Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years – suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists – Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension – makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area. The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs Immune Dysfunction Leading to Heart Disease: Induction by Pathogens Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.
Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand: • how cardiovascular genetics may remodel the way cardiovascular medicine is practiced • what material has immediate relevance to the practicing clinician • how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: • cardiovascular single gene disorders • cardiovascular polygenic disorders • therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
Rupture of an abdominal aortic aneurysm is one of the leading causes of death. The risk of rupture has been a controversial topic for years and only recently have population-based studies provided better evidence for clinical management. This book includes material by an internationally renowned group of authorities directed by a prominent vascular surgeon at Mayo Clinic. The contents represent a well-balanced clinical endovascular approach to the exciting area of vascular medicine and surgery. “We are living in a period of exciting transformation. The message for anyone interested in the treatment of vascular disease is to embrace the new endovascular techniques – learn them and improve them. This is the beginning of a new era.” A. G. Hakaim
Psychological Well-being and Acquired Communication Impairments is an essential resource for all health professionals working with this complex client group. It offers a unique multi-disciplinary approach to the subject, looking at the evidence base as well as clinical practice. The book covers both the assessment of people with acquired communication impairments as well as reviewing the available interventional approaches. Chapters cover such key topics as approaches to the assessment of anxiety and depression, the impact of brain injury, the role of an assessment of mood and the role of self esteem.
Now in its second edition, this is the only book on occupational therapy in oncology and palliative care. It has been thoroughly updated, contains new chapters, and like the first edition will appeal to a range of allied health professionals working with patients with a life-threatening illness. The book explores the nature of cancer and challenges faced by occupational therapists in oncology and palliative care. It discusses the range of occupational therapy intervention in symptom control, anxiety management and relaxation, and the management of breathlessness and fatigue. The book is produced in an evidence-based, practical, workbook format with case studies. New chapters on creativity as a psychodynamic approach; outcome measures in occupational therapy in oncology and palliative care; HIV-related cancers and palliative care.
While this book is based primarily on experiences of occupational therapy practice education in South Africa, it aims to have international appeal as key principles of practice and service learning are drawn from the differing scenarios covered. Based on qualitative research, some of the book’s chapters describe issues faced by students in complex practice situations and highlight educational strategies for promoting socially responsive professional development. They show how students engage with the personal and professional challenges of working in a multicultural society and how situated learning can enhance their resourcefulness in meeting the needs of individuals, groups and communities. The book is divided into three sections: The first, on the practice education agenda, establishes the academic rationale for various forms of practice learning within an occupational therapy curriculum. The second section examines the learning opportunities offered by different practice contexts and highlights mechanisms for developing the professional identity of students. The final section, on enhancing potential, reviews mechanisms that may be used for supporting students in the field, and ends with a look at the future of practice education and how it might develop in response to social and international drivers.
It has been nearly a decade since the first edition of the Handbook for the New Health Care Manager was published. During that time, dramatic changes have taken place in the health care industry and particularly in health care management. Written as a hands-on guide for both novice and seasoned managers, the Handbook for the New Health Care Manager, Second Edition offers a wealth of practical strategies, procedures, and methods that are designed to meet the myriad challenges of today's health care marketplace. This thoroughly revised and updated edition features new information on numerous topics.
Eric Engel and Stylianos Antonarakis have written the most authoritative and vital reference on molecular and clinical aspects of uniparental disomy (UPD) and genomic imprinting to date. Genomic Imprinting and Uniparental Disomy in Medicine features comprehensive overviews of a multitude of genetic disorders linked to UPD, with a strong emphasis on clinical consequences. This book will provide readers with the tools necessary to identify and treat diseases associated with nontraditional chromosomal inheritance. Genomic Imprinting and Uniparental Disomy in Medicine features handy tables summarizing clinical phenotypes and chromosomal involvement in UPD, as well as clear illustrations on imprinting mechanisms and diagnostic testing. This authoritative, completely up-to-date practical reference will be useful for any clinical geneticist, genetic counselor, physician, or researcher encountering patients with such disorders or studying complex disease mechanisms.
This is a systematic review on how innovations in health service practice and organisation can be disseminated and implemented. This is an academic text, originally commissioned by the Department of Health from University College London and University of Surrey, using a variety of research methods. The results of the review are discussed in detail in separate chapters covering particular innovations and the relevant contexts. The book is intended as a resource for health care researchers and academics.
Choice and equity of access to primary and secondary health care services is a priority within all aspects of the NHS, however it must be recognised that for some people access to health care can pose difficulties. For various reasons people with learning disabilities can present a range of challenges for the people around them, during times of ill health any difficulties will become ever more apparent. For the health professional working in mainstream primary and secondary care settings, these challenges can be difficult to overcome when attempting to identify health needs and deliver holistic care that is responsive to their individual needs. Health Care Provision and People with Learning Disabilities – A Guide for Health Professionals provides clear information that will assist mainstream health care providers in gaining greater understanding of people with learning disabilities and managing their health needs. Each chapter gives the reader information and guidance on dealing with a variety of situations found in health care settings. Examples of good practice are explained using case examples and experiences of people with learning disabilities and their carers. The book describes what is expected from the various health care teams and offers solutions to potential challenges and barriers they may be faced with. It includes information regarding specialist support services that can offer assistance to the individual and to the mainstream staff teams, while ideas are also offered on how to present information in a format people who have communication difficulties can understand. The evidence base for Health Care Provision and People with Learning Disabilities – A Guide for Health Professionals has been drawn from extensive research, personal experience, policy guidance, as well as some of the current legislation that is applicable to this diverse group of people. The information shared will prove useful for those working in health settings as well as those undertaking studies in health care.