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    Pathology of Hepatocellular Carcinoma

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    This book covers the huge advances made in clinical diagnosis enabling earlier detection, while addressing the recent progress made in treatment of hepatocellular carcinoma (HCC) to enable successful therapy. It draws on the expertise of an internationally recognized author famed for his understanding, knowledge and efforts in defining terms and diagnosis in this area. The text reviews the full range of pathological information of HCC based on the study of surgical cases and biopsy materials, along with images, to help compare findings that may be encountered by pathologists. It also makes special reference to developments in early stage HCC detection and premalignant lesions which can increase effective treatment.

    Biostatistical Methods in Epidemiology

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    An introduction to classical biostatistical methods in epidemiology Biostatistical Methods in Epidemiology provides an introduction to a wide range of methods used to analyze epidemiologic data, with a focus on nonregression techniques. The text includes an extensive discussion of measurement issues in epidemiology, especially confounding. Maximum likelihood, Mantel-Haenszel, and weighted least squares methods are presented for the analysis of closed cohort and case-control data. Kaplan-Meier and Poisson methods are described for the analysis of censored survival data. A justification for using odds ratio methods in case-control studies is provided. Standardization of rates is discussed and the construction of ordinary, multiple decrement and cause-deleted life tables is outlined. Sample size formulas are given for a range of epidemiologic study designs. The text ends with a brief overview of logistic and Cox regression. Other highlights include: Many worked examples based on actual data Discussion of exact methods Recommendations for preferred methods Extensive appendices and references Biostatistical Methods in Epidemiology provides an excellent introduction to the subject for students, while also serving as a comprehensive reference for epidemiologists and other health professionals. For more information, visit www.wiley.com/mathematics

    Statistics at Square Two

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    Updated companion volume to the ever popular Statistics at Square One (SS1) Statistics at Square Two, Second Edition, helps you evaluate the many statistical methods in current use. Going beyond the basics of SS1, it covers sophisticated methods and highlights misunderstandings. Easy to read, it includes annotated computer outputs and keeps formulas to a minimum. Worked examples of methods such as multiple and logical regression reinforce the text. Each chapter concludes with exercises to stimulate learning. All those who need to understand statistics in clinical research papers and apply them in their own research will value this compact and coherent guide.

    Metabolism at a Glance

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    Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline. Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance. Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted. The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level: 1. Metabolic Channelling 2. Glucose homeostasis and Reye's Disease 3. Pentose phosphate pathway and the prodcution of NADPH 4. Tryptophan metabolism in health and disease 5. Tyrosine metabolism in health and disease

    Molecular Nutrition and Genomics

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    This fascinating book draws it subject matter from a range of relevant disciplines that extend from molecular nutrition, nutritional sciences, and nutrition dietetics through to genetics, genomics, and anthropology. It presents a vital portrait of the absolutely fundamental role that nutrition has played and continues to play in shaping who and what human beings are, as well as where they evolved from, and where they may be heading as a species. Molecular Nutrition: Nutrition and the Evolution of Humankind: Blends coverage of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory Takes a molecular biological approach to problem solving, and moves nutrition away from its dietetic and anthropological origins to the front lines of genomic research Covers key concepts in molecular biology; the –omics revolution and bioinformatics; recent human evolution; molecular mechanisms of gene-nutrient interactions; the importance of nutrients and genomics in disease; the evolution of micronutrient metabolism, protein structure, and human disease; nutrients and the human lifecycle; contemporary dietary patterns; leading-edge laboratory tools in nutrigenomics and human evolutionary studies Written by an internationally recognised expert in the field, Molecular Nutrition: Nutrition and the Evolution of Humankind is an invaluable text and reference book for a wide range of teachers, students, and researchers.

    Osseointegration and Dental Implants

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    Osseointegration and Dental Implants offers a comprehensive guide to the state of the art of implant dentistry. Based around the proceedings of the Toronto Osseointegration Conference Revisited, it gathers together information on all aspects of implant dentistry and osseointegration, from basic scientific background, such as the biology of osseointegration and the biomechanics of implant surface design, to clinical relevance, such as treatment planning, loading protocols, and patient rehabilitation. This unique book shows implant dentistry as it is today, in all its diverse clinical applications, and provides an expert discussion of what we know, what we think we know, and what we need to find out.

    Orthodontics at a Glance

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    Orthodontics at a Glance is part of the highly popular at a Glance series. It provides a concise and accessible introduction and revision aid. Following the familiar, easy-to-use at a Glance format, each topic is presented as a double-page spread with key facts accompanied by clear diagrams encapsulating essential knowledge. Structured over four sections, Orthodontics at a Glance covers: Craniofacial growth and development Diagnosis and treatment planning The management of malocclusion Treatment techniques Orthodontics at a Glance is the ideal companion for all students of dentistry, junior clinicians and those working towards orthodontic specialization. In addition the text will provide valuable insight for general dental practitioners wanting to update their orthodontic knowledge, orthodontic nurses, therapists and technicians.

    Physical Assessment for Nurses

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    Physical assessment is a means of evaluating health status using a combination of clinical examination and history taking. A complete physical assessment should form the basis of all nursing care. Physical Assessment for Nurses is aimed at all advanced nurse practitioners and nurses preparing to become advanced nurse practitioners. It forms the foundation for extending practice. The text explores best practice in history taking and summarises the key clinical skills needed to develop and improve physical examination skills and to competently assess, diagnose, plan and provide care. Physical Assessment for Nurses is adapted for nurse practitioners from Turner and Blackwood: Lecture Notes on Clinical Skills (Third edition).

    Stage-Wise Adaptive Designs

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    An expert introduction to stage-wise adaptive designs in all areas of statistics Stage-Wise Adaptive Designs presents the theory and methodology of stage-wise adaptive design across various areas of study within the field of statistics, from sampling surveys and time series analysis to generalized linear models and decision theory. Providing the necessary background material along with illustrative S-PLUS functions, this book serves as a valuable introduction to the problems of adaptive designs. The author begins with a cohesive introduction to the subject and goes on to concentrate on generalized linear models, followed by stage-wise sampling procedures in sampling surveys. Adaptive forecasting in the area of time series analysis is presented in detail, and two chapters are devoted to applications in clinical trials. Bandits problems are also given a thorough treatment along with sequential detection of change-points, sequential applications in industrial statistics, and software reliability. S-Plus functions are available to accompany particular computations, and all examples can be worked out using R, which is available on the book's related FTP site. In addition, a detailed appendix outlines the use of these software functions, while an extensive bibliography directs readers to further research on the subject matter. Assuming only a basic background in statistical topics, Stage-Wise Adaptive Designs is an excellent supplement to statistics courses at the upper-undergraduate and graduate levels. It also serves as a valuable reference for researchers and practitioners in the fields of statistics and biostatistics.

    ECG at a Glance

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    Highly Commended in the Cardiology category at the British Medical Association Book Awards 2009 This brand new title in the popular at a Glance seriescombines the science behind ECGs with how to use them to guide diagnosis and treatment. These key skills are fundamental for examination of the cardiovascular system and all medical students and specialist nurses are expected to be proficient at ECG interpretation. The at a Glance approach provides a large number of clear diagrams and example ECGs alongside concise text, putting the ECGs into a clinical context, all in easy-to-absorb double-page sections.