The ability of future industry to create interactive, flexible and always-on connections between design, manufacturing and supply is an ongoing challenge, affecting competitiveness, efficiency and resourcing. The goal of enterprise interoperability (EI) research is therefore to address the effectiveness of solutions that will successfully prepare organizations for the advent and uptake of new technologies. This volume outlines results and practical concepts from recent and ongoing European research studies in EI, and examines the results of research and discussions cultivated at the I-ESA 2018 conference, “Smart services and business impact of enterprise interoperability”. The conference, designed to encourage collaboration between academic inquiry and real-world industry applications, addressed a number of advanced multidisciplinary topics including Industry 4.0, Big Data, the Internet of Things, Cloud computing, ontology, artificial intelligence, virtual reality and enterprise modelling for future “smart” manufacturing. Readers will find this book to be a source of invaluable knowledge for enterprise architects in a range of industries and organizations.