A hands-on book which begins by setting the context;– defining 'fermentation' and the possible uses of fermenters, and setting the scope for the book. It then proceeds in a methodical manner to cover the equipment for research scale fermentation labs, the different types of fermenters available, their uses and modes of operation. Once the lab is equipped, the issues of fermentation media, preservation strains and strain improvement strategies are documented, along with the use of mathematical modelling as a method for prediction and control. Broader questions such as scale-up and scale down, process monitoring and data logging and acquisition are discussed before separate chapters on animal cell culture systems and plant cell culture systems. The final chapter documents the way forward for fermenters and how they can be used for non-manufacturing purposes. A glossary of terms at the back of the book (along with a subject index) will prove invaluable for quick reference.Edited by academic consultants who have years of experience in fermentation technology, each chapter is authored by experts from both industry and academia. Industry authors come from GSK (UK), DSM (Netherlands), Eli Lilly (USA) and Broadley James (UK-USA).
With its coverage of Food and Drug Administration regulations, international regulations, good manufacturing practices, and process analytical technology, this handbook offers complete coverage of the regulations and quality control issues that govern pharmaceutical manufacturing. In addition, the book discusses quality assurance and validation, drug stability, and contamination control, all key aspects of pharmaceutical manufacturing that are heavily influenced by regulatory guidelines. The team of expert authors offer you advice based on their own firsthand experience in all phases of pharmaceutical manufacturing.
The first book dedicated to this new and powerful computational method begins with a comprehensive description of MCTDH and its theoretical background. There then follows a discussion of recent extensions of MCTDH, such as the treatment of identical particles, leading to the MCTDHF and MCTDHB methods for fermions and bosons. The third section presents a wide spectrum of very different applications to reflect the large diversity of problems that can be tackled by MCTDH. The result is handbook and ready reference for theoretical chemists, physicists, chemists, graduate students, lecturers and software producers.
In this topical volume, the authors provide in-depth coverage of the vital relationship between electrochemistry and the morphology of thin films and surfaces. Clearly divided into four major sections, the book covers nanoscale dielectric films for electronic devices, superconformal film growth, electrocatalytic properties of transition metal macrocycles, and the use of synchrotron techniques in electrochemistry. All the chapters offer a concise introduction to the relevant topic, as well as supplying numerous references for easy access to further reading and the original literature. The result is must-have reading for electrochemists, physical and surface chemists and physicists, as well as materials scientists and engineers active in the field of spectroscopic methods in electrochemistry.
This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting target compounds and natural compounds with remarkable physiological properties. Mechanistic discussions and retrosynthetic analyses are included. More than 1000 up-to-date references help the reader to pursue the topics highlighted here. This book gives both the active researcher and the advanced student insight into the competitive atmosphere, creativity, and resourcefulness so characteristic of organic synthesis today.
