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Posttraumatic Stress Disorder: From Neurobiology to Treatment presents a comprehensive look at this key neuropsychiatric disorder. The text examines the neurobiological basis of post-traumatic stress and how our understanding of the basic elements of the disease have informed and been translated into new and existing treatment options. The book begins with a section on animal models in posttraumatic stress disorder research, which has served as the basis of much of our neurobiological information. Chapters then delve into applications of the clinical neuroscience of posttraumatic stress disorder. The final part of the books explores treatments and how our basic and clinical research is now being converted into treatment. Taking a unique basic science to translational intervention approach, Posttraumatic Stress Disorder: From Neurobiology to Treatment is an invaluable resource for researchers, students and clinicians dealing with this complex disorder.
Indole Ring Synthesis. From Natural Products to Drug Discovery
Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade – highlighted by the power of transition metal catalysis – this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Bone and Joint Infections. From Microbiology to Diagnostics and Treatment
Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.
Human Biological Aging. From Macromolecules to Organ Systems
Comprehension of the theories of aging requires rudimentary knowledge of oxidation and reduction reactions, protein function, cell organelles, mitosis, acquired immunity, and evolution, among other basic biological concepts. Without these fundamentals, students of biological aging struggle to learn the essentials of biological aging and how to appreciate the research advances in the field. Human Biological Aging: From Macromolecules To Organ-Systems is an introduction to human aging from the level of macromolecules to organ systems. Age changes in proteins, DNA, polysaccharides and lipids are discussed relative to known age-related alterations in structure and function produced by free radicals and oxidants. At the cellular level, age-dependent mechanisms that diminish organelle function are described. Cellular phenomena of replicative senescence apoptosis, autophagy and neuroplasticity are detailed as to their contribution to compromised cellular functions. Authored by a leader in the field, Human Biological Aging: From Macromolecules To Organ-Systems is an invaluable introduction for those studying human aging.
Signal Integrity. From High Speed to Radiofrequency Applications
This book presents the necessary concepts for the design and testing of radiofrequency and high-speed circuits. Signal and propagation theory is presented for the various circuit levels, from the chip to the PCB. The co-existence of high-speed wideband signals of radiofrequency signals and supply circuits is developed in order to provide design rules for engineers and Masters-level students. The subjects covered include: interconnections and signal integrity; spectral analysis techniques for high-speed signals; design techniques for signal integrity; the transmission-line concept; methods for temporal analysis and techniques for frequency domain analysis for connectics.
Environmental Health. From Global to Local
The bestselling environmental health text, with all new coverage of key topics Environmental Health: From Global to Local is a comprehensive introduction to the subject, and a contemporary, authoritative text for students of public health, environmental health, preventive medicine, community health, and environmental studies. Edited by the former director of the CDC's National Center for Environmental Health and current dean of the School of Public Health at the University of Washington, this book provides a multi-faceted view of the topic, and how it affects different regions, populations, and professions. In addition to traditional environmental health topics—air, water, chemical toxins, radiation, pest control—it offers remarkably broad, cross-cutting coverage, including such topics as building design, urban and regional planning, energy, transportation, disaster preparedness and response, climate change, and environmental psychology. This new third edition maintains its strong grounding in evidence, and has been revised for greater readability, with new coverage of ecology, sustainability, and vulnerable populations, with integrated coverage of policy issues, and with a more global focus. Environmental health is a critically important topic, and it reaches into fields as diverse as communications, technology, regulatory policy, medicine, and law. This book is a well-rounded guide that addresses the field's most pressing concerns, with a practical bent that takes the material beyond theory. Explore the cross-discipline manifestations of environmental health Understand the global ramifications of population and climate change Learn how environmental issues affect health and well-being closer to home Discover how different fields incorporate environmental health perspectives The first law of ecology reminds is that 'everything is connected to everything else.' Each piece of the system affects the whole, and the whole must sustain us all for the long term. Environmental Health lays out the facts, makes the connections, and demonstrates the importance of these crucial issues to human health and well-being, both on a global scale, and in our homes, workplaces, and neighborhoods.
