This is a major new work dedicated to the increasingly prominent area of adult orthodontics. Written by renowned contributors from the orthodontic community and beyond, and compiled by a world-class editor, it provides an authoritative resource on the subject, marrying together clinical guidance with a thorough evaluation of the evidence base. The opening chapters provide the context for adult orthodontics, including patient demographics and aetiology, and the book goes on to detail treatment planning considerations, including patient case profiles, suggesting initial outcomes and longer term expectations. Interdisciplinary and multidisciplinary approaches are discussed, including the links between adult orthodontics and periodontics, prosthetics and temporomandibular disorders. The book is accompanied by a website containing further examples of case studies and a wealth of clinical images. Set to become the gold standard resource on the subject, this book will be invaluable to all those providing orthodontic treatment to adults and those dealing with orthodontics as part of the inter-disciplinary management of the adult dentition. KEY FEATURES • A major new work on an expanding area of orthodontic treatment • Covers patient demographics, aetiology, treatment planning and maintenance issues • Includes case studies, suggesting realistic and optimal short and long term outcomes • Highly illustrated with full colour clinical photos • Accompanied by a website with further material: www.wiley.com/go/melsen
With the development of new instruments and the refining of new techniques, flexible bronchoscopy has become one of the most frequently performed invasive procedures in pulmonary medicine. This new edition of Flexible Bronchoscopy is an essential addition to the bronchoscopist's bookshelf. It highlights possible complications, contra-indications and precautions. In addition it addresses all current techniques and future technologies in interventional bronchoscopy. For ease of use Flexible Bronchoscopy is divided into four major sections: Fundamentals of Bronchoscopy Diagnostic Bronchoscopy Therapeutic Bronchoscopy Special Considerations Flexible Bronchoscopyis an ideal training manual for all respiratory and pulmonary physicians, as well as trainees and residents working in the field of respiratory medicine, who need to develop the skill of interventional bronchoscopy.
The 80 rules you need to prepare for action in a medical disaster Here are 80 disaster management rules to reflect on, remember and follow in the immediate aftermath of an incident involving mass casualties. Each rule is a single-page long, providing the essential information to inform the most common critical decisions you will have to make in either a civilian or military environment. Written by clinicians with deep clinical and operational experience, these rules are concise evidence-based guidelines for all medical personnel dealing with disasters at the scene or in hospital. Based on the Major Incident Medical Management and Support system widely adopted in the UK, mainland Europe, Australasia and NATO, they are both authoritative and effective.
At over 600 pages, with more than 400 illustrations and photographs this text spans everything from embryology to the emotional trauma women undergo when their cervix is removed at hysterectomy. This is also the most up-to-date text in the field – The editors have referenced work to 2006(and will continue to until the text goes to press), whilst still including all the classic research material and images where appropriate. Essential for gynecologists, oncologists, basic scientists especially those involved in HPV (viral)research, GPs, nurses, colposcopy prctitioners, and sexual transmitted disease doctors The only definitive major clinical reference book published on the cervix for thirty years Including the most up-to-date research on HPV including up-to-date vaccine trial data Highly illustrated in colour including many surgical procedures Spanning the entire field from embryology to cancer to emotional trauma International editorship, with leading names in the field Cervical cancer is the second biggest cause of female cancer mortality worldwide and therefore relevant to the developing and developed world Specific chapters related to management of cervical cancer in the developing world Summaries of recommendations by international bodies including the IARC conference (Lyon 2004), dealing with cervical cancer diagnosis and treatment The Editors, Jordan and Singer, are the co-founders of the British Society for Colposcopy and Cervical Pathology
Dr. Shenasa and his internationally renowned team of editors and contributors reflect all the breakthroughs that have been made in interventional electrophysiology and imaging technologies in recent years in this thoroughly updated guide to cardiac mapping. This third edition focuses on new developments in the field, such as mapping of complex arrhythmias, stereotaxis, and image integration. This useful resource for basic and clinical electrophysiologists illuminates the path to better and safer mapping. A unique feature of this edition is the inclusion of a DVD, which illustrates real-time data from actual cases.
This best selling text has been completely revised and refreshed in the fourth edition. The authors aim to enthuse family doctors (for whom they are primarily writing) to enjoy the challenge of diagnosing and treating skin conditions. Clinical Dermatology contains over 500 high quality pictures and diagrams matched with many colourful phrases to illustrate and entertain as it teaches. It has established a reputation as a ‘way of learning’ and as a cogent overview of the subject for the aspiring specialist. Readers are guided through the maze that too often lies between the presenting skin complaint and its final diagnosis and treatment. The authors have created an easily read text with enough detail to clarify the subject but not enough to obscure it. This fourth edition contains new chapters on racially pigmented skin, dermatology of different age groups and cosmetic dermatology. Relevant internet sites are now clearly highlighted at the end of each chapter and the comprehensive formulary has been updated.
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
A practical approach to the recognition and management of all aspects of migraine Migraine, characterized by periodic bursts of severe debilitating headache, is increasingly recognized as being not only a disease in its own right, but as a disorder that co-occurs with other disorders. Comorbidity in Migraine presents a clinically-oriented, comprehensive treatment approach to migraine. The international collection of authors cover: Migraine and Psychiatric Disorders Migraine and Vascular disorders Migraine and Epilepsy Migraine and other Pain Disorders Migraine and Medication Overuse Case vignettes and management algorithms enhance the clinical utility of the book.Comorbidity in Migraine enhances your ability to treat your migraine patients effectively to improve their quality of life. Titles of Related Interest Pediatric Headaches in Clinical Practice Hershey, Powers, Winner, Kabbouche (eds); ISBN 978-0-470-51273-9 Handbook of Epilepsy Treatment, 3e Shorvon; ISBN 978-1-4051-9818-9 Neurology: A Queen Square Textbook Clarke, Howard, Rossor, Shorvon (eds); ISBN 978-1-4051-3443-9