialist at all levels who has an on-going commitment to vascular disease management and medical education. Vascular and Endovascular Surgery at a Glance: • Comprehensively covers the key concepts and core practical procedures with superb illustrations • Is a brilliant companion to the emerging curriculum for specialist vascular training • Is an excellent source of information and management guidelines for interdisciplinary specialties • Includes a companion website at www.ataglanceseries.com/vascular featuring a wide range of interactive multiple choice questions This title forms a succinct overview of vascular disease management, giving salient points relevant to general surgery examinations, for those requiring an in-depth yet manageable introduction to vascular diseases, and for those entering this prevalent field as a stand-alone specialty.