Diese fur Studierende ebenso wie fur Wissenschaftler, Ingenieure und Praktiker geeignete Einfuhrung in mathematische Modellbildung und Simulation setzt nur einfache Grundkenntnisse in Analysis und linearer Algebra voraus – alle weiteren Konzepte werden im Buch entwickelt. Die Leserinnen und Leser lernen auf der Grundlage vieler Beispiele aus unterschiedlichsten Gebieten (Biologie, Okologie, Okonomie, Medizin, Landwirtschaft, Chemie, Maschinenbau, Elektrotechnik, Prozesstechnik usw.), sich kritisch mit mathematischen Modellen auseinanderzusetzen und anspruchsvolle mathematische Modelle selbst zu formulieren und zu implementieren. Das Themenspektrum reicht von statistischen Modellen bis zur Mehrphasen-Stromungsdynamik in 3D. Alle im Buch besprochenen Modellklassen konnen mit kostenloser Open-Source-Software simuliert werden. Grundlage ist das eigens fur dieses Buch entwickelte Computerbetriebssystem Gm.Linux («Geisenheim-Linux»), das ohne Installationsaufwand auch z.B. auf Windows-Rechnern genutzt werden kann. Ein Referenzkartensystem zu Gm.Linux mit einfachen Schritt-fur-Schritt-Anleitungen ermoglicht es, auch komplexe statistische Berechnungen oder 3D-Stromungssimulationen in kurzer Zeit zu realisieren. Alle im Buch beschriebenen Verfahren beziehen sich auf Gm.Linux 2.0 (und die darin fixierten Versionen aller Anwendungsprogramme) und sind damit unabhangig von Softwareaktualisierungen langfristig funktionstuchtig. Aus dem Inhalt: – Grundlagen mathematischer Modellbildung und Simulation – Phanomenologische und mechanistische Modelle – Statistik und Differentialgleichungen (ODE?s und PDE?s) – Open Source Software, u.a. OpenFOAM (3D CFD), R (ODE?s und statistische Analysen), Gm.HYDRA (Reproducible Research), Six Sigma, – Prozessoptimierung, Qualitatsmanagement, Datenbanken, Versuchsplanung, Random-Forest, Entscheidungsbaume, gemischte Hauptkomponenten-/Korrespondenzanalysen, Klassifikation, Big Data – mit Crashkursen R und Maxima – Eigenes Betriebssystem Gm.Linux fur Modellbildung und Simulation – Mit Gastbeitragen aus Industrie und Forschung
Written by an international team of leading scholars, this groundbreaking reference work explores the nature of language change and diffusion, and paves the way for future research in this rapidly expanding interdisciplinary field. Features 35 newly-written essays from internationally acclaimed experts that reflect the growth and vitality of the burgeoning area of historical sociolinguistics Examines how sociolinguistic theoretical models, methods, findings, and expertise can be used to reconstruct a language's past in order to explain linguistic changes and developments Bridges the gap between the past and the present in linguistic studies Structured thematically into sections exploring: origins and theoretical assumptions; methods for the sociolinguistic study of the history of languages; linguistic and extra-linguistic variables; historical dialectology, language contact and diffusion; and attitudes to language
The Psychology of Coaching, Mentoring, and Learning addresses the psychological principles upon which coaching and mentoring is based, and integrates them in a universal framework for the theory and practice of individual and organizational development. The second edition is updated with the latest research, taking into account the increasing importance of positive psychology and its role in coaching and mentoring with an emphasis on strength, growth, and development. Combining high-level theory with practical applications and case studies, this is an invaluable resource for coaches, mentors, trainers, psychologists, executives, managers, and students.
The Middle East has long been fraught with tension and volatility. However, the recent Arab uprisings have intensified instability, turning this 'hot-spot' into a veritable tinderbox whose potential for implosion has far-reaching regional and global consequences. In this short book, leading Middle East scholar Mohammed Ayoob argues that the Arab Spring has both changed and charged some of the region’s thorniest problems – from the rise of political Islam to Iran’s nuclear ambitions, the Israel-Palestine conflict to rivalries between key regional powers. Exploring the sources of conflict in the Middle East and their various linkages, Ayoob offers a thoughtful and balanced assessment of whether the region is indeed destined for implosion or whether political sagacity and diplomatic creativity can bring it back from the brink.
As a new department chair, you face many challenges?chief among them that you likely received little or no formal training in academic leadership. You may feel that you face these challenges alone, but in fact a wealth of information and time-tested techniques have been collected over the years from experienced academic administrators. For the first time, this booklet brings together some of the best guidance and strategies that have appeared in The Department Chair, resulting in a collection that is highly relevant to a new chair?s work. The advice contained in these pages can help you build the skills necessary to successfully lead your department. This booklet is full of practical advice that can be put to use immediately, and each article is concisely written so you won?t have to spend valuable time searching for a solution or technique. Whether you?re looking for information on how to work more effectively with your dean, how to better manage your time, how to conduct successful department meetings, or how to best facilitate change, this booklet will help?it covers all these topics and more, from the basics to the specifics. This booklet is structured to provide guidance in four critical areas: chair as leader, getting started, managing conflict, and helping faculty and students thrive. The articles were selected to provide you with timely, comprehensive information. They detail effective practice and represent the best, most innovative thinking on topics and situations you will regularly encounter. This essential resource will become your personal guide as you navigate the responsibilities of your new role as department chair.
Phosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies.
This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of «omic» data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of «omic» data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations
It can seem at times as though all of academic administration today is focused only on the need for continual change and the endless pursuit of «the big idea.» But most academic leaders, from department chairs and program directors through university presidents and chancellors, are far too busy helping their institutions flourish for them to divert critical energy and resources to yet another untried theory or management principle. Academic Leadership Day by Day takes an entirely different approach to developing your proven academic leadership: It introduces one practical and field-tested idea each day for an entire academic year. Rather than requiring you to devote days or even weeks to administrative training (which may prove to be of little use in the end), this manual gives you no-nonsense suggestions that you can consider on even your busiest days. Experiment with the suggestions made each day, discover what works for you, and then build on your successes for the benefit of your institution and its programs. Significant improvements often result from small, gradual, and consistent efforts, and Academic Leadership Day by Day is your guide to becoming a more accomplished, confident academic leader a few minutes at a time.
This series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. Topics included in this volume include recent developments in classical density functional theory, nonadiabatic chemical dynamics in intermediate and intense laser fields, and bilayers and their simulation.
The Advances in Chemical Physics series presents the cutting edge in every area of the discipline and provides the field with a forum for critical, authoritative evaluations of advances. It provides an editorial framework that makes each volume an excellent supplement to advanced graduate classes, with contributions from experts around the world and a handy glossary for easy reference on new terminology. This series is a wonderful guide for students and professionals in chemical physics and physical chemistry, from academia, government, and industries including chemicals, pharmaceuticals, and polymers.