Presents the latest research and applications for a new, promising approach to fighting infectious diseases Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications. The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores: A new approach to controlling infections using Gram-negative bacteria Bacteriophage holins and their membrane-disrupting activity Anti-staphylococcal lytic enzymes Membrane-targeted enzybiotics Design of phage cocktails for therapy from a host-range point of view Novel methods to identify new enzybiotics Genetically modified phages that deliver suicidal genes to target bacteria The authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature. As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.
Biological Diversity takes a fresh, innovative approach to the teaching of biodiversity. Rather than detailing and cataloguing the major taxa and their evolutionary relationships, the authors have selected 18 groups of organisms and used these as a framework in which to discuss the species and their interactions with man and each other. There is a strong narrative theme throughout – the exploited and the exploiters – and, in many cases, there is emphasis on the historical context. A wide range of organisms are covered, from the unicellular to birds and mammals and with an equal consideration of plants and animals. Species have been chosen for their ability to best illustrate particular biological principles, and for their strong interaction with other species. After an introduction the book is divided into two parts: ‘Exploited’ and ‘Exploiters’. Each of the chapters, although linked to each other, forms a stand-alone essay. They are scientifically rigorous, up-to-date and do not shy away from addressing some controversial issues. Chapters have’ text boxes’ highlighting important issues and concepts, lists of further reading and references. In addition to tables and figures the book has a selection of original illustrations drawn by leading artist Steven Appleby. This fresh approach will appeal to all those interested in the biological sciences, and aims to be accessible to people with a diversity of backgrounds. It will prove particularly useful to biology students, enabling them to get to grips with important biological principles and concepts that underpin the diversity of life, and the interrelationship of humans with other groups of organisms.
The Duffing Equation: Nonlinear Oscillators and their Behaviour brings together the results of a wealth of disseminated research literature on the Duffing equation, a key engineering model with a vast number of applications in science and engineering, summarizing the findings of this research. Each chapter is written by an expert contributor in the field of nonlinear dynamics and addresses a different form of the equation, relating it to various oscillatory problems and clearly linking the problem with the mathematics that describe it. The editors and the contributors explain the mathematical techniques required to study nonlinear dynamics, helping the reader with little mathematical background to understand the text. The Duffing Equation provides a reference text for postgraduate and students and researchers of mechanical engineering and vibration / nonlinear dynamics as well as a useful tool for practising mechanical engineers. Includes a chapter devoted to historical background on Georg Duffing and the equation that was named after him. Includes a chapter solely devoted to practical examples of systems whose dynamic behaviour is described by the Duffing equation. Contains a comprehensive treatment of the various forms of the Duffing equation. Uses experimental, analytical and numerical methods as well as concepts of nonlinear dynamics to treat the physical systems in a unified way.
Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant co-morbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder. There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is clinically relevant and meaningful for a clinician. The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have assembled a team of experts from around the world: in many instances, chapters are co-authored by people from different continents, bringing a truly international perspective to this important topic. The book covers the basic science of the pathology underlying bipolar disorder but addresses the clinical aspects of the disease throughout. The book comprises four sections: Descriptive Aspects—issues ranging from how the concept of bipolar disorder has evolved over the years to new information about neurocognitive impairment, creativity and economic productivity, and to discussion of the deliberations of the DSM-V committee on changes in diagnostic categories and criteria. Biology—the contribution of genes to this disorder, changes in circadian rhythms, what we know about brain changes and the role of oxidative stress. Biological Treatment and Psychosocial Treatment— all the latest information about pharmacological and psychological treatments and the optimal management of this condition. If you want to provide state-of-the-art care to your bipolar patients, be sure to consult this authoritative reference.
