Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураBasics of Analytical Chemistry and Chemical Equilibria
Enables students to progressively build and apply new skills and knowledge Designed to be completed in one semester, this text enables students to fully grasp and apply the core concepts of analytical chemistry and aqueous chemical equilibria. Moreover, the text enables readers to master common instrumental methods to perform a broad range of quantitative analyses. Author Brian Tissue has written and structured the text so that readers progressively build their knowledge, beginning with the most fundamental concepts and then continually applying these concepts as they advance to more sophisticated theories and applications. Basics of Analytical Chemistry and Chemical Equilibria is clearly written and easy to follow, with plenty of examples to help readers better understand both concepts and applications. In addition, there are several pedagogical features that enhance the learning experience, including: Emphasis on correct IUPAC terminology «You-Try-It» spreadsheets throughout the text, challenging readers to apply their newfound knowledge and skills Online tutorials to build readers' skills and assist them in working with the text's spreadsheets Links to analytical methods and instrument suppliers Figures illustrating principles of analytical chemistry and chemical equilibria End-of-chapter exercises Basics of Analytical Chemistry and Chemical Equilibria is written for undergraduate students who have completed a basic course in general chemistry. In addition to chemistry students, this text provides an essential foundation in analytical chemistry needed by students and practitioners in biochemistry, environmental science, chemical engineering, materials science, nutrition, agriculture, and the life sciences.
A Companion to the History of Science
The Wiley Blackwell Companion to the History of Science is a single volume companion that discusses the history of science as it is done today, providing a survey of the debates and issues that dominate current scholarly discussion, with contributions from leading international scholars. Provides a single-volume overview of current scholarship in the history of science edited by one of the leading figures in the field Features forty essays by leading international scholars providing an overview of the key debates and developments in the history of science Reflects the shift towards deeper historical contextualization within the field Helps communicate and integrate perspectives from the history of science with other areas of historical inquiry Includes discussion of non-Western themes which are integrated throughout the chapters Divided into four sections based on key analytic categories that reflect new approaches in the field
The Engineering of Human Joint Replacements
Since the major pioneering of joint replacement surgery more than fifty years ago, much research and progress has been made in the field of arthroplasty with new insights into better materials, types of cement and bone-cell compatible coatings, and a better understanding of the causes of implant failure. With an increasingly ageing population the requirement for arthroplastic surgery is manifest; over 800,000 hips worldwide are replaced each year, and replacement surgery is performed for almost every joint of the body. The Engineering of Human Joint Replacements covers the design, engineering, production and manufacture of human joint replacements, as well as associated engineering concerns such as surface coatings, orthopedic bone cement, the causes and effects of wear and tear, and rapid prototyping for clinical evaluation. Materials evaluation and selection is discussed, as well as production processes and insertion methods. The author provides an overview of skeletal anatomy and the effects of pain and deterioration in order to put the engineering principles into a medical context. Examples of joint replacements for the most common regions of the body are included, and aspects of clinical studies of these cases are discussed. Key Features: • Provides an overview of the engineering materials and processes involved in the manufacture of human joint replacements • Sets the scene for engineers and clinicians embarking on research into joint replacements • Includes clinical and industrial examples and points the way to future developments • Provides information on medical device companies with an engineering guide to the requirements for joint replacement The Engineering of Human Joint Replacements bridges the divide between engineering and orthopaedic surgery, offering an introductory text to young engineers entering the field, as well as a reference for medical staff who will benefit from an understanding of the materials and methods used in their design, engineering and manufacture.
Mass Spectrometry for Drug Discovery and Drug Development
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
Physical Chemistry of Semiconductor Materials and Processes
The development of solid state devices began a little more than a century ago, with the discovery of the electrical conductivity of ionic solids. Today, solid state technologies form the background of the society in which we live. The aim of this book is threefold: to present the background physical chemistry on which the technology of semiconductor devices is based; secondly, to describe specific issues such as the role of defects on the properties of solids, and the crucial influence of surface properties; and ultimately, to look at the physics and chemistry of semiconductor growth processes, both at the bulk and thin-film level, together with some issues relating to the properties of nano-devices. Divided into five chapters, it covers: Thermodynamics of solids, including phases and their properties and structural order Point defects in semiconductors Extended defects in semiconductors and their interactions with point defects and impurities Growth of semiconductor materials Physical chemistry of semiconductor materials processing With applications across all solid state technologies,the book is useful for advanced students and researchers in materials science, physics, chemistry, electrical and electronic engineering. It is also useful for those in the semiconductor industry.
Chemical Synthesis of Nucleoside Analogues
Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Heterocyclic Chemistry in Drug Discovery
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
NMR Data Interpretation Explained. Understanding 1D and 2D NMR Spectra of Organic Compounds and Natural Products
Through numerous examples, the principles of the relationship between chemical structure and the NMR spectrum are developed in a logical, step-by-step fashion Includes examples and exercises based on real NMR data including full 600 MHz one- and two-dimensional datasets of sugars, peptides, steroids and natural products Includes detailed solutions and explanations in the text for the numerous examples and problems and also provides large, very detailed and annotated sets of NMR data for use in understanding the material Describes both simple aspects of solution-state NMR of small molecules as well as more complex topics not usually covered in NMR books such as complex splitting patterns, weak long-range couplings, spreadsheet analysis of strong coupling patterns and resonance structure analysis for prediction of chemical shifts Advanced topics include all of the common two-dimensional experiments (COSY, ROESY, NOESY, TOCSY, HSQC, HMBC) covered strictly from the point of view of data interpretation, along with tips for parameter settings
A Handbook for DNA-Encoded Chemistry. Theory and Applications for Exploring Chemical Space and Drug Discovery
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Strange Chemistry. The Stories Your Chemistry Teacher Wouldn't Tell You
This book opens the audience’s eyes to the extraordinary scientific secrets hiding in everyday objects. Helping readers increase chemistry knowledge in a fun and entertaining way, the book is perfect as a supplementary textbook or gift to curious professionals and novices. • Appeals to a modern audience of science lovers by discussing multiple examples of chemistry in everyday life • Addresses compounds that affect everyone in one way or another: poisons, pharmaceuticals, foods, and illicit drugs; thereby evoking a powerful emotional response which increases interest in the topic at hand • Focuses on edgy types of stories that chemists generally tend to avoid so as not to paint chemistry in a bad light; however, these are the stories that people find interesting • Provides detailed and sophisticated stories that increase the reader’s fundamental scientific knowledge • Discusses complex topics in an engaging and accessible manner, providing the “how” and “why” that takes readers deeper into the stories