The molecular mechanisms and protein species associated with the mineralization of mature dental enamel are active areas of research. This book focuses on specific areas of research including the structural chemistry, protein biochemistry and genetics of enamel development.
Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound – pathologists, biochemists, toxicologists, cell and molecular biologists.
Now in its Second Edition, this book helps to unravel the process of evidence-based practice, which requires clinicians to evaluate and collate information from the journals they read. Understanding Clinical Papers, Second Edition uses actual papers to illustrate how to understand and evaluate published research, but goes beyond this to provide an explanation of a range of important research-related topics. Understanding Clinical Papers, Second Edition: Covers everything necessary to understand a clinical research paper Examples are illustrated and based uniquely on tables, abstracts and exerts from published clinical research papers Amazingly clear, lively, accessible style The new edition has been markedly improved and extended, containing, for example, new material on measurement scales, systematic reviews, writing a paper, statistics software and critical appraisal “What strikes the reader… straight away is clarity… promises to become a recommended text for undergraduate and postgraduate courses." JOURNAL OF TROPICAL PEDIATRICS “The writing style is amazingly clear and does not require formal course work in biostatistics or epidemiology…We strongly recommend it for beginners and for easy entry into a complex domain and to experts who we think will enjoy it and who will find it useful as they teach, advise and help others.” QUALITY IN HEALTH CARE “What makes this book unique is that each point presented is illustrated with excerpts from actual papers, often three or four per chapter… this is a very effective teaching device." JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION “This book should be an essential addition to the personal libraries of all health care workers who need to use articles in journals. In these days of evidence-based medicine, this should apply to all physicians, nurses and other health professionals.” ONCOLOGY Understanding Clinical Papers, Second Edition is an invaluable resource for everyone involved directly or indirectly in health care – an ultimate guide for those who read clinical literature.
The variety and number of non-medical practitioners identified for prescribing activity is growing rapidly. Across the country, universities have validated prescribing programmes designed for generic health care practice with a distance-learning component. Towards Prescribing Practice offers readers a comprehensive guide to the principles and practice of prescribing. The subject matter relates to the government content standards for study programmes and takes its cue from recent research in prescribing and patient care in practice. This book embraces the perennial core principles of prescribing practice, management and leadership. Content is organised to facilitate progressive learning, with space allocated in each chapter to practice application through discussion and exercises. The early inclusion of a section on patient-centred planning and concordance enables the reader to assimilate new knowledge within an individualised care approach. The final three chapters are written from different clinical perspectives: mental health, palliative care and emergency care, providing assistance to specific areas of prescribing practice.
This book is a concise, accessible problem-based approach to the subject using case scenarios to facilitate students taking their pre-clinical or basic sciences examinations. Using a family of characters in each case scenario, the text reflects the current changes in medical and biomedical science teaching that is increasingly moving towards a more integrated approach through-problem-based learning. The characters, all members of an extended family, appear in several scenarios and the student becomes familiar with their personalities and their disease processes. Each scenario covers the relevant anatomy, physiology, pathology, pharmacology, microbiology, immunology and biochemistry and enables the reader to grasp the key concepts of basic medical sciences in an integrated fashion. Key Features: Takes an integrated approach to the subject to reflect recent changes in medical and biomedical science curriculum Further Study sections to enhance understanding and enable the student to read around the subject Intended learning outcomes included at the beginning of each chapter Trigger Boxes containing key facts and revision questions included throughout to ensure key concepts are fully understood Integrated Medical Sciences: The Essentials is an essential text for first and second year undergraduates taking medical or biomedical sciences (during the pre-clinical phase for medical students.). The book is also an invaluable resource for nursing degree students and allied health students taking courses in dentistry, physiotherapy and pharmacy. In addition, the book is ideal for US and international medical students preparing for the USMLE Step 1 examination.
Following on from the first book entitled ‘Conservative treatment of Male Urinary Incontinence and Erectile Dysfunction’ this book has been expanded to include seven new chapters and existing chapters have been extensively updated. It is written primarily for those specialist continence physiotherapists who are unsure of the treatment for male patients with lower urinary tract symptoms. The classification of male urinary incontinence has been restructured in line with the International Continence Society standardisation of terminology. The subjective and objective physiotherapy assessment is covered chronologically, to enable the clinician to conduct a meaningful investigation and arrive at a logical diagnosis.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
The second edition of this best-selling book has been thoroughly revised and expanded to reflect the significant changes and advances made in systematic reviewing. New features include discussion on the rationale, meta-analyses of prognostic and diagnostic studies and software, and the use of systematic reviews in practice.
Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known to damage animals and plants via acid rain. Examines the chemistry and biology of aluminum compounds focusing on the evidence for and against aluminum's role in Alzheimer's disease.
The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development. With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design. This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy. Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.