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This book aims to be a guide to the practice of blood conservation. The first chapter discusses the legal and administrative aspects of bloodless medicine describing the legal principles and practical issues relatd to refusal of transfusion. The second is on balancing the risks and benefits of transfusion includes clinical vignettes of appropriate and inappropriate transfusion. The remainder of the book covers the principles and practice of bloodless medicine, including a chapter on the scientific issues of haemostasis and the investigation of bleeding idsorders. The book concludes with chapters on blood conservation in neonatal and paediatric surgery, the costs associated with blood transfusion and the quest for artifical blood. New chapters will be included to address blood utilization in oncology and geriatric patients.
Office Markets and Public Policy
This is the first book that looks at how offices and office markets in cities have changed over the last 30 years. It analyses the long-term trends and processes within office markets, and the interaction with the spatial economy and the planning of cities. It draws on examples around the world, and looking forward at the future consequences of information communication technologies and the sustainability agenda, it sets out the challenges that now face investors. The traditional business centres of cities are losing their dominance to the brash new centres of the 1980s and 1990s, as the concept of the central business district becomes more diffuse. Edge cities, business space and office parks have entered the vocabulary as offices have also decentralised. The nature and pace of changes to office markets set within evolving spatial structures of cities has had implications for tenants and led to a demand for shorter leases. The consequence is a rethink of the traditional perception of property investment as a secure long term investment, and this is reflected in reduced investment holding periods by financial institutions. Office Markets & Public Policy analyses these processes and policy issues from an international perspective and covers: A descriptive and theoretical base encompassing an historical context, a review of the fundamentals of the demand for and supply of the office market and offices as an investment. Embedded within this section is a perspective on underlying forces particularly the influence of technological change. A synthesis of our understanding of the spatial structure and dynamics of local office markets at the city level. An assessment of the goals and influence of planning policies, and the evaluation of policies designed toward the long term sustainability of cities as services centres. This goes beyond standard real estate and urban economics books by assessing the changing shape of urban office markets within a spatial theoretical and policy context. It will be a useful advanced text for honours and postgraduate students of land economy; land management; property and real estate; urban planning; and urban studies. It will also be of interest to researchers, property professionals, policy-makers and planning practitioners.
A User's Manual to the PMBOK Guide
The must-have manual to understand and use the latest edition of the Fifth Edition The professional standard in the field of project management, A Guide to the Project Management Body of Knowledge (PMBOK® Guide—Fifth Edition) published by the Project Management Institute (PMI®) serves as the ultimate resource for professionals and as a valuable studying and training device for students taking the PMP® Exam. A User's Manual to the PMBOK® Guide takes the next logical step to act as a true user's manual. With an accessible format and easy-to-understand language, it helps to not only distill essential information contained in the PMBOK® Guide—Fifth Edition, but also fills an educational gap by offering instruction on how to apply its various tools and techniques. This edition of the User's Manual: Defines each project management process in the PMBOK® Guide—Fifth Edition, describes the intent, and discusses the individual ITTOs (inputs, tools and techniques, and outputs) Features examples, handy tips, and sample forms to supplement learning Contains a data flow diagram of each process in the PMBOK® Guide—Fifth Edition to show how information is distributed Is updated to provide deeper coverage of stakeholder management and to include new processes for scope, schedule, cost, and stakeholder management The User's Manual enables you to put the PMBOK Guide—Fifth Edition to work on your projects. It will help you implement the processes described in the PMBOK Guide—Fifth Edition and apply the tools and techniques to help make your projects successful. Thorough in coverage and rich in content, it is a worthy companion to augment the important strategies laid out in the PMBOK® Guide—Fifth Edition, and the one book that aspiring or professional project managers should never be without. Fully updated to align with A Guide to the Project Management Body of Knowledge (PMBOK® Guide)–Fifth Edition Describes how to apply tools and techniques for projects and how to create process outputs Presents information by process group Expands upon the PMBOK® Guide with information on the sponsor's role and planning loops Integrates and describes interpersonal skills into the process where they are identified (PMBOK, PMI, PMP and Project Management Professional are registered marks of the Project Management Institute, Inc.)
