Pancreatic Tumors. Группа авторов

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      Pancreatic Tumors

      Monographs in Clinical Cytology

      Vol. 26

      Series Editor

      Philippe Vielh Paris

      Pancreatic Tumors

      Volume Editors

      Barbara A. Centeno Tampa, FL

      Jasreman Dhillon Tampa, FL

      107 figures, 100 in color, and 23 tables, 2020

      Monographs in Clinical Cytology

      Founded 1965 by George L. Wied, Chicago, IL

      _______________________

      Prof. Barbara A. Centeno

      Department of Pathology

      Moffitt Cancer Center

      12902 USF Magnolia Drive

      Tampa, FL 33612 (USA)

      [email protected]

      _______________________

      Dr. Jasreman Dhillon

      Associate Member and Associate Professor

      Department of Pathology

      Moffitt Cancer Center

      12902 USF Magnolia Drive

      Tampa, FL 33612 (USA)

      [email protected]

      Library of Congress Cataloging-in-Publication Data

      Names: Centeno, Barbara A., editor. | Dhillon, Jasreman, editor.

      Title: Pancreatic tumors / volume editors, Barbara A. Centeno, Jasreman Dhillon.

      Other titles: Pancreatic tumors (Centeno) | Monographs in clinical cytology ; v. 26. 0077-0809

      Description: Basel ; Hartford : Karger, 2020. | Series: Monographs in clinical cytology, 0077-0809 ; vol. 26 | Includes bibliographical references and indexes. | Summary: “This book provides a comprehensive review of entities that may be encountered in pancreatic cytology. It is designed for cytotechnologists, pathology trainees, pathologists, and cytopathologists. It is also a useful guide for advanced endoscopists performing EUS-guided FNA, and surgeons and oncologists treating patients with pancreatic disease wanting to understand their pathology reports”-- Provided by publisher.

      Identifiers: LCCN 2020022626 (print) | LCCN 2020022627 (ebook) | ISBN 9783318066036 (hardcover ; alk. paper) | ISBN 9783318066043 (ebook)

      Subjects: MESH: Pancreatic Neoplasms

      Classification: LCC RC280.P25 (print) | LCC RC280.P25 (ebook) | NLM W1 MO567KF v.26 2020 | DDC 616.99/437--dc23

      LC record available at https://lccn.loc.gov/2020022626

      LC ebook record available at https://lccn.loc.gov/2020022627

      Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents^®.

      Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

      Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.

      All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

      © Copyright 2020 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)

       www.karger.com

      Printed on acid-free and non-aging paper (ISO 9706)

      ISSN 0077–0809

      ISBN 978–3–318–06603–6

      e-ISBN 978–3–318–06604–3

      Published online: September 29, 2020

      Centeno BA, Dhillon J (eds): Pancreatic Tumors. Monogr Clin Cytol. Basel, Karger, 2020, vol 26, pp VI–VII (DOI:10.1159/000506356)

      ______________________

       Preface

      Image-guided fine-needle aspiration (FNA) of the pancreas using either transabdominal ultrasound or CT scan was first utilized and reported in the 1970s, eventually replacing laparotomy with wedge biopsy of the pancreas as the favored means of sampling pancreatic masses. In fact, this was the state of the field when the senior editor, Dr. Centeno was first introduced to pancreatic cytopathology as a first-year resident in 1988–1989. Endoscopic ultrasound (EUS)-guided FNA was first reported in 1992 as a means of guiding pancreatic aspiration. Initially received with some skepticism, it is now the preferred method used to perform FNA of the pancreas in many institutions throughout the world. The specific imaging features of many pancreatic lesions, using CT scan, transabdominal ultrasound, EUS, and now more advanced methods, such as magnetic resonance imaging and magnetic resonance cholangiopancreatography, have been described in detail.

      Early publications on the cytology of the pancreas described the cytological features of ductal adenocarcinoma and its distinction from pancreatitis. As experience increased, the 1980s and 1990s saw numerous publications describing the cytological features of non-ductal neoplasms, as well as uncommon entities such as solid pseudopapillary neoplasm, formerly known as Frantz tumor, and pancreatoblastoma. A robust body of work also led to the development of increasingly specific criteria for the challenging diagnosis of pancreatic ductal adenocarcinoma. Pancreatic cyst cytology was the next frontier of pancreatic cytology to be explored in the 1990s. In fact, the senior editor’s first project in pancreatic cytopathology – started in her fellowship year in cytopathology – was to describe the cytological features of pancreatic cyst aspirates, derived from resection specimens. The recognition of the distinction of mucinous from non-mucinous lesions using cytology and measuring CEA cyst fluid levels was the next advance. FNA of pancreatic cysts is now accepted as part of the management protocol of patients with pancreatic cysts.

      Yet, despite improved understanding of the cytological features of many entities, there remained challenging entities for which sensitivity of cytopathology is variable. More recently, evolution of the understanding of the genetics of pancreatic neoplasms has led to the development of immunohistochemical antibodies and molecular panels that provide more specific diagnoses and prognoses.

      Pancreatic cytology is best practiced in a multidisciplinary manner. Accurate interpretation of the pancreatic cytology sample requires correlation