Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity of small and large molecules Provides detailed information on useful chiral stationary phases (CSPs) for HPLC Includes handy information on selection of an appropriate CSP, including mechanistic studies Offers strategies for fast method development with HPLC, SFC, and CE Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
This book describes the way that pharmaceutical projects and programs are currently managed, and offers views from many highly experienced practitioners from within the industry on future directions for drug program management. The book integrates portfolio, program, and project management processes as fundamental for effective and efficient drug product development. Contributing expert authors provide their view of how the projectization approach can be taken forward by the drug industry over the coming years.
Vor 200 Jahren wurde einer der gro?ten und bis heute umstrittenen Naturforscher geboren: Charles Darwin. Der Autor Wolfgang Schaumann schildert in seiner kritischen Wurdigung von Darwins Lebenswerk historische und hochst aktuelle Auseinandersetzungen mit Darwins revolutionarer Theorie zur Evolution der Arten, die erstmals im Jahre 1859 von ihm veroffentlicht wurde. In einem Spannungsbogen, der sich uber 150 Jahre hinzieht, lasst Schaumann den Leser miterleben, wie Darwins revolutionare Theorie allen gegen sie vorgebrachten Argumenten getrotzt hat und sich gegen samtliche Alternativtheorien immer wieder durchsetzen konnte. Spannend und lehrreich zugleich!
This enlightening book makes visible the lives and works of women who played a critical role in the development of geography as an academic field. A rare and detailed analysis of the geographical work of 30 individual women geographers from 1850 to 1970 Includes oral histories from women who have held appointments in British universities since World War II Makes the work of women geographers visible and challenges the notion of pre 1970s geography as an overwhelmingly masculine field Makes an important contribution to debates about the theoretical and methodological framing of the historiography of geography
Introduces number operators with a focus on the relationship between quantum mechanics and social science Mathematics is increasingly applied to classical problems in finance, biology, economics, and elsewhere. Quantum Dynamics for Classical Systems describes how quantum tools—the number operator in particular—can be used to create dynamical systems in which the variables are operator-valued functions and whose results explain the presented model. The book presents mathematical results and their applications to concrete systems and discusses the methods used, results obtained, and techniques developed for the proofs of the results. The central ideas of number operators are illuminated while avoiding excessive technicalities that are unnecessary for understanding and learning the various mathematical applications. The presented dynamical systems address a variety of contexts and offer clear analyses and explanations of concluded results. Additional features in Quantum Dynamics for Classical Systems include: Applications across diverse fields including stock markets and population migration as well as a unique quantum perspective on these classes of models Illustrations of the use of creation and annihilation operators for classical problems Examples of the recent increase in research and literature on the many applications of quantum tools in applied mathematics Clarification on numerous misunderstandings and misnomers while shedding light on new approaches in the field Quantum Dynamics for Classical Systems is an ideal reference for researchers, professionals, and academics in applied mathematics, economics, physics, biology, and sociology. The book is also excellent for courses in dynamical systems, quantum mechanics, and mathematical models.
A ground-breaking and practical treatment of probability and stochastic processes A Modern Theory of Random Variation is a new and radical re-formulation of the mathematical underpinnings of subjects as diverse as investment, communication engineering, and quantum mechanics. Setting aside the classical theory of probability measure spaces, the book utilizes a mathematically rigorous version of the theory of random variation that bases itself exclusively on finitely additive probability distribution functions. In place of twentieth century Lebesgue integration and measure theory, the author uses the simpler concept of Riemann sums, and the non-absolute Riemann-type integration of Henstock. Readers are supplied with an accessible approach to standard elements of probability theory such as the central limmit theorem and Brownian motion as well as remarkable, new results on Feynman diagrams and stochastic integrals. Throughout the book, detailed numerical demonstrations accompany the discussions of abstract mathematical theory, from the simplest elements of the subject to the most complex. In addition, an array of numerical examples and vivid illustrations showcase how the presented methods and applications can be undertaken at various levels of complexity. A Modern Theory of Random Variation is a suitable book for courses on mathematical analysis, probability theory, and mathematical finance at the upper-undergraduate and graduate levels. The book is also an indispensible resource for researchers and practitioners who are seeking new concepts, techniques and methodologies in data analysis, numerical calculation, and financial asset valuation. Patrick Muldowney, PhD, served as lecturer at the Magee Business School of the UNiversity of Ulster for over twenty years. Dr. Muldowney has published extensively in his areas of research, including integration theory, financial mathematics, and random variation.