Leading experts from all over the world present an overview of the use of enzymes in industry for: – the production of bulk products, such as glucose, or fructose – food processing and food analysis – laundry and automatic dishwashing detergents – the textile, pulp and paper and animal feed industries – clinical diagnosis and therapy – genetic engineering. The book also covers identification methods of new enzymes and the optimization of known ones, as well as the regulatory aspects for their use in industrial applications. Up to date and wide in scope, this is a chance for non-specialists to acquaint themselves with this rapidly growing field. '…The quality…is so great that there is no hesitation in recommending it as ideal reading for any student requiring an introduction to enzymes. …Enzymes in Industry – should command a place in any library, industrial or academic, where it will be frequently used.' The Genetic Engineer and Biotechnologist 'Enzymes in Industry' is an excellent introduction into the field of applied enzymology for the reader who is not familiar with the subject. … offers a broad overview of the use of enzymes in industrial applications. It is up-to-date and remarkable easy to read, despite the fact that almost 50 different authors contributed. The scientist involved in enzyme work should have this book in his or her library. But it will also be of great value to the marketing expert interested in the present use of enzymes and their future in food and nonfood applications.' Angewandte Chemie 'This book should be available to all of those working with, or aspiring to work with, enzymes. In particular academics should use this volume as a source book to ensure that their 'new' projects will not 'reinvent the wheel'.' Journal of Chemical Technology and Biotechnology
This new edition of the best-selling handbook gives a complete and concise description of the latest knowledge on nuclear and radiochemistry as well as their applications in the various fields of science. It is based on over 40 years experience in teaching courses and research. The book is aimed at all researchers seeking sound knowledge about the properties of matter, whether chemists, physicists, medical doctors, mineralogists or biologists. All of them will find this a valuable source of information. Research in radiochemistry includes: Study of radioactive matter in nature, investigation of radioactive transmutations, chemistry of radioelements etc. Applications include: Radionuclides in geo- and cosmochemistry, dating by nuclear methods, radioanalysis, Mossbauer spectroscopy and related methods, behavior of natural and man-made radionuclides in the environment, dosimetry and radiation protection. All the subjects are presented clearly and comprehensibly, and in a logical sequence, avoiding detailed derivations of equations. The relevant information is compiled in tables and the recent edition of the multi-colored Karlsruhe 'Chart of the Nuclides' has also been included. Clearly a standard work by an author with extensive experience in research and teaching.
Template-controlled reactions allow the synthesis of complex molecules which would hardly be achievable through classical methods. This handbook offers authoratative information on how noncovalent and covalent templates can be effectively applied to control reaction rates as well as regio- and stereoselectivity. From the concepts of template control such as molecular imprinting, self-replication, and reversible tether-directed remote functionalization, the reader is led to template-based ring-closing reactions, oligomerizations, and multiple functionalizations and their application in the synthesis of supramolecular scaffolds and natural products. The editors and authors (J. F. Stoddart, G. Wulf, D. Lynn, R. Breslow. F. Diederich, just to name a few ) , all internationally recognized experts in their area, succeeded in presenting the manifold aspects of template-controlled synthesis in a didactic way, making this methodology accessible to a broad readership of organic synthetic chemists. Well-selected, reliable key experimental protocols and an up-to-date reference list underline the practical approach of this valuable handbook. Being the first book of its kind, it will serve as a pacemaker and stimulate future research.
This handbook gives a complete and concise description of the up-to-date knowledge of nuclear and radiochemsitry and applications in the various fields of science. I is based on teaching courses and on research for over 40 years. The book is addressed to any researcher whishing sound knowledge about the properties of matter, be it a chemist, a physicist, a medical doctor, a mineralogist or a biologist. They will all find it a valuable source of information about the principles and applications of nuclear and radiochemistry. Research in radiochemistry includes: Study of radioactice matter in nature, investigation of radioactive transmutations by chemical methods, chemistry of radioelements etc. Applications include: Radionuclides in geo- and cosmochemistry, dating by nuclear methods, radioanalysis, Mossbaur spectroscopy and related methods, behaviour of natural and man-made radionuclides in the environment, dosimetry and radiation protection. All subjects are presented clearly and comprehensibly, and in logical sequence. Detailed derivations of equations are avoided and relevant information is compiled in tables. The recent edition of the multi-coloured Karlsruhe 'Chart of the Nuclides' is included. Clearly a standard work by an author with extensive experience in research and teaching.
An integrated approach to the molecular theory of reaction mechanism in heterogeneous catalysis, largely based on the knowledge among the growing theoretical catalysis community over the past half century, and covering all major catalytic systems. The authors develop a general conceptual framework, including in-depth comparisons with enzyme catalysis, biomineralisation, organometallic and coordination chemistry. A chapter dedicated to molecular electrocatalysis addresses the molecular description of reactions at the liquid-solid interphase, while studies range from a quantum-chemical treatment of individual molecular states to dynamic Monte-Carlo simulations, including the full flexibility of the many-particle systems. Complexity in catalysis is explained in chapters on self-organization and self-assembly of catalysts, and other sections are devoted to evolutionary, combinatorial techniques as well as artificial chemistry.