Practical Pediatric and Adolescent Gynecology
Pediatric and Adolescent Gynecology Edited by Paula J Adams Hillard, MD, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA The gynecologic needs of younger patients are variable and complex Clinicians are often uncomfortable with the gynecologic concerns of young girls and developing women. How can I put the patient at ease? What are the rights of the patient and her parents? How do I ask the questions in a way that allows her to trust me so that I can better understand her medical and social situation? In Pediatric and Adolescent Gynecology, Dr Hillard has designed a new textbook that puts the patient at the center. It follows the patient’s life and her changing needs as she matures. An emphasis on effective, patient-friendly encounters is the prelude to a sensitive clinical approach to intimate, potentially awkward, clinical challenges. Short, practical chapters provide guidance on the issues rather than an academic treatise. This ‘in the office’ guide to effective patient care is informed by evidence-based practice and backed by a wealth of practical features: Algorithms and guidelines to most effective approaches ‘Tips and Tricks’ boxes so you can improve you clinical outcomes ‘Caution’ warning boxes so you can avoid complications ‘Science Revisited’ boxes give a quick reminder of the basic science principles Dr Hillard has assembled an expert group of authors to provide straightforward guidance to caring for and reassuring your younger patients and their parents. If you provide clinical care to girls and young women then Pediatric and Adolescent Gynecology is designed for you. Titles of related interest Contraception Shoupe (ed); ISBN 978-1-4443-3351-0 Sexually Transmitted Diseases Beigi (ed); ISBN: 978-0-470-65835-2 Disorders of Menstruation Marshburn and Hurst (eds); ISBN 978-1-4443-3277-3
High-Throughput Screening Methods in Toxicity Testing
Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's «Toxicity Testing in the 21st Century: A Vision and Strategy» and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.
Stress Corrosion Cracking of Pipelines
Explains why pipeline stress corrosion cracking happens and how it can be prevented Pipelines sit at the heart of the global economy. When they are in good working order, they deliver fuel to meet the ever-growing demand for energy around the world. When they fail due to stress corrosion cracking, they can wreak environmental havoc. This book skillfully explains the fundamental science and engineering of pipeline stress corrosion cracking based on the latest research findings and actual case histories. The author explains how and why pipelines fall prey to stress corrosion cracking and then offers tested and proven strategies for preventing, detecting, and monitoring it in order to prevent pipeline failure. Stress Corrosion Cracking of Pipelines begins with a brief introduction and then explores general principals of stress corrosion cracking, including two detailed case studies of pipeline failure. Next, the author covers: Near-neutral pH stress corrosion cracking of pipelines High pH stress corrosion cracking of pipelines Stress corrosion cracking of pipelines in acidic soil environments Stress corrosion cracking at pipeline welds Stress corrosion cracking of high-strength pipeline steels The final chapter is dedicated to effective management and mitigation of pipeline stress corrosion cracking. Throughout the book, the author develops a number of theoretical models and concepts based on advanced microscopic electrochemical measurements to help readers better understand the occurrence of stress corrosion cracking. By examining all aspects of pipeline stress corrosion cracking—the causes, mechanisms, and management strategies—this book enables engineers to construct better pipelines and then maintain and monitor them to ensure safe, reliable energy supplies for the world.