Vom Denken der Technik oder wie Technik und Kultur die Welt verandern Wie eng Geistes- und Naturwissenschaften zusammenhangen, zeigt Karl Wilhelm Boddeker. In seiner geschichtlichen Betrachtung fokussiert sich Boddeker nicht auf allseits bekannte Beispiele wie die industrielle Revolution, sondern widmet sich vor allem auch brennenden und ungelosten Fragen der Gegenwart anhand der existenziellen Themen Wasser und Energie. Das Sachbuch ist nicht nur informativ, sondern auch aktuell und politisch. Eine zum Nach- und Umdenken anregende Lekture fur Naturwissenschaftler und alle interessierten Leser. Naturwissenschaftlicher Erkenntnisgewinn und kulturelle Entwicklung Wasser und Energie sind Boddekers zentrale Themen. In den Kapiteln >Wasser – die unverbrauchbare Ressource< und >Energie – Woher, wohin, wofur, wie viel?< geht der Autor der ubergeordneten Frage nach, wie sich naturwissenschaftlichtechnischer Erkenntnisgewinn uberhaupt abspielt und wie er mit der kulturellen Entwicklung einhergeht. Galten Natur- und Geisteswissenschaften lange als strikte Gegensatze, zeigt Karl Wilhelm Boddeker hier in einem modernen Ansatz, wie eng Technik und Kultur eigentlich zusammenhangen und das Leben und Denken der Menschen beeinflussen.
John Zinkin's new book on Challenges in Implementing Corporate Governance is a welcome addition for board members and senior management on how to improve corporate governance in the post-crisis period. John correctly identifies that most boards on underperforming companies have three elements of failure: a lack of proper understanding of the business and its strategy; a total lack of appreciation of both the strategic and systemic risks created by new product markets; and a total failure by boards to ensure that the incentive structures for top management reflect long-term needs rather than short-term profits, thereby putting the company's future at risk. John has written a useful and practical handbook that is a must read for all board members on how to improve corporate governance. —Datuk Seri Panglima Andrew Sheng, Chief Adviser, China Banking Regulatory Commission and the Boards of the Qatar Financial Centre Regulatory Authority , Sime Darby Berhad and Khazanah Nasional «This timely book will interest those wanting to improve corporate governance and risk management. It should also appeal to anyone curious about what caused banks to fail in a number of markets in recent times, and the values which led to this failure. In considering principles which are essential to good governance, ACCA recognizes that corporate governance evolves and improves over time. We accept that organizations in different sectors and across the world operate in diverse environments in terms of culture, regulation, legislation and enforcement. What is appropriate, in terms of governance, for one type of organization will not be appropriate to all organizations. John Zinkin’s book seeks to address this challenge, analyzing the essential cultural and behavioral issues which sit at the heart of the challenges.» —Paul Moxey, Head of Risk Management and Corporate Governance, Association of Chartered Certified Accountants «A scholarly combination of practical guidelines and strategic vision.» —Lady Sylvia Jay CBE, Vice-Chairman, L'Oreal UK; Independent Director, Alcatel-Lucent, Compagnie de Saint Gobain, Lazard Limited and Carrefour «This is a highly topical and timely publication. Globally, the crisis that has gripped the financial services sector following the failure of well known global banks in recent years has focused attention on corporate governance. To restore confidence in the financial services sector is a long-term goal and effective corporate governance, together with the closely associated topic of risk management, has gripped not only governments and banks, but the public too. In this book, John Zinkin clearly asserts that financial institutions need to exert their responsibilities beyond their shareholders and far more into the wider group of stakeholders, including employees and wider society. In considering issues globally, John provides a book that is not only thought-provoking but pragmatic and useful at a time when stakeholders in our banks need to see real change in transparent, practical ways from those charged with governing our banks.» —Ruth Martin, Managing Director, The Chartered Institute of Securities and Investment
If higher education is to fulfill its vital social mission, new department leaders must be prepared for their positions and get up to speed on the basics quickly, educating themselves about the role and continuing to learn on the job. In this second edition of his classic resource, Don Chu outlines the proven ideas and strategies new department chairs need in order to do their jobs well. Thoroughly revised and updated, The Department Chair Primer contains information that addresses the current pressures and challenges in higher education and offers practical suggestions for responding to them. Filled with illustrative examples, the book gets straight to the heart of challenges and issues. Each chapter details a particular problem, includes a brief introduction to the topic, and provides tips on how to deal with the situation. Covering a wealth of topics, The Department Chair Primer Explores the chair's role as department leader Offers suggestions for handling stress and conflict Includes information on budgeting, resource management, and development Contains strategies for professional development, people management, and working with challenging personnel Presents ideas for handling department communications, student development, and strategic positioning Written in a concise and accessible manner, The Department Chair Primer is an ideal resource for the busy new department chair.
A concise, visually based introduction to graphic design methodologies Graphic design has emerged as a discipline complete with a body of scholarly literature devoted to its underlying theory. Introduction to Graphic Design Methodologies and Processes contributes to this expanding discourse by illustrating the value of qualitative and quantitative methodologies in guiding conceptual development in ways beyond those based on taste, style, and personal preference. Introduction to Graphic Design Methodologies and Processes: Introduces a range of practical methodologies pertinent to the interpreting, targeting, and creating of forms and messages Furthers the ability of designers by showing them how to design creatively, collaboratively, and strategically, and as a result, helps them move from form-makers to cultural participants—a transformative trend for design professionals Includes case studies with questions and answers contributed by a diverse group, including Second Story and Sol Sender As professional designers play more strategic roles, the need for material on design methodologies is growing. This concise, visually based introduction to the topic is the designer's definitive resource for defining their purpose, and producing work that is original, appropriate, responsible—and inspiring.