The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach
Seit dem Erscheinen der ersten Auflage 1994 ist das Lehrbuch «Hämatologie» nicht mehr zu stoppen. Die vorliegende neue, stark überarbeitete und aktualisierte Auflage integriert den neuesten Stand der MTA-Ausbildung. Das Buch orientiert sich thematisch am Lehrinhaltskatalog des Deutschen Verbands Technischer Assistentinnen und Assistenten in der Medizin (dvta). Didaktisch ausgeklügelt ist der Band eine unerlässliche Hilfe in der Ausbildung. Drei Jahre dauert die Ausbildung zur/zum MTA. Es sind drei lernintensive Jahre mit einem anspruchsvollen Mix aus Theorie und Praxis. «Hämatologie» ist das bewährte Lehrbuch, das nun schon einige Generationen von MTA-Auszubildenden begleitet hat. Das Buch gliedert sich in einen theoretischen und einen praktischen Teil. Ersterer behandelt die Grundlagen der Hämatologie und ihrer Krankheitsbilder. Der praktische Teil vermittelt die in der hämatologischen Diagnostik und Therapie verwendeten Techniken. Es gibt zahlreiche Handlungsanleitungen für die tägliche Arbeit. Daneben wird kompetent in Physiologie, Pathophysiologie und Labordiagnostik eingeführt. Der übersichtliche Aufbau sowie etliche erläuternde Tabellen und Abbildungen erleichtern das Verständnis. Und die überzeugende Stoffvermittlung macht vor allem eines deutlich: Die Autoren bringen jahrelange Erfahrung aus der MTA-Ausbildung mit. Dabei trägt die neue Auflage den umfangreichen Fortschritten Rechnung, die insbesondere in der molekularbiologischen Diagnostik erreicht wurden.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
This book addresses the reality of delivering gynaecological care in the 21st century, and looks at the developments that are currently taking place in the field. It provides an overview of some common gynaecological problems and looks at new services and different ways of delivering care. It also shows how gynaecological services are developing in response to women's needs. Above all the book is not medically orientated but shows how nurses and professionals allied to medicine are making a difference. * Covers the latest developments in the gynaecological field * Written soecifically from a nursing and allied health professionals perspective
First Edition – Winner of 2004 BMA Medical Book Competition in Gastroenterology A state-of-the-art reference guide covering all aspects of the performance, technical and clinical background to colonoscopy The second edition of this prize winning book is written by some of the world’s foremost experts in the field of colonoscopy and colonic imaging. Every chapter has been updated and 5 new chapters have been added to include the latest information and advances in the field of colonoscopy: Capsule Colonoscopy Narrow Band Imaging Confocal Endomicroscopy Endoscopic Submucosal Dissection in the Colon New Colonoscopes and Assist Devices Drawing on the vast experience of the authors it covers every area of medicine that impacts on colonoscopy, including virtual colonography, pathology, techniques for pediatric and adult procedures, and legal aspects concerning colonoscopy. The book is focused on patient care, and provides explanations on how to perform the procedure effectively and make the best outcome for your patients. It serves as a detailed manual of procedures, extensively illustrated with diagrams and photographs and there is an accompanying DVD with multiple demonstrations of technique. This is an invaluable compendium on all aspects of colonoscopy, suitable for use by every grade of practitioner world-wide and an essential reference book for allestablishments with an endoscopy facility.
Diabetes is one of the leading causes of morbidity and mortality worldwide. Major complications include nephropathy, neuropathy, retinopathy and heart disease, which affect thousands of diabetics every year. The prevention and treatment of such complications encompass pharmacological, surgical and educational approaches, all of which need to be coordinated for optimal management of people with diabetes. This user-friendly new edition of Diabetes – Chronic Complications (previously called Diabetic Complications) has been completely revised and updated to reflect the rapid developments currently taking place in the field. Each chapter describes the epidemiology, aetiology and management of a particular complication and discusses the organisation and delivery of care. Includes all the major chronic complications of diabetes Presents a practical approach to the treatment of diabetes complications Written by world’s leading experts in the field Features algorithms for screening and treatment of diabetes complications
Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis. Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas – providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine. The most comprehensive book on pheochromocytoma Provides cutting edge science and clinical guidance Written by the leading names in the field Authors present their recently developed novel biochemical test for the diagnosis of Pheochromocytoma
This comprehensive textbook addresses one of the major public health concerns of our era – obesity. Clearly and simply, Obesity: science to practice provides a balanced, coherent account of obesity: how to define and measure it, its epidemiology, the physiological basis, associated diseases, how to assess, manage and treat it, and also strategies for prevention. The book is generously illustrated, including graphs and flow charts for easy reference. The chapters cite key references so that interested readers may pursue a given topic in more detail. Well presented and thoroughly edited by one of the leading experts in the field, this is the textbook of choice for anyone working in obesity.
Infection: Microbiology and Management provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management, epidemiology and the control of infectious conditions as they occur both in the hospital and community setting. With a concise, systems-based approach, the third edition has been revised and restructured and now covers wider epidemiological and public concerns. Key feature boxes, self assessment and case studies assist learning in each chapter. Designed to be used either as a basic learning text, or as a practical textbook in the clinical setting, Infection: Microbiology and Management, previously titled Infectious Disease, will continue to appeal to students at all stages of their career, candidates for higher examinations, the general physician and surgeon, epidemiologists and experts in public health.