Environmental Microbiology. From Genomes to Biogeochemistry
New and expanded for its second edition, Environmental Microbiology: From Genomes to Biogeochemistry¸ Second Edition, is a timely update to a classic text filled with ideas, connections, and concepts that advance an in-depth understanding of this growing segment of microbiology. Core principles are highlighted with an emphasis on the logic of the science and new methods-driven discoveries. Numerous up-to-date examples and applications boxes provide tangible reinforcement of material covered. Study questions at the end of each chapter require students to utilize analytical and quantitative approaches, to define and defend arguments, and to apply microbiological paradigms to their personal interests. Essay assignments and related readings stimulate student inquiry and serve as focal points for teachers to launch classroom discussions. A companion website with downloadable artwork and answers to study questions is also available. Environmental Microbiology: From Genomes to Biogeochemistry, Second Edition, offers a coherent and comprehensive treatment of this dynamic, emerging field, building bridges between basic biology, evolution, genomics, ecology, biotechnology, climate change, and the environmental sciences.
Human Exposure to Electromagnetic Fields. From Extremely Low Frequency (ELF) to Radiofrequency
Everyone, whether they like it or not, is exposed to electromagnetic fields, most of the time, at very low levels. In this case, they are inconsequential, but they can cause adverse health effects when they become intense enough. This topic is complex and sensitive. Covering frequencies from 0 Hz to 300 GHz, Human Exposure to Electromagnetic Fields provides an overview of this vast topic. After a reminder of the concepts of electromagnetic fields, the author presents some examples of sources of radiation in daily life and in the industrial or medical sectors. The biophysical and biological effects of these fields on the human body are detailed and the exposure limits are recalled. The exposure assessment and the implementation of the appropriate regulation within companies are also covered. Technically and practically, this book is aimed at people with a scientific background, risk prevention actors, health physicians, especially occupational doctors, and equipment designers.
Health Program Management. From Development Through Evaluation
Learn how to effectively plan, implement, and evaluate health programs Health Program Management: From Development Through Evaluation, Second Edition is a practical and useful introduction to the management of health programs. While providing an overview of the current best practices in management, the textbook goes beyond simple management techniques, teaching students how to develop, lead, and evaluate their programs to ensure quality outcomes. The focus is on the three core management concepts of strategy, design, and leadership, but time is also devoted to describing facilitative management activities integral to successful programs. Students will learn techniques for communication, decision-making, quality assurance, marketing, and program evaluation within the structure of the book's program management model. Logically organized with a separate chapter for each activity, this resource provides a thorough, systematic overview of the effective development, implementation, and evaluation of health programs. Health Program Management: From Development Through Evaluation, Second Edition provides a comprehensive approach to management throughout all stages of a health program. Learn to develop a strategy that steers the program toward specific goals Discover how to design, market, and lead an effective health program Become familiar with the manager's role in a quality health program Evaluate potential and existing programs for performance and capability Students and aspiring managers and leaders preparing themselves for the challenges of managing health programs will find the information and techniques to develop the skills they need in Health Program Management: From Development Through Evaluation, Second Edition.
Radio-Frequency Human Exposure Assessment. From Deterministic to Stochastic Methods
Nowadays approximately 6 billion people use a mobile phone and they now take a central position within our daily lives. The 1990s saw a tremendous increase in the use of wireless systems and the democratization of this means of communication. To allow the communication of millions of phones, computers and, more recently, tablets to be connected, millions of access points and base station antennas have been extensively deployed. Small cells and the Internet of Things with the billions of connected objects will reinforce this trend. This growing use of wireless communications has been accompanied by a perception of risk to the public from exposure to radio frequency (RF) electromagnetic field (EMF). To address this concern, biomedical research has been conducted. It has also been important to develop and improve dosimetry methods and protocols that could be used to evaluate EMF exposure and check compliance with health limits. To achieve this, much effort has was made in the 1990s and 2000s. Experimental and numerical methods, including statistical methods, have been developed. This book provides an overview and description of the basic and advanced methods that have been developed for human RF exposure assessment. It covers experimental, numerical, deterministic and stochastic methods.