The Excellent Online Instructor is a guide for new and seasoned faculty who teach online, those responsible for training and developing online instructors, and administrators who must evaluate online faculty performance. This comprehensive resource describes the qualities of and explains how one can become an excellent online instructor. Written by Rena M. Palloff and Keith Pratt—noted experts in online instruction—the book Includes models based in adult learning principles and best practices Offers guidelines to test instructors' readiness to teach online Contains ideas for overcoming faculty resistance Reveals how to develop an effective mentoring program Shows how to establish a long-term faculty development effort Praise for The Excellent Online Instructor «Palloff and Pratt have a profound understanding of the online educational milieu, its complexities and challenges as well as the potential it opens up to serious educators dedicated to exploiting its full value. Practical and down-to-earth strategies are at the core of what the authors offer the reader in this engaging book.» —Michael J. Canuel, CEO, LEARN Quebec «This book examines best practices for effective online teaching and instructor engagement and provides a concise plan for faculty development and effective training methods. Rena Palloff and Keith Pratt have provided another essential resource for the field of online teaching and learning that is a must-read for anyone working with faculty or teaching online in either higher education or K–12.» —Kaye Shelton, dean, Online Education, Dallas Baptist University «Whether you are guiding departmental faculty or looking to improve your own online skills, Palloff and Pratt provide practical steps, tools to organize your processes, best practices to emulate, and valuable resources to help you achieve excellence online.» —Lynn Olson, dean, Graduate and Professional Studies, St. Joseph's College Online
This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
Basin Analysis is an up-to-date overview of the essential processes of the formation and evolution of sedimentary basins, and their implications for the development of hydrocarbon resources. The new edition features: A consideration of the fundamental physical state of the lithosphere. A discussion on the major types of lithospheric deformation relevant to basin development – stretching and flexure. A new chapter on the effects of mantle dynamics. Radically revised chapters on the basin-fill. A new chapter on the erosional engine for sediment delivery to basins, reflecting the massive and exciting advances in this area in the last decade. Expansion of the techniques used in approaching problems in basin analysis. Updated chapters on subsidence analysis and measurements of thermal maturity of organic and non-organic components of the basin-fill. New material on thermochronological and exposure dating tools. Inclusion of the important petroleum system concept in the updated section on the application to the petroleum play. Visit: www.blackwellpublishing.com/allen for practical exercises related to problems in Basin Analysis 2e. To run the programs you will need a copy of Matlab 6 or 7. An Instructor manual CD-ROM for this title is available. Please contact our Higher Education team at [email protected] for more information.
Undergraduate students come to college from a myriad of pathways for a variety of purposes, and the same can be said of them as they leave to head off into their next endeavors. Arguably, the most important goal of higher education is to prepare students to achieve their postcollege aspirations, and campuses typically pursue that goal through a combination of curricular and co-curricular programs and services for students. This issue offers readers a glimpse into contemporary context and practice related to helping students with their after-college transition from one form of education (two-year or four-year) to the next (four-year, graduate, or professional school), from education to workforce, or from education to military service. This is the 138th volume of this Jossey-Bass higher education quarterly series. An indispensable resource for vice presidents of student affairs, deans of students, student counselors, and other student services professionals, New Directions for Student Services offers guidelines and programs for aiding students in their total development: emotional, social, physical, and intellectual.
Tectonic geomorphology is the study of the interplay between tectonic and surface processes that shape the landscape in regions of active deformation and at time scales ranging from days to millions of years. Over the past decade, recent advances in the quantification of both rates and the physical basis of tectonic and surface processes have underpinned an explosion of new research in the field of tectonic geomorphology. Modern tectonic geomorphology is an exceptionally integrative field that utilizes techniques and data derived from studies of geomorphology, seismology, geochronology, structure, geodesy, stratigraphy, meteorology and Quaternary science. While integrating new insights and highlighting controversies from the ten years of research since the 1st edition, this 2nd edition of Tectonic Geomorphology reviews the fundamentals of the subject, including the nature of faulting and folding, the creation and use of geomorphic markers for tracing deformation, chronological techniques that are used to date events and quantify rates, geodetic techniques for defining recent deformation, and paleoseismologic approaches to calibrate past deformation. Overall, this book focuses on the current understanding of the dynamic interplay between surface processes and active tectonics. As it ranges from the timescales of individual earthquakes to the growth and decay of mountain belts, this book provides a timely synthesis of modern research for upper-level undergraduate and graduate earth science students and for practicing geologists. Additional resources for this book can be found at: www.wiley.com/go/burbank/geomorphology.
The Earth’s ecosystems are in the midst of an unprecedented period of change as a result of human action. Many habitats have been completely destroyed or divided into tiny fragments, others have been transformed through the introduction of new species, or the extinction of native plants and animals, while anthropogenic climate change now threatens to completely redraw the geographic map of life on this planet. The urgent need to understand and prescribe solutions to this complicated and interlinked set of pressing conservation issues has lead to the transformation of the venerable academic discipline of biogeography – the study of the geographic distribution of animals and plants. The newly emerged sub-discipline of conservation biogeography uses the conceptual tools and methods of biogeography to address real world conservation problems and to provide predictions about the fate of key species and ecosystems over the next century. This book provides the first comprehensive review of the field in a series of closely interlinked chapters addressing the central issues within this exciting and important subject. View www.wiley.com/go/ladle/biogeography yo access the figures from the book.