Ultra-High Performance Liquid Chromatography and Its Applications
Explores both the benefits and limitations of new UHPLC technology High performance liquid chromatography (HPLC) has been widely used in analytical chemistry and biochemistry to separate, identify, and quantify compounds for decades. The science of liquid chromatography, however, was revolutionized a few years ago with the advent of ultra-high performance liquid chromatography (UHPLC), which made it possible for researchers to analyze sample compounds with greater speed, resolution, and sensitivity. Ultra-High Performance Liquid Chromatography and Its Applications enables readers to maximize the performance of UHPLC as well as develop UHPLC methods tailored to their particular research needs. Readers familiar with HPLC methods will learn how to transfer these methods to a UHPLC platform and vice versa. In addition, the book explores a variety of UHPLC applications designed to support research in such fields as pharmaceuticals, food safety, clinical medicine, and environmental science. The book begins with discussions of UHPLC method development and method transfer between HPLC and UHPLC platforms. It then examines practical aspects of UHPLC. Next, the book covers: Coupling UHPLC with mass spectrometry Potential of shell particles in fast liquid chromatography Determination of abused drugs in human biological matrices Analyses of isoflavones and flavonoids Therapeutic protein characterization Analysis of illicit drugs The final chapter of the book explores the use of UHPLC in drug metabolism and pharmacokinetics studies for traditional Chinese medicine. With its frank discussions of UHPLC's benefits and limitations, Ultra-High Performance Liquid Chromatography and Its Applications equips analytical scientists with the skills and knowledge needed to take full advantage of this new separation technology.
The Science of Meat Quality
Meat has been a long sought after source of nutrients in human diets. Its nutrient-dense composition of protein, fats, vitamins and minerals makes it an integral part to healthy and balanced diets. As demand for meat continues to increase globally, a better understanding of efficiently producing quality meat products is becoming increasingly important. The Science of Meat Quality provides comprehensive coverage of meat quality from the biological basis of muscle development to end-product-use topics such as preparation and sensory analysis. The Science of Meat Quality explores the basis of meat quality long before it hits grocery store shelves. The book opens with a look at cellular muscle tissue development, metabolism and physiology. Subsequent chapters look at topics surrounding the development of tenderness, water-holding capacity, lipid oxidation and color in meat products. The final chapters discuss producing a good-tasting end product from preparing meat to preventing food-borne illness. Each chapter contains not only the theory behind that topic, but also detailed lab methodologies for measuring each meat quality trait. The Science of Meat Quality is an essential resource and reference for animal scientists, meat scientists, food scientists, and food industry personnel. Meat has been a long sought after source of nutrients in human diets. Its nutrient-dense composition of protein, fats, vitamins and minerals makes it an integral part to healthy and balanced diets. As demand for meat continues to increase globally, a better understanding of efficiently producing quality meat products is becoming increasingly important. The Science of Meat Quality provides comprehensive coverage of meat quality from the biological basis of muscle development to end-product-use topics such as preparation and sensory analysis. The Science of Meat Quality explores the basis of meat quality long before it hits grocery store shelves. The book opens with a look at cellular muscle tissue development, metabolism and physiology. Subsequent chapters look at topics surrounding the development of tenderness, water-holding capacity, lipid oxidation and color in meat products. The final chapters discuss producing a good-tasting end product from preparing meat to preventing food-borne illness. Each chapter contains not only the theory behind that topic, but also detailed lab methodologies for measuring each meat quality trait. The Science of Meat Quality is an essential resource and reference for animal scientists, meat scientists, food scientists, and food industry personnel.
Guidelines for Managing Process Safety Risks During Organizational Change
CCPS (Center for Chemical Process Safety)
An understanding of organizational change management (OCM) – an often overlooked subject – is essential for successful corporate decision making with little adverse effect on the health and safety of employees or the surrounding community. Addressing the myriad of issues involved, this book helps companies bring their OCM systems to the same degree of maturity as other process safety management systems. Topics include corporate standard for organizational change management, modification of working conditions, personnel turnover, task allocation changes, organizational hierarchy changes, and organizational policy changes.
The Wiley-Blackwell Companion to Inter-Religious Dialogue
This comprehensive volume brings together a distinguished editorial team, including some of the field’s pioneers, to explore the aims, practice, and historical context of interfaith collaboration. Explores in full the background, history, objectives, and discourse between the leaders and practitioners of the world’s major religions Examines relations between religions from around the world, moving well beyond the common focus on Christianity, to also cover over 12 major religions Features a wealth of case studies on contemporary interreligious dialogue Charts a long-term shift away from a competitive rivalry between belief systems, and a change in focus towards the more respectful, cooperative approach reflected in institutions such as the World Council of Churches Includes up-to-date commentary on the growing dialogue of recent years, written by some of the leading figures working in the field of interfaith discourse