Медицина
Различные книги в жанре МедицинаOrganic Chemistry of Drug Degradation
The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.
How to Talk to Your Doctor
Showing patients how to take control of their own health care, this guide reveals how to navigate the maze of prescriptions and tests and offers advice for those who act as medical advocates for their children, aging parents, or others.
The Cure
Focusing on the entire healthcare system and all of its various stakeholders, <i>The Cure</i> aims to provide a roadmap inclusive of both legislative and societal changes needed to improve the method by which healthcare is accessed, delivered and financed within the United States. With detailed analysis investigating both the cause and current status of major problems within the healthcare space, The Cure is able to provide insight and guidance to begin solving those issues. This book is written in a non-partisan manner and wastes no time with finger pointing, instead focusing on realistic goals and practical solutions to elevate and enhance the healthcare system. Outlining the need for transparency, reasonable regulation, and consumer engagement, along with other key drivers of cost and inefficiencies in healthcare, Seth Denson uses his vast industry experience to shine a spotlight on what is keeping America’s healthcare system sick, but more importantly, outline what is needed to cure it.
Unwritten Rules of Social Relationships
Born with autism, both Temple Grandin and Sean Barron now live famously successful social lives. However, their paths were quite different. Temple's logical mind controlled her social behavior. She interacted with many adults and other children, experiencing varied social situations. Logic informed her decision to obey social rules and avoid unpleasant consequences. Sean's emotions controlled his social behavior. Baffled by social rules, isolated and friendless, he made up his own, and applied them to others. When they inevitably broke his rules, he felt worthless and unloved. Both Temple and Sean ultimately came to terms with the social world and found their places in it. Whether you are a person with autism, a caregiver in the autism community, or just someone interested in an outsider view of society, their powerful stories will enthrall and enlighten you. </p>
In My Mind
This unique book brings a depth of understanding of the analytical skills that 21-yr old Alex has brought to his own condition. As Alex says, «There are varying types of Asperger's and young people cannot all be squeezed into having the same diagnostic symptoms. But what they do have are some correlation to the symptoms laid out by Hans Asperger.» ( Please note Asperger's may now be described as the lower end of the Autistic scale.) In his book, Alex takes each of eight symptoms and comments how these symptoms are pertinent in his life. In so doing, the reader will find similarities to those children with Asperger's that they know and will be able to reflect with new insights on what Alex is talking about. In addition to the above, Alex shares many experiences in his life that reflect his Asperger's condition from not being able to drive, social development, repetitions, panic situations, holidays, family, movies, relaxers, etc. Alex has augmented his insights with graphics that even more clearly clarify his Asperger's symptoms and sheds new ways of seeing the Asperger's condition. In reading this book, the, reader will clarify in his/her mind the characteristics common to the children that he/she knows. Along the way Alex is brought to tears in recounting the unpleasantness of his experiences. At the same time, there are moments of great hilarity in the retelling of episodes that have a sense of the comedic in them.<BR> <br> The second part of Alex's book is a re-counting of his life experiences, explaining why he can't drive, how he relates to his family, his school experiences, the things that relax him and those which may cause him near panic. From each experience the reader will assess the lessons learned and how it relates to the children he/she may know. In the addendum, significant family members and friends assess Alex's Asperger's diagnosis. This is extremely helpful in to the reader in that many of the problems in dealing with children with Asperger's/Autism are similar to Alex's. Every child with Asperger's has some gift. Alex's gift is his ability to penetrate to the core of his Asperger's Syndrome and then is able to articulate his response in such a way as to enlighten the reader. Added to this is a great sense of metaphor, which is highlighted by multiple graphics in the book.
Behavior Solutions for the Home and Community
Behavior Solutions for the Home is a tool for parents who have children whose behaviors are impeding their daily life. Once they see a particular behavior, they can quickly look up an in-the-moment solution, and then read more about what could be causing that behavior, and more importantly, how to overcome it. This helpful book is intended to provide general, practical solutions for busy (and often overwhelmed) parents who can benefit from a handy reference guide to help them address common behaviors at home and in the community. A must-have for every home with a child with autism and/or sensory issues!
Autism: What Does It Mean to Me?
Autism: What Does It Mean to Me? is an indispensable and transformative tool, and lifelong companion for autistic people, their parents and families, and professionals. Written by internationally renowned autism trainer, teacher, and advocate and best-selling author Catherine Faherty, the workbook is engaged by the autistic child or adult to enhance self-understanding and awareness and foster communication with others about needs, preferences, and identity. Most every facet of a person's life is explored, including areas particular to autism, and areas every person engages with. Among these are: ways of thinking, including focused interests perfection versus doing your best the support of schedules sensory experience, including stimming creative expression learning about and interacting with people writing Social Stories understanding speech and expressions in others types of communication, including verbal or nonverbal self-advocacy and miscommunication supportive structures for school and approaching IEPs friendship, play, online acquaintances and safety emotions, including feeling anxious or upset, depression, and outbursts The book concludes with an extended section on happiness, including relaxation, exercise, gratitude, forgiveness, kindness, positive attitude, and making the world a better place. Extensive materials designed especially for older readers, as well as for parents, therapists, and teachers, are included. Understanding what's actually true and supporting acceptance and appreciation form the cornerstones of Catherine's approach and the workbook. This new book is completely updated and revised from the original edition with the «Asperger's» title. It adds more than 150 pages of brand new material and worksheets
No More Victims
The digital world offers a wonderful way to communicate and socialize with others. Yet, it is also rife with the dangers of being victimized emotionally, physically, and financially. Trusting individuals with autism spectrum disorders, who are oftentimes socially isolated, are especially vulnerable to online predators. Finally, we have a resource to help prepare them for the minefields they may encounter on the Internet.
In this much-needed book, Dr. Baker presents three main areas of concern for our kids:
Cyber bullying
Online sexual predators
Internet scams
Through Dr. Baker's invaluable advice, kids will learn what to look out for, whom to avoid, and how to protect themselves when they're communicating online.
The Parent's Guide to the Medical World of Autism
Dr. Aull clearly explains the world of diagnosis, treatments, and the overwhelming world of medications for parents facing a diagnosis for their child of autism. The much needed explanation of what is safe, and what to use when can be found here. Dr. Aull explain concepts about utilizing medication treatment, why medications might give an adverse outcome, and what might be done to improve the patient's results.
"This is the first book I have read where a wise, highly experienced doctor has discussed his use of medications on many different types of individuals on the autism spectrum" –Dr. Temple Grandin
Hope for the Violently Aggressive Child
Dr. Ralph Ankenman presents new diagnoses and treatment options for children who have severe disruptive meltdowns at home or school. Referred to as Immature Adrenaline Systems Overreactivity (IASO), this approach is based on the relationship between aggression and the body's adrenaline systems. Therefore, IASO does not require psychotropic drugs. Instead, IASO reduces or eliminates psychotropic drugs from a child's regimen. IASO stops episodes of violence and aggression in patients with autism, with bipolar disorder, with developmental disabilities and also many with no mental health diagnosis at all. Standard psychotropic drugs often do not fully resolve these behaviors and lead to unnecessary side effects. A companion website of the same name as this book enables caregivers and parents to discuss and share tips about this new approach, called Immature Adrenaline Systems Overreactivity (IASO).